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The aim is to facilitate access for the French research community to the services from the unique national infrastructure and scientific expertise of the PHENOMIN’s partners, and to deliver novel mouse lines that providing important opportunities to advance knowledge gene function in relation to human development and disease. The calls are opened to French research applicants. The project will be submitted to a double-bind review process by an external scientific committee based on the scientific evaluation of the proposal according to the following criteria:
Request services are done online through our PHENOMIN website. Each applicant will be informed of the outcome of the evaluation within the timing that has been defined for each call. For the calls that are non-free of charge, the cost of the project will be given to the selected applicant for placing an official order.
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We are excited to inform you about INFRAFRONTIER´s new free-of-charge TA Call: COVID-19 Therapeutics Pipeline. Our goal is to provide extensive user support to the selected projects for assessing novel potential vaccine and treatment candidates for COVID-19. The TA service is covered by the INFRAFRONTIER2020 project (Horizon 2020).
INFRAFRONTIER partners (PHENOMIN-CIPHE and CCP) will execute this call by providing viral particles, COVID-19 mouse models, cohort production, and BSL3 pipeline analysis. Further functional analysis and advanced readouts like organ histopathological analysis, multiplex assay profiling of cytokines and chemokines in lung and mouse serum, etc. can be provided on a collaborative basis outside the TA call scope.
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9 new additional CreERT2 mouse lines are generating by PHENOMIN team and will be made available as soon as possible for the scientific community and 4 CreERT2 mouse models have been already generated by the European EUCOMMTOOLS consortium and and will be further characterized.
The French Foundation for rare diseases "Fondation maladies rares" and the French National Infrastructures PHENOMIN and CELPHEDIA launched 1 join call "new experimental animal models of rare diseases" (2019), and 3 successive joint calls "Mouse models and rare diseases" (in 2017, 2015 and 2013, respectively) to give a significant boost to the development of mouse models, in order to i) gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified, ii) Test and validate therapeutic proofs of concept, at the pre-clinical in vivo level. 50 projects for new mouse models and 3 projects for new rat models have been or are being realized from 145 submissions.
2013: Expressions of Interest for generation of transgenic mouse lines bearing a single gene knock-out (with conditional potential) in order to establish and characterize conditional Knock-Out (cKO) models. 45 additional new mouse lines have been generated by PHENOMIN, in order to be available as soon as possible for the scientific community.