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The aim is to facilitate access for the French research community to the services from the unique national infrastructure and scientific expertise of the PHENOMIN’s partners, and to deliver novel mouse lines that providing important opportunities to advance knowledge gene function in relation to human development and disease. The calls are opened to French research applicants. The project will be submitted to a double-bind review process by an external scientific committee based on the scientific evaluation of the proposal according to the following criteria:
Request services are done online through our PHENOMIN website. Each applicant will be informed of the outcome of the evaluation within the timing that has been defined for each call. For the calls that are non-free of charge, the cost of the project will be given to the selected applicant for placing an official order.
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We are glad to announce the 16th PHENOMIN call for proposals for innovative mouse and rat model generation. PHENOMIN supports scientists to create new models:
Conditions for eligibility: PHENOMIN is committed to reduce the use of animals (3R’s), only nomination of mutant lines that are not available in known repository, are eligible.
Application deadline: January 31st
Scientific evaluation: All the projects will be reviewed by an external panel of experts beyond the technical feasibility and will be ranked and prioritized. A short description of the project and scientific goal (1 page) will be required for the submission.
For all models that will be selected, please consider that:
Since 2011, PHENOMIN has generated close to 300 models for the International Mouse Phenotyping Consortium (knock-out and point mutation mice to decipher the coding genome) and more than 1400 models for the French and International scientific community.
9 new additional CreERT2 mouse lines are generating by PHENOMIN team and will be made available as soon as possible for the scientific community and 4 CreERT2 mouse models have been already generated by the European EUCOMMTOOLS consortium and and will be further characterized.
The French Foundation for rare diseases "Fondation maladies rares" and the French National Infrastructures PHENOMIN and CELPHEDIA launched 1 join call "new experimental animal models of rare diseases" (2019), and 3 successive joint calls "Mouse models and rare diseases" (in 2017, 2015 and 2013, respectively) to give a significant boost to the development of mouse models, in order to i) gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified, ii) Test and validate therapeutic proofs of concept, at the pre-clinical in vivo level. 50 projects for new mouse models and 3 projects for new rat models have been or are being realized from 145 submissions.
2013: Expressions of Interest for generation of transgenic mouse lines bearing a single gene knock-out (with conditional potential) in order to establish and characterize conditional Knock-Out (cKO) models. 45 additional new mouse lines have been generated by PHENOMIN, in order to be available as soon as possible for the scientific community.