Latest News

ANNOUNCE First governance certified ISO 9001: 2015
July 17, 2017

First governance certified ISO 9001: 2015

The National PHENOMIN Biology and Health Infrastructure: first governance certified ISO 9001: 2015

The National PHENOMIN Biology and Health Infrastructure is managed by a committee composed of three directors of the centre whose missions are set out in the consortium agreement (December 2014).

The management of the National Phenomin Biology and Health Infrastructure must:

  • regularly evaluate national and international needs in the fields of mouse model phenogenomics, regarding the supply of services, scientific and technological innovation and knowledge transfer;
  • formulate and propose to its supervisory bodies a national scientific and financial strategy that meets the expectations of the scientific, academic and private  communities;
  • coordinate and drive the infrastructure to optimise its visibility and clarity of purpose;
  • regularly report to political and financial decision-making bodies (COMINS, ANR, CGI, etc.).

To achieve these goals, the steering committee applied a quality approach and obtained ISO 9001:2015 certification in June 2017.

This certification by a third party validates the organisational quality of PHENOMIN’s governance, enabling it to fulfil its missions and reach the objectives set by its supervisory bodies.


CALL RESULTS Call "Mouse models and rare diseases"
July 11, 2017

Call "Mouse models and rare diseases"

The "Fondation Maladies Rares" in partnership with the National Infrastructure PHENOMIN, is supporting 12 research projects focusing on the development and the study of mouse models in the field of rare diseases.

The Joint Call "Mouse models and rare diseases" aims to give a significant impetus to the creation and the study of mouse models for rare diseases in order to elucidate underlying pathophysiological mechanisms and to develop new therapeutic approaches. This joint call is dedicated to the creation and the characterization of mouse models for rare diseases - constitutive Knock-Out (KO) / conditional Knock-Out (cKO), Knock-In (KI) and transgenic mice.


ANNOUNCE REPLAY- Webinars CRISPR/Cas9 in rodents
June 29, 2017

REPLAY- Webinars CRISPR/Cas9 in rodents

PHENOMIN-ICS presented 2 webinars on CRISPR/Cas 9 in rodents that were hosted by our partner Charles River.

We are pleased to remind they are now avaibale as replay !

-CRISPR/Cas9 in Rodents Animals: The good, The bad and the ugly: March 30th  -  CRISPR/Cas9 has revolutionized the creation of complex mouse and rat models. Genome editing opportunities can seem infinite, but there are parameters that must be considered. 

-Modelling Human Disease in Rodents with CRISPR/Cas9 Genome Editing : June 27th - Why do the results discovered using genetically engineered mice sometimes fail to translate to humans? This webinar will discuss the promise CRISPR/Cas9 has for rodent studies along with strategies for developing better models to understand and treat human disease.

PAPERS IMPC important publications
June 27, 2017

IMPC important publications

Awareness about 2 important publications from IMPC consortium 

1-The analysis of IMPC database that uncovers 360 new human disease models has just been published : Meehan et al., (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nature Genetics.
2-One other publication uncovers the role of sex in biological studies: Natasha Karp et al. (2017) Prevalence of sexual dimorphism in mammalian phenotypic traits. Nature Communications.

Have a look here for more details

Upcoming events

TRAINING COURSE Advances in cytometry: Inserm Workshop 247
September 25 - 27, 2017

Application closed!

Objectives:Flow, mass, spectral cytometry and analysis tools for mutliparametric data analysis in 2 training sessions- 

Ateliers INSERM

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October 16 - 17, 2017
Illkirch, France

The aim of this training course is to provide attendees with the principles and applications of droplet digital PCR (ddPCR). The program will describe ddPCR best practices so that each participant will be able to plan, perform and use the technology whatever the scientific and / or biomedical applications of his project. The speakers will highlight the benefits, but also limitations of the technology, and will illustrate them though applications in functional genomics in rodents.


  • To prepare and design your experiments using ddPCR
  • To understand the advantages and limitations of ddPCR
  • To use ddPCR technology to detect CNVs (copy number variation)


Researchers and experienced technicians.


A good knowledge in molecular biology is required including the use of PCR methods.

The participation is free while the registration is mandatory. The course is conducted in French.

