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Knock-in (KI) models are used to introduce either a mutation in a specific gene or an additional DNA sequence.



  • Multiple applications: human disease recapitulation, compound efficacy assessment, promoter activity study, mutant protein expression, cell trafficking following by marker gene introduction, gene replacement by reporter gene, humanization.


  • Modification of human orthologue proteins in mouse may not completely reflects the role of a gene in human pathology.

Recommended technics

Depending on your project and objectives, KI animals can be obtained through

For KI models generation request please contact us

PHENOMIN expertise

  • Personalized genome engineering service to fit our customer needs.
  • Implication in international consortia (near 20 different consortia) to benefit from the last technics and scientific expertise.
  • Continuous R&D activity to improve our technics and success rate and propose our customers the best approach for their projects.