Major scientific publications and contributions

2017

A molecular mechanism for the topographic alignment of convergent neural maps.

Savier E, Eglen SJ, Bathélémy A, Perraut M, Pfrieger FW, Lemke G, Reber M.
Elife. 2017 2017 Mar 14;6. pii: e20470.

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Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE

Birling MC, Schaeffer L, André P, Lindner L, Maréchal D, Ayadi A, Sorg T, Pavlovic G, Hérault Y.
Sci Rep 2017 Mar 7;7:43331.

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Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging.

Arthuis CJ, Novell A, Raes F, Escoffre JM, Lerondel S, Le Pape A, Bouakaz A, Perrotin F.
PLoS One 2017 Jan 12;12(1):e0169850.

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RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.

Elhabazi K, Humbert JP, Bertin I, Quillet R, Utard V, Schmitt M, Bourguignon JJ, Laboureyras E, Ben Boujema M, Simonnet G, Ancel C, Simonneaux V, Beltramo M, Bucher B, Sorg T, Meziane H, Schneider E, Petit-Demoulière B, Ilien B, Bihel F, Simonin F.
Neuropharmacology. 2017 Mar 10. pii: S0028-3908(17)30095-3 2017 Mar 10. pii: S0028-3908(17)30095-3

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Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.

Navas VH, Cuche C, Alcover A, Di Bartolo V.
PLoS One. 2017 Jan 20;12(1):e0170396.

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Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome.

Sellier C, Buijsen RA, He F, Natla S, Jung L, Tropel P, Gaucherot A, Jacobs H, Meziane H, Vincent A, Champy MF, Sorg T, Pavlovic G, Wattenhofer-Donze M, Birling MC, Oulad-Abdelghani M, Eberling P, Ruffenach F, Joint M, Anheim M, Martinez-Cerdeno V, Tassone F, Willemsen R, Hukema RK, Viville S, Martinat C, Todd PK, Charlet-Berguerand N.
Neuron. 2017 Jan 18;93(2):331-347.

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2016

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

Delépine C, Meziane H, Nectoux J, Opitz M, Smith AB, Ballatore C, Saillour Y, Bennaceur-Griscelli A, Chang Q, Williams EC, Dahan M, Duboin A, Billuart P, Herault Y, Bienvenu T.
Hum Mol Genet. 2016 Jan 1;25(1):146-57

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A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.

Kassem S, Gaud G, Bernard I, Benamar M, Dejean AS, Liblau R, Fournié GJ, Colacios C, Malissen B, Saoudi A.
PLoS Genet. 2016 Jul 20;12(7):e1006185.

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Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction.

Codner GF, Lindner L, Caulder A, Wattenhofer-Donze M, Radage A, Mertz A, Eisenmann B, Mianne J, Evans EP, Beechey CV, Fray MD, Birling MC, Hérault Y, Pavlovic G, Teboul L.
BMC Cell Biol. 2016 Aug 5;17(1):30.

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A suppressor locus for MODY3-diabetes.

Garcia-Gonzalez MA, Carette C, Bagattin A, Chiral M, Makinistoglu MP, Garbay S, Prévost G, Madaras C, Hérault Y, Leibovici M, Pontoglio M.
Sci Rep. 2016 Sep 26;6:33087.

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Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery.

Ardouin L, Luche H, Chelbi R, Carpentier S, Shawket A, Montanana Sanchis F, Santa Maria C, Grenot P, Alexandre Y, Grégoire C, Fries A, Vu Manh TP, Tamoutounour S, Crozat K, Tomasello E, Jorquera A, Fossum E, Bogen B, Azukizawa H, Bajenoff M, Henri S, Dalod M, Malissen B.
Immunity. 2016 Aug 16;45(2):305-18.

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Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.

Voisinne G, García-Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, Malissen M, Burlet-Schiltz O, Gonzalez de Peredo A, Malissen B, Roncagalli R.
Mol Syst Biol. 2016 Jul 29;12(7):876.

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Corrigendum: Domains of genome-wide gene expression dysregulation in Down's syndrome.

Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, Falconnet E, Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E, Borel C, Deutsch S, et al.
Nature. 2016 Mar 17;531(7594):400.

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Counterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects.

Li J, Leyva-Castillo JM, Hener P, Eisenmann A, Zaafouri S, Jonca N, Serre G, Birling MC, Li M.
J Allergy Clin Immunol. 2016 Jul;138(1):150-161

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Cytomegalovirus Infection of the Rat Developing Brain In Utero Prominently Targets Immune Cells and Promotes Early Microglial Activation.

Cloarec R, Bauer S, Luche H, Buhler E, Pallesi-Pocachard E, Salmi M, Courtens S, Massacrier A, Grenot P, Teissier N, Watrin F, Schaller F, Adle-Biassette H, Gressens P, Malissen M, Stamminger T, Streblow DN, Bruneau N, Szepetowski P.
PLoS One. 2016 Jul 29;11(7):e0160176

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome.

Duchon A, Herault Y.
Front Behav Neurosci. 2016 Jun 3;10:104.

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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L.
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9.

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Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V.
Cell Death Dis. 2016 Nov 10;7(11):e2461.

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Exploiting The CRISPR/CAS9 System to Study Alternative Splicing In Vivo: Application to Titin.

Charton K, Suel L, Henriques SF, Moussu JP, Bovolenta M, Taillepierre M, Becker C, Lipson K, Richard I.
Hum Mol Genet. 2016 Aug 23.

