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Humanization models are specific models in which a human sequence or material has been introduced (gene replacement, point mutation, BAC transgene injection or even graft models). These models are used to mimic a human pathology or to evaluate a drug effect on human proteins; they are often used to study cancer, inflammatory and infectious diseases and hematopoiesis.

Advantages

  • The human protein is expressed under physiological conditions, using mouse promoter and regulatory regions

Drawbacks

  • Model design is complex to preserve physiological expression and regulation of the human gene inserted into the mouse genome

PHENOMIN expertise

  • Personalized genome engineering service to fit our customer needs
  • Implication in international consortia (near 20 different consortia) to benefit from the last technics and scientific expertise
  • Continuous R&D activity to improve our technics and success rate and propose our customers the best approach for their projects