Limited number of attendees : 6

Contact for registration and more information:

Elodie Bedu (PHENOMIN-ICS) 

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TRAINING COURSE Mycoplasmes detection in cell culture
October 18, 2017
Illkirch, France


  • Realize the importance of tracability and quality control in cell culture
  • Be aware of the problem of mycoplasma contamination
  • Realize the diversity of mycoplasma detection methods and be able to choose techniques adapted to each case
  • Know how to prevent mycoplasma contaminations


Engineers and technicians currently cultivating cell lines or planning to cultivate cell lines.


None, except understand French

The course is conducted in French 

Access to detailed program and registration procedure

CNRS formation entreprises

PHENOMIN's contact:

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MEETING 2nd RNA'14 Therapeutics
October 19 - 20, 2017
Barcelona, Spain

This meeting uses to explore new and in-depth developments currently being addressed in RNA therapies.

G. Pavlovic from PHENOMIN-ICS will present "The efficiency and simplicity of CRISPR/Cas9 technology to make precise changes to the genome of living cells has led to a new revolution in genetics"

  • CRISPR/Cas9 genome editing opens new possibilities for modelling human disease in rodents like easy generation of structural variant models and large humanisation of large locus in mouse
  • Scientists are concerned by CRISPR/Cas9 mediated off-targets but other CRISPR drawbacks are poorly evaluated
  • Especially, careful characterisation of mouse and rat generated by CRISPR/Cas9 show unexpected mutations like concatemers, ssODN random integration or chromosomal rearrangements
  • Finally, we will discuss how rodents can be used to evaluate safety of CRISPR/Cas9 therapeutic approaches especially for unexpected genome modifications

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SYMPOSIUM EMBL conference- From Molecular Mechanisms to Translational Applications
October 24 - 27, 2017
Heidelberg, Germany

Why attend?

The EMBL Conference Mammalian Genetics and Genomics: From Molecular Mechanisms to Translational Applications is jointly organised with the International Mammalian Genome Society (IMGS) and the Mouse Molecular Genetics (MMG) meeting. This meeting will provide an international forum for the sharing of cutting-edge research in genetics and genomics that addresses fundamental areas of mammalian biology. The conference will include presentations by established and junior investigators, including trainees, and will include trainee mentoring events, workshops, and networking opportunities within a stimulating and welcoming environment.

M.C. Birling from PHENOMIN-ICS will present new insides in the use of in vivo genome editing by CRISPR/Cas9 "Generation genomic structural variants and chromosomal manipulation by CRISPR/Cas9 genome editing in rodents"


  • Epigenetics and Gene Regulation
  • Comparative Genomics, Computational Methods & Evolution
  • Human disease models
  • Translational & Systems Genetics
  • International Resources
  • Technological Advances
  • Development and Stem Cells
  • Cancer & Immunology

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TRAINING COURSE Small animal imaging: evolution, potential, limits
November 6 - 10, 2017
Orleans, France


  • Understand potential and limits of different imaging modalities for small animal: biophotonic imaging (bioluminescence, fluorescence 2D and 3D), X rays (X scanner), echography coupled to photoaccoustic
  • Be able to select the most suitable approach to address a biological question (phenotyping, functional exploration, biopharmaceutical research...)

The course is conducted in French

Acces to detailed program and registration procedure

CNRS formation entreprises

PHENOMIN's contact: 

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MEETING Annual Meeting of the French Society for Immunology (SFI)
November 7 - 9, 2017
Reims, France

The scientific program will propose a wide range of topics: fundamental immunology, immune therapy, hematology, infectious diseases, vaccinology, autoimmunity, allergology... In particular, this congress will focus on medical immunology. The neutrophil club will organize its 2nd meeting. In addition to society-dependent specific sessions, joint sessions for SFI (Société Française d’Immunologie, French society of Immunology) and AFC (Association Française de Cytometrie, French association in Cytometry) will be organized in order to offer the opportunity to discuss both scientifically and technically.

Since a new area of ​​cytometry requiring the treatment of multidimensional analyzes has already opeend few years ago, the AFC wishes to help you in the control and the choice of reanalysis algorithms. For this, we have just created a Computational Cytometry Club (3C) with the help of three scientists Antonio Cosma, Samuel Grangeaud and Hervé Luche (PHENOMIN-CIPHE). "The goal of this club is to pool individual efforts on data analysis, to structure tests that will be carried out nationally and to select relevant sets of relevant data that will cover different biological issues." We invite you to read the 3C proposal, to reply to the survey and to meet this group at the congress

During the congress, special emphasis will be done on providing young researchers with the opportunity to discuss their work through abstracts that will be selected for posters or for oral presentations. Prizes for the best oral and poster presentations will be awarded at the end of the meeting.