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Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.

Meziane H, Khelfaoui M, Morello N, Hiba B, Calcagno E, Reibel-Foisset S, Selloum M, Chelly J, Humeau Y, Riet F, Zanni G, Herault Y, Bienvenu T, Giustetto M, Billuart P.
Hum Mol Genet. 2016 Jun 1;25(11):2314-2323.

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Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors.

Haziza S, Mohan N, Loe-Mie Y, Lepagnol-Bestel AM, Massou S, Adam MP, Le XL, Viard J, Plancon C, Daudin R, Koebel P, Dorard E, Rose C, Hsieh FJ, Wu CC, Potier B, Herault Y, Sala C, Corvin A, Allinquant B, Chang HC, Treussart F, et al.
Nat Nanotechnol. 2016 Nov 28.

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High Resolution Ultrasound and Photoacoustic Imaging of Orthotopic Lung Cancer in Mice: New Perspectives for Onco-Pharmacology.

Raes F, Sobilo J, Le Mée M, Rétif S, Natkunarajah S, Lerondel S, Le Pape A.
PLoS One. 2016 11(4)

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High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, et al.
Nature. 2016 Sep 14;537(7621):508-514

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How Does Circadian Rhythm Impact Salt Sensitivity of Blood Pressure in Mice? A Study in Two Close C57Bl/6 Substrains.

Combe R, Mudgett J, El Fertak L, Champy MF, Ayme-Dietrich E, Petit-Demoulière B, Sorg T, Herault Y, Madwed JB, Monassier L.
PLoS One. 2016 Apr 18;11(4):e0153472.

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Lymphopoiesis in transgenic mice over-expressing Artemis.

Rivera-Munoz P, Abramowski V, Jacquot S, André P, Charrier S, Lipson-Ruffert K, Fischer A, Galy A, Cavazzana M, de Villartay JP.
Gene Ther. 2016 Feb;23(2):176-86.

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Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice.

Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau,Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux and Eric Robineta
Sci Rep. 2016 6: 35230.

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Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.

McDonald T, Liang HA, Sanoja R, Gotter AL, Kuduk SD, Coleman PJ, Smith KM, Winrow CJ, Renger JJ.
J Neurogenet. 2016 Mar;30(1):32-41

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Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice.

Ricard C, Tchoghandjian A, Luche H, Grenot P, Figarella-Branger D, Rougon G, Malissen M, Debarbieux F.
Sci Rep. 2016 May 19;6:26381.

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Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

Yang X, Mudgett J, Bou-About G, Champy MF, Jacobs H, Monassier L, Pavlovic G, Sorg T, Herault Y, Petit-Demouliere B, Lu K, Feng W, Wang H, Ma LJ, Askew R, Erion MD, Kelley DE, Myers RW, Li C, Guan HP.
J Biol Chem. 2016 Nov 4;291(45):23428-23439.

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Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.

Arbogast T, Ouagazzal AM, Chevalier C, Kopanitsa M, Afinowi N, Migliavacca E, Cowling BS, Birling MC, Champy MF, Reymond A, Herault Y.
PLoS Genet. 2016 Feb 12;12(2):e1005709

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Rev-erba in the brain is essential for circadian food entrainment.

Delezie J, Dumont S, Sandu C, Reibel S, Pevet P, Challet E.
Sci Rep. 2016 Jul 6;6:29386

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Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.

Lakisic G, Lebreton A, Pourpre R, Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, Wattenhofer-Donzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P, Bierne H.
PLoS Genet. 2016 2016 Mar 3;12(3):e1005898

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The cell proliferation antigen Ki-67 organises heterochromatin.

Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, Eguren M, Birling MC, Urbach S, Hem S, Déjardin J, Malumbres M, Jay P, Dulic V, Lafontaine DLj, Feil R, Fisher D.
Elife 2016 Mar 7;5:e13722.

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The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Hérault Y, Guillou F, Bourc'his D.
Science. 2016 Nov 18;354(6314):909-912.

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Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives.

Desoubeaux G, Reichert JM, Sleeman M, Reckamp KL, Ryffel B, Adamczewski JP, Sweeney TD, Vanbever R, Diot P, Owen CA, Page C, Lerondel S, Le Pape A, Heuze-Vourc'h N.
MAbs. 2016 Aug-Sep

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The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.

Roncagalli R, Cucchetti M, Jarmuzynski N, Grégoire C, Bergot E, Audebert S, Baudelet E, Menoita MG, Joachim A, Durand S, Suchanek M, Fiore F, Zhang L, Liang Y, Camoin L, Malissen M, Malissen B.
J Exp Med. 2016 Sep 19.

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Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, et al.
EMBO J. 2016 May 17;35(10):1077-97.

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Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.

Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GH, Chung TJ, Chan DK, Tan KK, Hon TL, Fossum E, Bogen B, et al.
Immunity. 2016 Sep 20;45(3):669-84.

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XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses.

Alexandre YO, Ghilas S, Sanchez C, Le Bon A, Crozat K, Dalod M.
J Exp Med. 2016 Jan 11

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2015

A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.

Erbs E, Faget L, Scherrer G, Matifas A, Filliol D, Vonesch JL, Koch M, Kessler P, Hentsch D, Birling MC, Koutsourakis M, Vasseur L, Veinante P, Kieffer BL, Massotte D.
Brain Struct Funct. 2015 Mar;220(2):677-702.

