I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
This is achieved through homologous recombination in ES cells of a targeting vector containing the transgene (conditional in most of the cases) and Rosa26 homology arms. Alternative docking sites are Hprt or Col1a1.