Lydia Campos, President of the AFC

PHENOMIN-CIPHE will attend this meeting. Do not hesitate to met us here !

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CONGRESS 2ieme Congrès National d'Imagerie Du Vivant
November 8 - 9, 2017
Paris, France

Le Congrès National d'Imagerie du Vivant est une occasion unique pour l'ensemble de la communauté française de l'imagerie biomédicale de se rassembler et d'échanger sur les succès et les défis de ce domaine.

Vous êtes invités à prendre part à la seconde édition de cet évènement et à présenter le résultat de vos travaux au cours de sessions transversales aux différentes modalités et thématiques de l'imagerie in vivo.

Le programme déclinera au cours de 8 sessions les succès et les défis en imagerie du vivant :

  • Radiomique / Data mining (cancer et cerveau) / Cohortes
  • L'imagerie interventionnelle dans la médecine de demain
  • L'imagerie dans les nouvelles prises en charge des cancers
  • L'imagerie de l'infection
  • Les avancées technologiques pour le cardio-métabolisme et l'inflammation
  • L'imagerie fonctionnelle cérébrale
  • Session FINYS - les jeunes chercheurs en imagerie
  • Session Industrie - présentations flash des industriels de l'imagerie

Chacune des 6 sessions thématiques comprendra une présentation invitée et des communications sélectionnées

PHENOMIN-TAAM présentera ses derniers résultats quant aux applications precliniques sur les rongeurs ( Real-Time Monitoring of PlacentalOxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging. PLOS ONE | DOI:10.1371/journal.pone.0169850 January 12, 2017)

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MEETING 9 ieme colloque des belles souris
November 9, 2017
Toulouse, France

Le but du Club des Belles Souris est de susciter des échanges scientifiques autour des technologies et techniques en génétique moléculaire de la souris. 

Le programme scientifique du 8 ième Colloque est ouvert !

Vous pouvez vous inscrire dès maintenant en utilisant le site web

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TRAINING COURSE In vivo CRISPR-Cas9 genome editing
November 9 - 10, 2017
Illkirch, France


PHENOMIN's training aims to provide a general framework to get scientists started using CRISPR/Cas9 for in vivo gene editing in rodents.

The main topics are:

  • Learn more about gene editing and how it works
  • Hear about current advances on many technical aspects
  • Optimize the RNA guide design to the genotyping analysis (bioinformatics workshop).
  • Highlight crucial issue in your own scientific project.

The course in conducted in English.

2 Next sessions in 2018- March and November

Acces to Detailed program and registration procedure

CNRS formation entreprise

PHENOMIN's contact:

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November 16 - 18, 2017
Montpellier, France

The CRISPR revolution from bacterial immunity to functional genomics

The French Society for Genetics (SFG) has chosen to devote its Annual Meeting to the fundamental contribution of CRISPR to the broad field of genetics, both for bacterial immunity and as a genome engineering technology.

The meeting starts with an exceptional outreach event, which is open to a wide audience, particularly non-scientists. A conference by Christian Siatka (Ecole de l’ADN, Nimes) will cover societal and ethical aspects that will be then further discussed during open round tables. The scientific program features prestigious speakers, including a keynote address by Emmanuelle Charpentier (Max Planck Institute for Infectious Diseases, Berlin), whose seminal work has been crucial to translating the bacterial CRIPSR system into a genome editing tool.

The meeting is organized into three distinct sessions.

  • Session 1, entitled “Bacterial Immunity and Beyond” and led by Sylvain Moineau (Laval University, Canada), will cover basic research on bacterial immunity, which has to the initial discovery of the CRISPR system and continues to bring novel insights into its diversity and function.
  • Session 2, entitled “Developmental and Physiological Genetics” and led by Norbert Perrimon (Harvard Medical School, Boston), will showcase recent discoveries that have been made using innovative CRISPR-based genetic tools, including controlled epigenetic modifications in Drosophila.
  • Session 3, entitled “From Functional Genomics to Applications” and led by Fabien Nogué (INRA, Versailles), will notably report the perspectives offered by the CRISPR technology for generating new characteristics in species that have agronomic and economic importance.