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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, et al.
Nat Genet. 2015 Sep;47(9):969-78

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An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

Meziane H, Schaller F, Bauer S, Villard C, Matarazzo V, Riet F, Guillon G, Lafitte D, Desarmenien MG, Tauber M, Muscatelli F.
Biol Psychiatry. 2015 Jul 15;78(2):85-94.

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Applying the ARRIVE Guidelines to an In Vivo Database.

Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, Smedley D, Jacobsen J, Mott RF, Iyer V, Matthews P, Melvin DG, Wells S, Flenniken AM, Masuya H, Wakana S, White JK, Lloyd KC, Reynolds CL, Paylor R, West DB, Svenson KL, Chesler EJ, de Angelis MH, Tocchini-Valentini GP, Sorg T, Herault Y, Parkinson H, Mallon AM, Brown SD.
PLoS Biol. 2015 May 20;13(5):e1002151.

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A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

Huet T, Laverny G, Ciesielski F, Molnár F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N.
Cell Rep. 2015 Feb 3;10(4):516-26.

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Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach.

Scavizzi F, Ryder E, Newman S, Raspa M, Gleeson D, Wardle-Jones H, Montoliu L, Fernandez A, Dessain ML, Larrigaldie V, Khorshidi Z, Vuolteenaho R, Soininen R, André P, Jacquot S, Hong Y, de Angelis MH, Ramirez-Solis R, Doe B.
Transgenic Res. 2015 Oct;24(5):921-7

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Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y.
Hum Mol Genet. 2015 Dec 1;24(23):6736-55

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Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats.

Ayme-Dietrich E, Marzak H, Lawson R, Mokni W, Wendling O, Combe R, Becker J, El Fertak L, Champy MF, Matz R, Andriantsitohaina R, Doly S, Boutourlinsky K, Maroteaux L, Monassier L.
J Hypertens. 2015 Nov;33(11):2310-21.

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Deletion of the App-Runx1 region in mice models human partial monosomy 21.

Arbogast T, Raveau M, Chevalier C, Nalesso V, Dembele D, Jacobs H, Wendling O, Roux M, Duchon A, Herault Y.
Dis Model Mech. 2015 Jun;8(6):623-34.

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Dosage of the abcg1-u2af1 region modifies locomotor and cognitive deficits observed in the tc1 mouse model of down syndrome.

Marechal D, Pereira PL, Duchon A, Herault Y.
PLoS One. 2015 Feb 23;10(2)

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Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly.

Ishiuchi T, Enriquez-Gasca R, Mizutani E, Bošković A, Ziegler-Birling C, Rodriguez-Terrones D, Wakayama T, Vaquerizas JM, Torres-Padilla ME.
Nat Struct Mol Biol. 2015 Sep;22(9):662-71

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Evaluating the efficiency of isotope transmission for improved panel design and a comparison of the detection sensitivities of mass cytometer instruments.

Tricot S, Meyrand M, Sammicheli C, Elhmouzi-Younes J, Corneau A, Bertholet S, Malissen M, Le Grand R, Nuti S, Luche H, Cosma A.
Cytometry A. 2015 Apr;87(4):357-68.

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IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.

Besnard AG, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, Couper KN, Ryffel B, Liew FY.
PLoS Pathog. 2015 Feb 6;11(2):e1004607.

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INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community.

Meehan TF, Chen CK, Koscielny G, Relac M, Wilkinson P, Flicek P, Parkinson H, Castro A, Fessele S, Steinkamp R, Hagn M, Raess M, de Angelis MH, Bottomley J, Ramirez-Solis R, Smedley D, Ball S, Blake A, Fray M, Kenyon J, Mallon AM, Brown S, Massimi M, Matteoni R, Tocchini-Valentini G, Herault Y, Kollias G, Fleming A, Ulfhake B, Demengeot J, Fremond C, Bosch F, Montoliu L, Soininen R, Schughart K, Brakebusch C, Sedlacek R, Rülicke T, McKerlie C, Malissen B, Iraqi F, Jonkers J, Russig H, Huylebroeck D.
Nucleic Acids Res. 2015 Jan

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La révolution de la génomique fonctionnelle

Guillaume Pavlovic, Tania Sorg, Abdelkader Ayadi, Marie-Christine Birling, Isabelle Goncalves, Cecile Fremont, Bernard Malissen, Yann Hérault
Biofutur 2015 3 dec 2015;34(371):47-53

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LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.

Hussein MA, Shrestha E, Ouimet M, Barrett TJ, Leone S, Moore KJ, Hérault Y, Fisher EA, Garabedian MJ.
PLoS One. 2015 Aug 19;10(8):e0135218.

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Nociceptin/Orphanin-FQ Modulation of Learning and Memory.

Abdel-Mouttalib O.
Vitam Horm. 2015 97:323-45.

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Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal hspa13-app region.

Brault V, Duchon A, Romestaing C, Sahun I, Pothion S, Karout M, Borel C, Dembele D, Bizot JC, Messaddeq N, Sharp AJ, Roussel D, Antonarakis SE, Dierssen M, Hérault Y.
PLoS Genet. 2015 Mar 24;11(3):e1005062.

