I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
The aim is to facilitate access for the French research community to the services from the unique national infrastructure and scientific expertise of the PHENOMIN’s partners, and to deliver novel mouse lines that providing important opportunities to advance knowledge gene function in relation to human development and disease. The calls are opened to French research applicants. The project will be submitted to a double-bind review process by an external scientific committee based on the scientific evaluation of the proposal according to the following criteria:
Request services are done on line through the internet common platform from the PHENOMIN website. Each applicant will be informed of the outcome of the evaluation within the timing that has been defined for each call. For the calls that are non-free of charge, the cost of the project will be given to the selected applicant for placing an official order.
Do you want to be kept informed of the next PHENOMIN calls ? We invite you to subscribe to our newsletter.
We are glad to announce the 14th PHENOMIN call for proposals for innovative mouse and rat model generation and/or phenotyping. PHENOMIN is able to support scientists to create and phenotype new models to study:
Since 2011, PHENOMIN has generated 265 models for the International Mouse Phenotyping Consortium (knock-out mice to decipher the coding genome) and more than 900 models for the French and International scientific community.
Conditions for eligibility: PHENOMIN is committed to reduce the use of animals (3R’s), only nomination of mutant lines that are not available in known repository, are eligible
Scientific evaluation: All the projects will be reviewed by an external panel of experts beyond the technical feasibility and will be ranked and prioritized
For all models that will be selected, please consider that:
Proposal submission: the submission form has been adapted to be short and simple and can be accessed here.
Fields for submission:
Specialized phenotyping in inflammatory condition and functional immune phenotyping screen
The INFRAFRONTIER mouse clinics offer the examination of mouse mutants using a broad and standardised phenotypic check-up covering key research areas such as behaviour, clinical chemistry, immunology, energy metabolism, and lung function amongst others. If phenotypes are uncovered by the primary assays, mouse mutants can be subjected to more detailed analyses in hypothesis driven and disease focussed phenotyping pipelines.
In this specialised phenotyping call we provide access to a comprehensive panel of phenotyping tests, relying on standardized and customized protocol: Induced secondary phenotyping screen under acute or more chronic inflammatory conditions
OPEN again in summer 2020 - still a few access units available
9 new additional CreERT2 mouse lines are generating by PHENOMIN team and will be made available as soon as possible for the scientific community and 4 CreERT2 mouse models have been already generated by the European EUCOMMTOOLS consortium and and will be further characterized.
The French Foundation for rare diseases "Fondation maladies rares" and the French National Infrastructures PHENOMIN and CELPHEDIA launched 1 join call "new experimental animal models of rare diseases" (2019), and 3 successive joint calls "Mouse models and rare diseases" (in 2017, 2015 and 2013, respectively) to give a significant boost to the development of mouse models, in order to i) gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified, ii) Test and validate therapeutic proofs of concept, at the pre-clinical in vivo level. 50 projects for new mouse models and 3 projects for new rat models have been or are being realized from 145 submissions.
2013: Expressions of Interest for generation of transgenic mouse lines bearing a single gene knock-out (with conditional potential) in order to establish and characterize conditional Knock-Out (cKO) models. 45 additional new mouse lines have been generated by PHENOMIN, in order to be available as soon as possible for the scientific community.