We are looking forward to seeing many of you in Montpellier next November, for what promises to be an exciting scientific conference!

The organizing committee.

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November 20 - 21, 2017
Paris, France

Rare 2017 is the 5th edition of the meetings organized every two years to promote a health and research policy in France serving people with rare diseases, with a success not denied over the years. PHENOMIN will attend and present data regarding successfull collaborations that allowed generation of mouse lines to study rare diseasesThe meeting is conducted in French.



Rare 2017 est la 5ème édition des rencontres organisées tous les 2 ans pour promouvoir en France une politique de santé et de recherche au service des personnes atteintes de maladies rares, avec un succès non démenti au fil des années.

Fondées par EuroBioMed et portées cette année par la Fondation Maladies Rares, les rencontres Rare réunissent tous les acteurs : décideurs publics, représentants de malades, professionnels de la santé et de la recherche, industriels du médicament, des dispositifs médicaux et des technologies de santé.  Elles sont conçues pour être un laboratoire d’idées et d’analyses pour avancer vers un système de santé plus équitable et performant, plus de connaissances pour la prise de décision en santé, des innovations au service des besoins non satisfaits, et plus de qualité de vie pour les malades et leur famille. Ces axes de réflexion structureront les débats pour identifier où nous en sommes, ce qu’il reste à faire et comment le faire. Chaque axe fera l’objet d’une présentation didactique pour présenter la situation actuelle et les enjeux du futur. Cette intervention sera suivie d’un débat avec les acteurs clés représentant les parties-prenantes et d’un échange avec les participants.

PHENOMIN sera présent et présentera des résultats sur certaines lignées de souris qui ont été générées en collaboration avec ses différents partenariats pour le projet de recherche d'équipe travaillant sur les modèles de maladies rares. 

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November 28 - 29, 2017
Strasbourg, France

BioFIT is the leading partnering event in Europe for technology transfer, academia-industry collaborations and early-stage innovations in the field of Life Sciences. BioFIT is also the marketplace for pre-seed, seed and Series A investment in Life Sciences.

PHENOMIN-ICS will attend this meeting. Join us to meet  !

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TRAINING COURSE Journée Recherche et Santé
December 7, 2017
Paris, France

Espèces modèles en recherche biomédicale: quels atouts, quelles complémentarités ?

Les Journées Recherche et Santé sont des séminaires de formation organisés en collaboration avec les Instituts thématiques multi-organismes à l’initiative du Bureau des formations scientifiques et de soutien à la recherche (BFSSR) du Département des ressources humaines de l’Inserm.

Cette journée est proposée par le Bureau des formations scientifiques et de soutien à la recherche (BFSSR) du Département des ressources humaines de l’'Inserm et l'Institut thématique multi-organismes Aviesan (ITMO) Biologie cellulaire, développement et évolution (BCDE) avec la collaboration de Yann Hérault (CELPHEDIA, PHENOMIN-ICS, Illkirch) et Jean-Stéphane Joly (CELPHEDIA, TEFOR, Institut des Neurosciences Paris-Saclay) qui se tiendra le jeudi 7 décembre 2017 à l'Institut du Cerveau et de Moelle Epinière (ICM), Paris 13e.

Les orateurs présenteront plusieurs modèles animaux avec leurs contraintes et leurs limites et comment ces modèles ont pu ou peuvent encore d'avantage contribuer à des avancées majeures.

Deux tables rondes aborderont la question de la transparence et la reproductibilité des données en recherche ainsi que l'impact sur l'utilisation des animaux modèles, des besoins croissants en médecine personnalisée, en particulier la caractérisation des variations génomiques dont le caractère pathologique ou non reste dans l’ensemble à déterminer.

Inscription gratuite mais obligatoire sur le site dédié jusqu’au 31 octobre.

Conseil scientifique: Yann Hérault (CELPHEDIA, PHENOMIN-ICS, Illkirch) Jean-Stéphane Joly (CELPHEDIA, TEFOR, Institut des Neurosciences Paris-Saclay)

Coordination et organisation  : Thierry Galli, Christine Lemaitre, Sylvie Robine (Institut Thématique Aviesan Biologie cellulaire, développement et évolution) Barro Sow, Christine Tanga (Inserm DRH-BFSSR)



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