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Principles and application of LIMS in mouse clinics

Holger Maier, Christine Schütt, Ralph Steinkamp, Anja Hurt, Elida Schneltzer, Philipp Gormanns, Christoph Lengger, Mark Griffiths, David Melvin, Neha Agrawal, Rafael Alcantara, Arthur Evans, David Gannon, Simon Holroyd, Christian Kipp, Navis Pretheeba Raj, David Richardson, Sophie LeBlanc, Laurent Vasseur, Hiroshi Masuya, Kimio Kobayashi, Tomohiro Suzuki, Nobuhiko Tanaka, Shigeharu Wakana, Alison Walling, David Clary, Juan Gallegos, Helmut Fuchs, Martin Hrabě de Angelis,corresponding author# and Valerie Gailus-Durner
Mamm Genome. 2015 26(9-10): 467–481.

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Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome.

Mukherji A, Kobiita A, Damara M, Misra N, Meziane H, Champy MF, Chambon P.
Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6691-8.

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The thymus-specific serine protease TSSP/PRSS16 is crucial for the antitumoral role of CD4(+) T cells.

Brisson L, Pouyet L, N'guessan P, Garcia S, Lopes N, Warcollier G, Iovanna JL, Carrier A.
Cell Rep. 2015 Jan 6;10(1):39-46.

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2014

Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome.

Sahun I, Marechal D, Pereira PL, Nalesso V, Gruart A, Garcia JM, Antonarakis SE, Dierssen M, Herault Y.
Genetics. 2014 Jul;197(3):899-912

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Conditional ablation of NKp46+ cells using a novel Ncr1(greenCre) mouse strain: NK cells are essential for protection against pulmonary B16 metastases.

Merzoug LB, Marie S, Satoh-Takayama N, Lesjean S, Albanesi M, Luche H, Fehling HJ, Santo JP, Vosshenrich CA.
Eur J Immunol. 2014 Nov

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Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.

Mouton-Liger F, Sahùn I, Collin T, Lopes Pereira P, Masini D, Thomas S, Paly E, Luilier S, Même S, Jouhault Q, Bennaï S, Beloeil JC, Bizot JC, Hérault Y, Dierssen M, Créau N.
Neurobiol Dis. 2014 Mar;63:92-106.

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Domains of genome-wide gene expression dysregulation in Down's syndrome.

Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, Falconnet E, Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E, Borel C, Deutsch S, Feki A, Stamatoyannopoulos JA, Herault Y, van Steensel B, Guigo R, Antonarakis S.
Nature. 2014 Apr 17;508(7496):345-50.

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Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R.
Cell Cycle. 2014 13(14):2221-9.

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Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A.
PLoS One. 2014 Sep 9;9(9):e107048.

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Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.

De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fito M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, Covas MI, Blehaut H, Herault Y, Delabar JM, Dierssen M.
Mol Nutr Food Res. 2014 Feb;58(2):278-88

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Fate of inhaled monoclonal antibodies after the deposition of aerosolized particles in the respiratory system.

Guilleminault L, Azzopardi N, Arnoult C, Sobilo J, Hervé V, Montharu J, Guillon A, Andres C, Herault O, Le Pape A, Diot P, Lemarié E, Paintaud G, Gouilleux-Gruart V, Heuzé-Vourc'h N.
J Control Release. 2014 Dec 28

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Generation and Use of Transgenic Mice in Drug Discovery

Pavlovic, G., Brault, V., Sorg, T. and Hérault, Y.
Methods And Principles In Medicinal Chemistry: In Vivo Models For Drug Discovery 2014 11 aug ; 62(part 6):131-148

View on Pubmed


Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder.

Segura-Puimedon M, Sahùn I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano V.
Hum Mol Genet. 2014 Dec 15;23(24):6481-94.

View on Pubmed


Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

Lopez-Delisle L, Pierre-Eugène C, Bloch-Gallego E, Birling MC, Duband JL, Durand E, Bourgeois T, Matrot B, Sorg T, Huerre M, Meziane H, Roux MJ, Champy MF, Gallego J, Delattre O, Janoueix-Lerosey I.
Oncotarget. 2014 May 15;5(9):2703-13.

View on Pubmed


Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

Karp NA, Speak AO, White JK, Adams DJ, Hrabé de Angelis M, Herault Y, Mott RF.
PLoS One. 2014 Oct 24;9(10):e111239.

View on Pubmed


Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?

Koutseff A, Mittelhaeuser C, Essabri K, Auwerx J, Meziane H.
Brain Res. 2014 Jan 13;1542:32-40.

View on Pubmed


Improved method to retain cytosolic reporter protein fluorescence while staining for nuclear proteins.

Heinen AP, Wanke F, Moos S, Attig S, Luche H, Pal PP, Budisa N, Fehling HJ, Waisman A, Kurschus FC.
Cytometry A. 2014 Jul

View on Pubmed


Integrative biology of T cell activation.

Malissen B, Grégoire C, Malissen M, Roncagalli R.
Nat Immunol. 2014 Sep

View on Pubmed


Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice.

Penhoat A, Fayard L, Stefanutti A, Mithieux G, Rajas F.
Metabolism. 2014 Jan;63(1):104-11.

View on Pubmed


LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.

Tajan M, Batut A, Cadoudal T, Deleruyelle S, Le Gonidec S, Saint Laurent C, Vomscheid M, Wanecq E, Tréguer K, De Rocca Serra-Nédélec A, Vinel C, Marques MA, Pozzo J, Kunduzova O, Salles JP, Tauber M, Raynal P, Cavé H, Edouard T, Valet P, Yart A.
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4494-503.

