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The aim is to facilitate access for the French research community to the services from the unique national infrastructure and scientific expertise of the PHENOMIN’s partners, and to deliver novel mouse lines that providing important opportunities to advance knowledge gene function in relation to human development and disease. The calls are opened to French research applicants. The project will be submitted to a review process by an external scientific committee based on the scientific evaluation of their project according to the following criteria:
Request services are done on line through the internet common platform from the PHENOMIN website. Each applicant will be informed of the outcome of the evaluation within the timing that has been defined for each call. For the calls that are non-free of charge, the cost of the project will be given to the selected applicant for placing an official order.
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Specialized phenotyping in inflammatory condition and functional immune phenotyping screen
The INFRAFRONTIER mouse clinics offer the examination of mouse mutants using a broad and standardised phenotypic check-up covering key research areas such as behaviour, clinical chemistry, immunology, energy metabolism, and lung function amongst others. If phenotypes are uncovered by the primary assays, mouse mutants can be subjected to more detailed analyses in hypothesis driven and disease focussed phenotyping pipelines.
In this specialised phenotyping call we provide access to a comprehensive panel of phenotyping tests, relying on standardized and customized protocols in key therapeutic areas.
2-Functional immune-phenotyping screen by mass cytometry is proposed by PHENOMIN-CIPHE, and is dedicated to secondary functional immune-phenotyping screen by mass cytometry toassess the effector functions of immune cells:
Please find the application form : Download
9 new additional CreERT2 mouse lines are generating by PHENOMIN team and will be made available as soon as possible for the scientific community and 4 CreERT2 mouse models have been already generated by the European EUCOMMTOOLS consortium and and will be further characterized.
The French Foundation for rare diseases "Fondation maladies rares" and the French National Infrastructure PHENOMIN launched 3 successive joint calls "Mouse models and rare diseases" (in 2017, 2015 and 2013, respectively) to give a significant boost to the development of mouse models, in order to i) gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified, ii) Test and validate therapeutic proofs of concept, at the pre-clinical in vivo level. 45 projects and then new mouse models have been or are being realized from 129 submissions.
2013: Expressions of Interest for generation of transgenic mouse lines bearing a single gene knock-out (with conditional potential) in order to establish and characterize conditional Knock-Out (cKO) models. 45 additional new mouse lines have been generated by PHENOMIN, in order to be available as soon as possible for the scientific community.