Latest News

SPECIAL EVENT Meet us at the BioFIT- 2017 !
Nov. 23, 2017

Meet us at the BioFIT- 2017 !

Are you ready for innovations ? If so, PHENOMIN-ICS welcomes you for meeting and discussion at the BioFIT- 2017, leading partnering event in Europe for technology transfer, academia-industry collaborations and early-stage innovations in the field of Life Sciences. 

Join and meet us at the booth E2/D8-5 ! 

CALL Precision mammalian model development
Nov. 22, 2017

Precision mammalian model development

INFRAFRONTIER2020 Project - Trans-national Access call - November 2017
Precision mammalian model development

Context and aim of the call
INFRAFRONTIER is the European Research Infrastructure for phenotyping, archiving and distribution of model mammalian genomes. It provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model. It facilitates access for the wider biomedical research community to deliver novel mouse lines that will advance knowledge of human disease and will be of widespread use in biomedical science. 

During the course of the INFRAFRONTIER2020 project a total of 3 Trans-national Access calls for the development of mammalian model development supporting a total of 28 projects will be published. Further calls supporting 10 mouse model and 6 rat model development projects will be released in 2018.

More information and call application form:

Proposal submission to by 20 December 2017.
Proposal evaluation from 21 December 2017 to 15 February 2018.

The INFRAFRONTIER2020 project has received funding from the EU Research and Innovation programme Horizon 2020 (H2020-EU. Developing new world class research infrastructures)

SERVICES PHENOMIN's expertise for your oncology studies
Nov. 16, 2017

PHENOMIN's expertise for your oncology studies

PHENOMIN has developed expertise for oncology studies using mouse models for cancer progression and/or initiation. We are available to discuss projects, in close collaboration with users in order to customize any study to the scientific objectives applying the best adhesion to 3R rules. Our services:

  • Progression and initiation models 
  • Bioluminescent tumor cells
  • Phenotyping and immunophenotyping

Have a look to our whole offer !

WEBINAR Using Cre-lox Recombination to Discover Gene Functions
Nov. 9, 2017

Using Cre-lox Recombination to Discover Gene Functions

PHENOMIN-ICS will present a webinar "The Cre-Toolbox: Revealing Gene Functions with Cre-lox Recombination", November 14, 2017, 9:00 AM EST (3:00 PM CET)

this webinar will discuss

  • Using Cre-lox to understand pleiotropy and dissecting gene functions
  • Overcoming embryonic and early postnatal lethality
  • Inducible inactivation with the creERT2 system
  • Phenotypes induced by Cre driver, tamoxifen toxicity, Cre leakiness: What are the unexpected complexities and technical limitations?
  • CRISPR/Cas9 genome editing for in vivo spatial and/or temporal gene inactivation


  • Guillaume Pavlovic, PhD, Head of the Genetic Engineering and Model Validation Department, PHENOMIN-ICS

Register at:

CreERT2 repository for the collection and distribution of relevant mutant mouse strains:   

Upcoming events

SYMPOSIUM ComTech 2018
January 25, 2018
Lyon, France

French symposium

Le seizième Symposium de la ComTech qui se déroulera le jeudi 25 janvier 2018 sur le site de la Cité Internationale Universitaire de Paris.

"Dans le contexte actuel de nos métiers, nous nous interrogeons souvent sur l’évolution vertigineuse du développement des biotechnologies. De ce fait, il nous a semblé que le moment était venu de faire un point sur les capacités techniques dont nous disposons désormais pour modifier les génomes de nos animaux et d’évaluer quels sont leurs intérêts et leurs limites.

Nous tenterons ainsi de lever certains de nos doutes, d’apaiser nos craintes et d’enrichir nos espoirs.

Cette journée sera également l’occasion d’inaugurer la nouvelle présentation de cette manifestation qui, outre un ensemble de conférences sur le thème choisi, réservera un temps fort d’échange entre tous les participants.

Nous espérons vous retrouver nombreux autour de ce thème – l’action de l’Homme sur l’ADN –, tant sur le plan scientifique que sur celui de l’éthique.

Bien amicalement,
Michèle Pauchard"

A. Diet, PHENOMIN-TAAM, détaillera les activités et services de l'infrasctructure sous forme de présentation affichée, et A. Ayadi, PHENOMIN-ICS presentera oralement les aspects impactant de la mutagenèse sur l'élevage de lignée murine (criblage, obtention et entretien).

N'hésitez pas à les retrouver pendant les sessions dédiées. 

More information at

CONGRESS Toulouse Onco Week 2018
February 3 - 7, 2018
Toulouse, France

The event taking place in the frame of the World Cancer Day aimed at gathering leading international scientists and major private and public players,actors of research and care .This widely publicized, event featured promising scientific breakthroughs and the strong involvement of the medico-scientific community. The fight must go on. Find out about the 2018 programme and join us. Toulouse Onco Week 2018.

PHENOMIN is part of ! 