View on Pubmed


Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.

Dahdah A, Gautier G, Attout T, Fiore F, Lebourdais E, Msallam R, Daëron M, Monteiro RC, Benhamou M, Charles N, Davoust J, Blank U, Malissen B, Launay P.
J Clin Invest. 2014 Oct

View on Pubmed


Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.

De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Bäckhed F, Mithieux G.
Cell. 2014 Jan 16;156(1-2):84-96.

View on Pubmed


Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions.

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F.
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E283-90.

View on Pubmed


NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.

Bechade C, Colasse S, Diana MA, Rouault M, Bessis A.
Glia. 2014 Jun;62(6):956-63.

View on Pubmed


Old spontaneously hypertensive rats gather together typical features of human chronic left-ventricular dysfunction with preserved ejection fraction.

Marzak H, Ayme-Dietrich E, Lawson R, Mokni W, Combe R, Becker J, Fertak LE, Champy MF, Monassier L.
J Hypertens. 2014 Jun;32(6):1307-16

View on Pubmed


Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration.

Griciuc A, Roux MJ, Merl J, Giangrande A, Hauck SM, Aron L, Ueffing M.
J Neurosci. 2014 Feb 19;34(8):2797-812

View on Pubmed


Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lähdesmäki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B.
Nat Immunol. 2014 Apr

View on Pubmed


Regulator of G-protein signaling 18 controls both platelet generation and function.

Delesque-Touchard N, Pendaries C, Volle-Challier C, Millet L, Salel V, Hervé C, Pflieger AM, Berthou-Soulie L, Prades C, Sorg T, Herbert JM, Savi P, Bono F.
PLoS One. 2014 Nov 18;9(11):e113215.

View on Pubmed


Rfx6 maintains the functional identity of adult pancreatic β cells.

Piccand J, Strasser P, Hodson DJ, Meunier A, Ye T, Keime C, Birling MC, Rutter GA, Gradwohl G.
Cell Rep. 2014 Dec 24;9(6):2219-32.

View on Pubmed


Skin progenitor cells contribute to bleomycin-induced skin fibrosis.

Liu S, Herault Y, Pavlovic G, Leask A.
Arthritis Rheumatol. 2014 Mar;66(3):707-13.

View on Pubmed


Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.

Clar J, Gri B, Calderaro J, Birling MC, Hérault Y, Smit GP, Mithieux G, Rajas F.
Kidney Int. 2014 Oct;86(4):747-56

View on Pubmed


The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.

Tort O, Tanco S, Rocha C, Bièche I, Seixas C, Bosc C, Andrieux A, Moutin MJ, Avilés FX, Lorenzo J, Janke C.
Mol Biol Cell. 2014 Oct 1;25(19):3017-27.

View on Pubmed


The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.

Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U.
Brain. 2014 Mar;137(Pt 3):668-82.

View on Pubmed


The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.

Labialle S, Marty V, Bortolin-Cavaille ML, Hoareau-Osman M, Pradère JP, Valet P, Martin PG, Cavaille J.
EMBO J. 2014 Oct 1;33(19):2216-30.

View on Pubmed


2013

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.

Simon MM, Greenaway S, White JK, Fuchs H, Gailus-Durner V, Wells S, Sorg T, Wong K, Bedu E, Cartwright EJ, Dacquin R, Djebali S, Estabel J, Graw J, Ingham NJ, Jackson IJ, Lengeling A, Mandillo S, Marvel J, Meziane H, Preitner F, Puk O, et al.
Genome Biol. 2013 Jul 31;14(7):R82.

View on Pubmed


Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening.

Adams D, Baldock R, Bhattacharya S, Copp AJ, Dickinson M, Greene ND, Henkelman M, Justice M, Mohun T, Murray SA, Pauws E, Raess M, Rossant J, Weaver T, West D.
Dis Model Mech. 2013 May;6(3):571-9.

View on Pubmed


Climbing fiber input shapes reciprocity of Purkinje cell firing.

Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI.
Neuron. 2013 May 22;78(4):700-13.

View on Pubmed


Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.
Mol Cell. 2013 Dec 26;52(6):769-82.

View on Pubmed


Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease.

Nemazanyy I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russell RC, Guan KL, Nishino I, Sandri M, Pende M, Panasyuk G.
EMBO Mol Med. 2013 Jun;5(6):870-90.

View on Pubmed


Distinct fibroblast lineages determine dermal architecture in skin development and repair.

Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM.
Nature. 2013 Dec 12;504(7479):277-81.

View on Pubmed


Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.

Koutsopoulos OS, Kretz C, Weller CM, Roux A, Mojzisova H, Böhm J, Koch C, Toussaint A, Heckel E, Stemkens D, Ter Horst SA, Thibault C, Koch M, Mehdi SQ, Bijlsma EK, Mandel JL, Vermot J, Laporte J.
Eur J Hum Genet. 2013 Jun;21(6):637-42.

View on Pubmed


Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.

Elhabazi K, Humbert JP, Bertin I, Schmitt M, Bihel F, Bourguignon JJ, Bucher B, Becker JA, Sorg T, Meziane H, Petit-Demoulière B, Ilien B, Simonin F.
Neuropharmacology. 2013 Dec;75:164-71.

View on Pubmed


FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents: a report of the Federation of European Laboratory Animal Science Associations Working Group.

