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Our scientific results totally rely on animals, that's why PHENOMIN is involved in ethics and welfare. Every day, we do respect, as sensitive beings, animals we are working with. PHENOMIN assesses animal welfare for good science.
"Good animal care and good science go hand in hand".
(National Institutes of Health (U.S.). Animal Research Committee)
As the study of biology and diseases is done on complete living organisms, animals have been used for hundreds of years to improve human knowledge. Thanks to biology, medicine and physian researchers implicated in animal research, the understanding of diseases and the discovery of new treatments have been far improved. It is only since the nineteenth century that the use of animal in scientific research has become a societal debate, with the development of associations for the protection of animal rights. In parallel with this societal change, the regulation has also evolved.
Recently the CNRS has published a short video to summarize the regulation's evolution (in French langage).
Since 2013 in France, as throughout Europe, animal research has been practiced according to the European Directive 2010/063/EU of September 23, 2010. Projects involving animals have to be justified at the ethics committees and approved by the Ministry of Research before being implemented in the field.
The phenotypic analyzes consist in carrying out a complete health check of the mice, as would be done for a fifty-year-old in the hospital, emphasizing the management of the stress and the pain. Blood tests or ultrasounds, for example, are carried out under anesthesia to minimize the stress induced by these acts.
In the present state of knowledge, the complexity of mammalian organisms makes the use of animal in research crucial.
With its similarity to human biology and ease of genetic modification, the laboratory mouse is arguably the preferred model organism for studying human genetic diseases. Characterizing the mouse genome reveals new gene functions and their role in human diseases. The International Mouse Phenotyping Consortium (IMPC)* is aiming to produce a complete catalogue of mammalian gene functions. The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, based on an analysis of the first 3,328 genes (15% of the mouse genome coding for proteins) and revealing new insights into a range of rare diseases and the possibility of accelerating the development of new treatments and precision medicine (published in Nature Genetics, June 2017).
However, fundamental research studies, such as phenotyping, enrich the knowledge that will enable, in the near future, to develop more reliable in vitro or even in silico models and thus reduce the use of animal experiments without affecting the quality of the work of scientists.
PHENOMIN subscribes and supports the Basel Declaration, a call for more trust, transparency and communication on animal research adopted on November 29, 2010 on the occasion of the first Basel conference «Research at a Crossroads» organized by the "Basel Declaration Society" (BDS). The purpose of the «Basel Declaration Society» is to strengthen public awareness of the importance of animal models in experimental biomedical research, to foster communication between researchers and the public, and to enhance acceptance of the Basel Declaration. Like the Helsinki Declaration, which forever altered the ethical landscape of human clinical research, the aim of the «Basel Declaration Society» is to bring the scientific community together to further advance the implementation of ethical principles such as the 3Rs whenever animals are being used in research.
In addition to ethical principles, PHENOMIN has also established a list of good practices to assess the animal welfare of each of our laboratory rodents which is crucial in case of harmful phenotype.
Because of the lack of information, the public poorly understands the reasons and the conditions in which it is practiced. This sometimes results in misunderstandings and misconceptions. Gircor, the French interprofessional research think tank and communication group, bringing together the biological or medical research institutions in France, addresses the need for clear and transparent information.By informing on current research, Gircor outlines and explains the conditions under which animal research is practiced. At the public’s disposal, Gircor answers the questions anyone has: https://www.recherche-animale.org/en/about-us
In February 2021, the Gircor has just published a Transparency Charter on the use of animals for scientific and regulatory purposes signed by several entities of the scientific community in France, including PHENOMIN. This is the first Commitment to Transparency and Openness for Animal Research in France. PHENOMIN is committed to ensuring better transparency by informing on current research and by giving the opportunity to understand the place of the animal models in scientific and biomedical research's progresses, and finally by explaining the conditions under which animal research is practiced.
The French initiative will strengthen the overall vision shared with many European countries and many scientists to support transparency for animal research.