  • PHENOMIN has developed expertise for oncology studies using mouse models for cancer progression and/or initiation
  • T. Sorg, PHENOMIN-ICS, will present "Generation of the Cancer Pathway Prototype - a platform for predictive cancer pathway modeling" during poster session.
  • G. Bou About, PHENOMIN-ICS, will present the last advanced on animal model for study of hepatocarcinogenesis and preclinical evaluation of therapeutic approaches "Preclinical evaluation of polyethylenimine-mediated RNA interference of Polo-Like Kinase 1 gene for ultrasound image-guided treatment of hepatocellular carcinoma".

Do not hesitate to meet us ! 

More information at

TRAINING COURSE In vivo CRISPR-Cas9 genome editing
March 14 - 15, 2018
Illkirch, France


PHENOMIN's training aims to provide a general framework to get scientists started using CRISPR/Cas9 for in vivo gene editing in rodents.

The main topics are:

  • Learn more about gene editing and how it works
  • Hear about current advances on many technical aspects
  • Optimize the RNA guide design to the genotyping analysis (bioinformatics workshop).
  • Highlight crucial issue in your own scientific project.

The course in conducted in English.

One other session shceduled in November 2018.

Acces to Detailed program and registration procedure

CNRS formation entreprise

PHENOMIN's contact:

More information at

TRAINING COURSE Primary phenotyping of mouse embryos
March 27 - 29, 2018
Illkirch, France


This training is aimed at providing a theoretical and practical background knowledge destined for researchers and engineers that are willing to acquire primary expertise in mouse development. The topics will cover dissection of post implant embryos, histology, whole mount Lac Z staining and confocal imaging of whole embryos.

Prospectives attendees

Researchers, engineers, scientists. Need to have the basic knowledge in animal biology to understand mouse development physiology and the biological technics for phenotyping. 



  • Phenotyping of mouse embryos 
  • Determining the window of lethality of mutant mice in utero
  • Introduction to Mouse embryonic development
  • Classical histology (Fixation, embedding, orientation, sectioning and staining),
  • Immunohistochemistry and in situ hybridization
  • Imaging technics (HREM, micro CT, OPT)
  • High frequency echography to visualize and quantify embryonic development
  • The in-vitro culture of mouse embryos/ drug testing
  • Confocal macroscopy: application in embryology


  • Collection and fixation of mouse embryos and placentas at E10.5 (mid gestation stage)
  • Whole mount Lac Z staining of E10.5 embryos (Step1)
  • Observation of embryos by echography
  • Observation of embryos by micro CT, OPT (potentialy)
  • Whole mount Lac Z staining of E10.5 embryos (step 2) + observation
  • Collection of mouse embryos at E8.5 (early embryonic stage)
  • Collection of mouse fetuses and placentas at E18.5 (just before birth)
  • Observation of embryos at the confocal macroscope
  • Visualization of histological sections at different stages of development. Example of abnormalities.

More information at

WORKSHOP 44ième colloque AFSTAL 2018
June 13 - 15, 2018
Reims, France

Attend the French congress in animal laboratory sciences

Cette année, l'association a décidé de traiter le thème des “limites de l’expérimentation animale au sens large”.

"Au nom de l’AFSTAL, j’ai donc le plaisir de vous convier au 44e Colloque de notre Association, qui se tiendra du 13 au 15 juin 2018 dans la ville de Reims et dont le titre sera “Recherche, Modèle animal, Société”.

Dans la lignée des éditions précédentes, nous consacrerons la première session du colloque à la présentation des plateformes locales et des équipes scientifiques de la région. Nous consacrerons ensuite l’ensemble des conférences aux “limites” dans tous leurs états en portant un regard particulier sur l’intérêt du modèle animal, ses limites, sa dimension éthique en recherche, son rapport et sa perception par la société ainsi que sa réhabilitation. L’aspect scientifique, expérimental et fonctionnel du modèle animal sera ainsi abordé.

Nous apporterons encore cette année une attention toute particulière aux retours d’expérience. C’est pourquoi nous retrouverons au sein du programme de ce colloque, des communications libres et des ateliers de fournisseurs.

La plus grande exposition commerciale d’Europe sera accessible durant la totalité du colloque afin de favoriser les discussions et les échanges entre les congressistes et les exposants. En effet, tous les partenaires, fournisseurs, distributeurs de matériels et de services, incontournables dans le domaine des sciences de l’animal de laboratoire, seront au rendez-vous. À cette occasion, tout en participant au programme scientifique, vous pourrez découvrir les dernières nouveautés et développer votre réseau professionnel et personnel.

L’AFSTAL vous attend donc tous nombreux pour son 44e Colloque qui, comme chaque année, sera organisé de sorte à rendre ce moment aussi convivial que studieux.

Pour le Comité d’Organisation
Frédéric Jacquot, Président de l’AFSTAL"

More information at

TRAINING COURSE Small animal imaging: evolution, potential, limits
November 12 - 16, 2018
Orleans, France


  • Understand potential and limits of different imaging modalities for small animal: biophotonic imaging (bioluminescence, fluorescence 2D and 3D), X rays (X scanner), echography coupled to photoacoustic imaging
  • Be able to select the most suitable approach to address a biological question (phenotyping, functional exploration, biopharmaceutical research...)

The course is conducted in French

Acces to detailed program and registration procedure

CNRS formation entreprises

PHENOMIN's contact: 


More information at