Bonaparte D, Cinelli P, Douni E, Herault Y, Maas M, Pakarinen P, Poutanen M, Lafuente MS, Scavizzi F
Lab Anim. 2013 Jul;47(3):134-45.

View on Pubmed


Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs.

Mukherji A, Kobiita A, Ye T, Chambon P.
Cell. 2013 May 9;153(4):812-27.

View on Pubmed


Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

Ben M'Barek K, Pla P, Orvoen S, Benstaali C, Godin JD, Gardier AM, Saudou F, David DJ, Humbert S.
J Neurosci. 2013 May 15;33(20):8608-20.

View on Pubmed


Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.

Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, René F, Drapeau P, Rouleau GA, Dupuis L.
Hum Mol Genet. 2013 Jun 15;22(12):2350-60.

View on Pubmed


JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

Hasan S, Lacout C, Marty C, Cuingnet M, Solary E, Vainchenker W, Villeval JL.
Blood. 2013 Aug 22;122(8):1464-77.

View on Pubmed


Multicolor fate mapping of Langerhans cell homeostasis.

Ghigo C, Mondor I, Jorquera A, Nowak J, Wienert S, Zahner SP, Clausen BE, Luche H, Malissen B, Klauschen F, Bajenoff M.
J Exp Med. 2013 Aug 26

View on Pubmed


Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice.

Sedhom MA, Pichery M, Murdoch JR, Foligné B, Ortega N, Normand S, Mertz K, Sanmugalingam D, Brault L, Grandjean T, Lefrancais E, Fallon PG, Quesniaux V, Peyrin-Biroulet L, Cathomas G, Junt T, Chamaillard M, Girard JP, Ryffel B.
Gut. 2013 Dec;62(12):1714-23.

View on Pubmed


NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P, Chamaillard M.
J Clin Invest. 2013 Feb;123(2):700-11. doi: 10.1172/JCI62236.

View on Pubmed


p53-PGC-1a pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice.

Villeneuve C, Guilbeau-Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, De Paulis D, Couderc B, Spreux-Varoquaux O, Tortosa F, Garnier A, Knauf C, Valet P, Borchi E, Nediani C, Gharib A, Ovize M, Delisle MB, Parini A, Mialet-Perez J.
Antioxid Redox Signal. 2013 Jan 1;18(1):5-18.

View on Pubmed


Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected].

Bounab Y, Hesse AM, Iannascoli B, Grieco L, Couté Y, Niarakis A, Roncagalli R, Lie E, Lam KP, Demangel C, Thieffry D, Garin J, Malissen B, Daëron M.
Mol Cell Proteomics. 2013 Oct

View on Pubmed


Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency.

Gallet M, Saïdi S, Haÿ E, Photsavang J, Marty C, Sailland J, Carnesecchi J, Tribollet V, Barenton B, Forcet C, Birling MC, Sorg T, Chassande O, Cohen-Solal M, Vanacker JM.
PLoS One. 2013 8(1):e54837

View on Pubmed


SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth.

Berger H, Végran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangère V, Chevriaux A, Rébé C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L.
Cancer Res. 2013 Jun 15;73(12):3578-90.

View on Pubmed


Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.

Bhutta MF, Cheeseman MT, Herault Y, Yu YE, Brown SD.
Mamm Genome. 2013 Dec;24(11-12):439-45.

View on Pubmed


The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.

Meziane H, Fraulob V, Riet F, Krezel W, Selloum M, Geffarth M, Acampora D, Hérault Y, Simeone A, Brand M, Dollé P, Rhinn M.
PeerJ. 2013 Aug 29;1:e142.

View on Pubmed


The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.

Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB.
J Biol Chem. 2013 Aug 23;288(34):24528-39.

View on Pubmed


2012

Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice.

Danglot L, Zylbersztejn K, Petkovic M, Gauberti M, Meziane H, Combe R, Champy MF, Birling MC, Pavlovic G, Bizot JC, Trovero F, Della Ragione F, Proux-Gillardeaux V, Sorg T, Vivien D, D'Esposito M, Galli T.
J Neurosci. 2012 Feb 8;32(6):1962-8.

View on Pubmed


Acoustic Startle Reflex and Prepulse Inhibition.

Ouagazzal AM, Meziane H.
Curr Protoc Mouse Biol. 2012 Mar 1;2(1):25-35.

View on Pubmed


Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists.

Ces A, Reiss D, Walter O, Wichmann J, Prinssen EP, Kieffer BL, Ouagazzal AM.
Neuropsychopharmacology. 2012 Jan;37(2):378-89.

View on Pubmed


Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation.

Boskovic A, Bender A, Gall L, Ziegler-Birling C, Beaujean N, Torres-Padilla ME.
Epigenetics. 2012 Jul;7(7):747-57.

View on Pubmed


An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.

Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S.
Nature. 2012 Jul 12;487(7406):249-53.

View on Pubmed


BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response.

Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M, Dupuis L, Loeffler JP, King P, Mutter-Schmidt C, Petrovsky N, Stoetzel C, Dollfus H.
Cell Metab. 2012 Sep 5;16(3):363-77.

View on Pubmed


Control of ground-state pluripotency by allelic regulation of Nanog.

Miyanari Y, Torres-Padilla ME.
Nature. 2012 Feb 12;483(7390):470-3.

View on Pubmed


Defects in gallbladder emptying and bile Acid homeostasis in mice with cystic fibrosis transmembrane conductance regulator deficiencies.

