Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

Knock-in (KI) models are used to introduce either a mutation in a specific gene or an additional DNA sequence.

Advantages

  • Multiple applications: human disease recapitulation, compound efficacy assessment, promoter activity study, mutant protein expression, cell trafficking following by marker gene introduction, gene replacement by reporter gene, humanization.

Drawbacks

  • Modification of human orthologue proteins in mouse may not completely reflects the role of a gene in human pathology.

Recommended technics

Depending on your project and objectives, KI animals can be obtained through

PHENOMIN expertise

  • Personalized genome engineering service to fit our customer needs.
  • Implication in international consortia (near 20 different consortia) to benefit from the last technics and scientific expertise.
  • Continuous R&D activity to improve our technics and success rate and propose our customers the best approach for their projects.