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To facilitate the use of the new mutant resource developed in the mouse, we have generated Cre and FlpO deleter mice on a pure inbred C57BL/6N background (Birling et al., 2012).
The new transgenic constructs were designed to drive either the Cre or the FlpO recombinases, fused to a specific fluorescent marker (respectively the eGFP or the eYFP) and were inserted in the neutral Rosa26 locus.
They allow a rapid, cost-effective and efficient identification of the carrier individuals through the co-expression of the fluorescent marker. The main advantages of these deleters are: