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PHENOMIN is the National Infrastructure in Biology and Health granted in 2011 by the Investissements d'Avenir program.
The Infrastructure gathers 3 complementary centers to serve and support the scientific community for the best use of mouse phenogenomics in Research. PHENOMIN missions and realizations enable to
2017 in numbers:
PHENOMIN 2017 activity report (455.2 KB)
in summer 2019, The PHENOMIN infrastructure defended its activity report for the period 2011-2018 and its proposal for 2020-2024. The evaluation of PHENOMIN was sent to us in August 2019 with the following general comment:
“The face-to-face meeting with representatives of the PHENOMIN supported the excellent report/application and the panel can state that PHENOMIN is mature, excellent research infrastructure of great importance to research community of France and with global impact. PHENOMIN has already provided. Representatives of the RI explained also the PHENOMIN’s further development within the CELPHEDIA, where the PHENOMIN should take a lead as a central element, increasing its impact scientific community working with animal models, also other than rodents, thus disseminating their knowledge and expertise over the broad French and international research community.”
The Directors of the PHENOMIN Centers, as well as all the managers of work programs, would like to thank and congratulate all their colleagues for this evaluation which will commit us to a new period of activity of 5 years to serve the scientific community. We will all face new challenges and as Centre Directors we are confident that we can meet them together to provide better services and new tools to the scientific community.
Thus, the objective of PHENOMIN is to develop and maintain according to the community’s needs, innovative, standardized and parallel methodologies, functional analysis and comparative genetics for rodent models. PHENOMIN will allow research teams to carry out integrated comparative functional analysis and to ensure a better translation of results to human. PHENOMIN aims for the new 5 years period:
The Center for ImmunoPHEnomics (CIPHE, Inserm US12 and CNRS/Aix-Marseille Université UMS3367) is a state-of-the-art facility dedicated to create innovative customized mouse models delivered under a specified and opportunistic pathogen free status (SOPF) and to analyze in a comprehensive and standardized manner the immune system of the mouse under normal and infectious conditions.
CIPHE, with its cutting-edge expertise in mouse genetics and immunology also pursues the development of knock-in and knock-out mouse models permitting to understand the nature of the "molecular machines" that determine the function of the cells that constitute the immune system. CIPHE comprises
Using multiparametric flow and mass cytometry as well as advanced microscopy approaches, CIPHE has the unique ability to decipher at the systemic level the complexity of the immune system based on the evaluation of up to 300 quantitative parameters.
The Institut Clinique de la Souris (Mouse Clinical Institute) is a large-scale facility open to the community that ensures
The ICS has also established several resources of genetic tools such as CRE-ERT2 lines, nuclear receptor conditional mutants and a list of GEM lines generated through different european consortia. All these models are available on this page.
The Center for Typing and Archiving of Animal Models is a CNRS laboratory providing the scientific community with fundamental biomedical and pharmaceutical research. It is composed of 2 departments: the CDTA and the CIPA.
Spring 2020 : Renewal of the ISO 9001 : 2015 certification of the Quality Management System of the PHENOMIN infrastructure governance.
PHENOMIN quality policy (410.3 KB)
.PHENOMIN certification 2017 (94.5 KB)