Debray D, Rainteau D, Barbu V, Rouahi M, El Mourabit H, Lerondel S, Rey C, Humbert L, Wendum D, Cottart CH, Dawson P, Chignard N, Housset C.
Gastroenterology 2012 Jun;142(7):1581-91.e6.

View on Pubmed


DYRK1A: a master regulatory protein controlling brain growth.

Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM.
Neurobiol Dis. 2012 Apr;46(1):190-203

View on Pubmed


Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses.

Zhou YD, Zhang D, Ozkaynak E, Wang X, Kasper EM, Leguern E, Baulac S, Anderson MP.
J Neurosci. 2012 Jan 18;32(3):903-10.

View on Pubmed


Estrogen dependent activation function of ERβ is essential for the sexual behavior of mouse females.

Antal MC, Petit-Demoulière B, Meziane H, Chambon P, Krust A.
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19822-7.

View on Pubmed


Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL/6N genetic background.

Birling MC, Dierich A, Jacquot S, Hérault Y, Pavlovic G.
Genesis. 2012 Jun;50(6):482-9.

View on Pubmed


Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.

Elhabazi K, Trigo JM, Mollereau C, Moulédous L, Zajac JM, Bihel F, Schmitt M, Bourguignon JJ, Meziane H, Petit-demoulière B, Bockel F, Maldonado R, Simonin F.
Br J Pharmacol. 2012 Jan;165(2):424-35.

View on Pubmed


LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.

Somandin C, Gerber D, Pereira JA, Horn M, Suter U.
Glia. 2012 Oct;60(10):1518-28.

View on Pubmed


Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H, Fray M, Gailus-Durner V, Greenaway S, Houghton R, Karp N, Leblanc S, Lengger C, Maier H, Mallon AM, Marschall S, Melvin D, Morgan H, Pavlovic G, Ryder E, Skarnes WC, Selloum M, Ramirez-Solis R, et al.
Mamm Genome. 2012 Oct;23(9-10):600-10

View on Pubmed


Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.

Horn M, Baumann R, Pereira JA, Sidiropoulos PN, Somandin C, Welzl H, Stendel C, Lühmann T, Wessig C, Toyka KV, Relvas JB, Senderek J, Suter U.
Brain. 2012 Dec;135(Pt 12):3567-83.

View on Pubmed


Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability.

Mockel A, Obringer C, Hakvoort TB, Seeliger M, Lamers WH, Stoetzel C, Dollfus H, Marion V.
J Biol Chem. 2012 Oct 26;287(44):37483-94.

View on Pubmed


Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

Amoasii L, Bertazzi DL, Tronchère H, Hnia K, Chicanne G, Rinaldi B, Cowling BS, Ferry A, Klaholz B, Payrastre B, Laporte J, Friant S.
PLoS Genet. 2012 8(10):e1002965

View on Pubmed


Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle.

Hnia K, Kretz C, Amoasii L, Böhm J, Liu X, Messaddeq N, Qu CK, Laporte J.
Adv Biol Regul. 2012 Jan;52(1):98-107.

View on Pubmed


Structural and functional concepts in current mouse phenotyping and archiving facilities.

Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K.
J Am Assoc Lab Anim Sci. 2012 Jul;51(4):418-35.

View on Pubmed


Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.

Andreux PA, Williams EG, Koutnikova H, Houtkooper RH, Champy MF, Henry H, Schoonjans K, Williams RW, Auwerx J.
Cell. 2012 Sep 14;150(6):1287-99.

View on Pubmed


The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Raveau M, Lignon JM, Nalesso V, Duchon A, Groner Y, Sharp AJ, Dembele D, Brault V, Hérault Y.
PLoS Genet. 2012 May;8(5):e1002724.

View on Pubmed


The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Raveau M, Lignon JM, Nalesso V, Duchon A, Groner Y, Sharp AJ, Dembele D, Brault V, Hérault Y.
PLoS Genet. 2012 May;8(5):e1002724.

View on Pubmed


The first generation of β-galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy.

Legigan T, Clarhaut J, Tranoy-Opalinski I, Monvoisin A, Renoux B, Thomas M, Le Pape A, Lerondel S, Papot S.
Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11606-10.

View on Pubmed


The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells.

Lamiche C, Clarhaut J, Strale PO, Crespin S, Pedretti N, Bernard FX, Naus CC, Chen VC, Foster LJ, Defamie N, Mesnil M, Debiais F, Cronier L.
Clin Exp Metastasis. 2012 Feb

View on Pubmed


The in vivo Down syndrome genomic library in mouse.

Herault Y, Duchon A, Velot E, Marechal D, Brault V.
Prog Brain Res 2012 197:169-97

View on Pubmed


The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, et al.
Mamm Genome. 2012 Oct;23(9-10):580-6

View on Pubmed


The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.

Glasco DM, Sittaramane V, Bryant W, Fritzsch B, Sawant A, Paudyal A, Stewart M, Andre P, Cadete Vilhais-Neto G, Yang Y, Song MR, Murdoch JN, Chandrasekhar A.
Dev Biol. 2012 Sep 15;369(2):211-22.

View on Pubmed


The nuclear receptor REV-ERBalpha-/- is required for the daily balance of carbohydrate and lipid metabolism.

Delezie J, Dumont S, Dardente H, Oudart H, Gréchez-Cassiau A, Klosen P, Teboul M, Delaunay F, Pévet P, Challet E.
FASEB J. 2012 Aug;26(8):3321-35.

View on Pubmed


2011

A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P, Bierne H.
Science. 2011 Mar 11;331(6022):1319-21.

View on Pubmed


Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.

Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF.
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6.

View on Pubmed


Characterization and Validation of Cre-Driver Mouse Lines

Gofflot F, Wendling O, Chartoire N, Birling MC, Warot X, Auwerx J
Curr Protoc Mouse Biol. 2011 Mar 1;1(1):1-15.

View on Pubmed


Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.

Brault V, Martin B, Costet N, Bizot JC, Herault Y.
PLoS One. 2011 6(11):e27845.

View on Pubmed


Chronic Treatment with a Promnesiant GABA-A 5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model.

Braudeau J, Dauphinot L, Duchon A, Loistron A, Dodd RH, Hérault Y, Delatour B, Potier MC.
Adv Pharmacol Sci 2011 2011():153218

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Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever XC, Weibel R, Matifas A, Reiss D, Filliol D, Nassar MA, Wood JN, Maldonado R, Kieffer BL.
Pain. 2011 Jun;152(6):1238-48.

View on Pubmed


Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.

Deschamps K, Cromlish W, Weicker S, Lamontagne S, Huszar SL, Gauthier JY, Mudgett JS, Guimond A, Romand R, Frossard N, Percival MD, Slipetz D, Tan CM.
Am J Respir Cell Mol Biol. 2011 Jul

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Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.

Duchon A, Raveau M, Chevalier C, Nalesso V, Sharp AJ, Herault Y.
Mamm Genome. 2011 Dec;22(11-12):674-84.

View on Pubmed


Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.

Goeldner C, Lutz PE, Darcq E, Halter T, Clesse D, Ouagazzal AM, Kieffer BL.
Biol Psychiatry. 2011 Feb 1;69(3):236-44.

View on Pubmed


Influence of endogenous opioid systems on T lymphocytes as assessed by the knockout of mu, delta and kappa opioid receptors.

Karaji AG, Reiss D, Matifas A, Kieffer BL, Gavériaux-Ruff C.
J Neuroimmune Pharmacol. 2011 Dec;6(4):608-16.

View on Pubmed


Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment.

Rhinn M, Schuhbaur B, Niederreither K, Dollé P.
Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16687-92.

View on Pubmed


Mouse Breeding and Colony Management.

Ayadi A, Ferrand G, Goncalves da Cruz I, Warot X
Curr Protoc Mouse Biol. 2011 Mar 1;1(1):239-64.

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Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.

Hnia K, Tronchère H, Tomczak KK, Amoasii L, Schultz P, Beggs AH, Payrastre B, Mandel JL, Laporte J.
J Clin Invest. 2011 Jan;121(1):70-85.

View on Pubmed


Necdin protects embryonic motoneurons from programmed cell death.

Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, Raoul C, Muscatelli F.
PLoS One. 2011 2011;6(9):e23764.

View on Pubmed


Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F.
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8.

View on Pubmed


Prmt2 regulates the lipopolysaccharide-induced responses in lungs and macrophages.

Dalloneau E, Pereira PL, Brault V, Nabel EG, Hérault Y.
J Immunol. 2011 Nov 1;187(9):4826-34.

View on Pubmed


Protein-induced satiety is abolished in the absence of intestinal gluconeogenesis.

Penhoat A, Mutel E, Amigo-Correig M, Pillot B, Stefanutti A, Rajas F, Mithieux G.
Physiol Behav. 2011 Nov 30;105(1):89-93

View on Pubmed


PTBP1 is required for embryonic development before gastrulation.

Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, Stewart AF, Solimena M.
PLoS One. 2011 Feb 17

View on Pubmed


Reduced body weight in male Tspan8-deficient mice.

Deschamps K, Cromlish W, Weicker S, Lamontagne S, Huszar SL, Gauthier JY, Mudgett JS, Guimond A, Romand R, Frossard N, Percival MD, Slipetz D, Tan CM.
Am J Respir Cell Mol Biol. 2011 Jul

View on Pubmed


Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C.
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6288-93.

View on Pubmed


Standardized Post-Mortem Examination and Fixation Procedures for Mutant and Treated Mice

Antal MC, Muller S, Wendling O, Herault Y, Mark M
Curr Protoc Mouse Biol. 2011 Mar 1;1(1):17-53.

View on Pubmed


Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas.

Mutel E, Abdul-Wahed A, Ramamonjisoa N, Stefanutti A, Houberdon I, Cavassila S, Pilleul F, Beuf O, Gautier-Stein A, Penhoat A, Mithieux G, Rajas F.
J Hepatol. 2011 Mar;54(3):529-37.

View on Pubmed


TASK-3 as a potential antidepressant target.

Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K, McCampbell A, Stevens J, Brunner JI, Fox SV, Uebele VN, Bayliss DA, Winrow CJ, Renger JJ.
Brain Res. 2011 Oct 6;1416:69-79.

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The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.

Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y
Behav Brain Res. 2011 Mar 1

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TIF1beta association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis.

Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, Cammas F.
Dev Biol. 2011 Feb 15;350(2):548-58.

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Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.

Caberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prévot O, Chardenoux S, Do Cruzeiro M, Hardelin JP, Richardson GP, Avan P, Weil D, Petit C.
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30.

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