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Latest News

Nov. 19, 2019 CONFERENCES

The sex gender on the consideration of the 3Rs rules in animal research experimentations

As part of its annual meeting, the French research infrastructure CELPHEDIA invite you to attend the open conferences related to the impact of the sex gender on the consideration of the 3Rs rules in animal research experimentations. The IMPC data has demonstrated the effect of sex on many phenotypes, supporting the importance of including males and females in biomedical research. It is therefore clearly a crucial topic to highlight in CELPHEDIA's missions. PHENOMIN's team will be present to debate. This issue will be discussed on November 20th Afternoon, at the auditorium Merieux, ENS, Lyon with examples of unexpected sexual dimorphism, a presentation on multi-parametric data analysis, and a philosopher's perspective on the importance of refining protocol design.

Free registration: https://celphedia.sciencesconf.org/ 

 


Oct. 14, 2019 ANNOUNCE

Favourable evaluation of PHENOMIN !

The international jury convened by the ANR makes a very favourable evaluation of PHENOMIN

On the June 16th, 2019, the PHENOMIN infrastructure defended its activity report for the period 2011-2018 and its proposal for 2020-2024 in front of an international jury convened by the ANR. After 15 minutes of presentation, an in-depth discussion on progress and future developments continued between the 3 PHENOMIN representatives and the panel of experts for 45 minutes. The evaluation of PHENOMIN was sent to us in August 2019 with the following general comment:

The face-to-face meeting with representatives of the PHENOMIN supported the excellent report/application and the panel can state that PHENOMIN is mature, excellent research infrastructure of great importance to research community of France and with global impact. PHENOMIN has already provided. Representatives of the RI explained also the PHENOMIN’s further development within the CELPHEDIA, where the PHENOMIN should take a lead as a central element, increasing its impact scientific community working with animal models, also other than rodents, thus disseminating their knowledge and expertise over the broad French and international research community.”

The Directors of the PHENOMIN Centres, as well as all the managers of work programmes, would like to thank and congratulate all their colleagues for this evaluation which will commit us to a new period of activity of 5 years to serve the scientific community.

We will all face new challenges and as Centre Directors we are confident that we can meet them together to provide better services and new tools to the scientific community.

 


Aug. 27, 2019 CITIZEN SCIENCE PROJECT

Secret lives of mice- Citizen science project

Our colleagues at MRC Harwell have worked together with Actual Analytics in order to develop the Home Cage Analysis system (HCA), which provides provides 24/7 monitoring of rodent behaviours in a group-housed environment that is beneficial from both data and welfare perspectives. The challenge was initially proposed by the NC3Rs CRACK IT initiative and finally results to the exciting citizen science project “Rodent Little Brother: Secret Lives of Mice “ . The project was launched in early july, this summer.

People contributes to help scientist to get a computer algorithm to track and annotate mouse behaviour for them, getting involved in a project that has the potential to refine experimental procedures and finally to change the way mice and other animals are studied in the laboratory.

To get informed and involved in the project, visit the Rodent Little Brother Home Page.


June 20, 2019 MOUSE GENE ANNOTATION

IMPC's strategy 2021-2030

The International Mouse Phenotyping Consortium’s (IMPC) 10-year strategy presents a bold ambition for the future functional annotation of the genome and deciphering genetic variation in the context of gene function and disease. 2020 will mark the 10th anniversary of the consortium, and then IMPC presents a strategy that encompasses completion of Phase 2, and execution of Phases 3 and 4. PHENOMIN, which has come with other partners to produce this strategy, is really proud of its involvement to this huge project since its inception as a leader from mouse genetics centres across the world.

The 6 key goals of IMPC for 2021–2030 is to deliver broad-based genomic insights into the function of human genetic variation in both coding and non-coding sequences that underpins future developments in precision medicine, rare disease, clinical genetics, and healthy living. This strategy document includes a statement on the underpinning rationale for how mouse genetics and mouse models inform gene function, human disease, and clinical genetics and a clear description fo each key goals.

  • Complete the generation of a null mouse mutant resource for the coding genome
  • Design and produce a genome-wide mouse strain resource of human disease-associated coding variants
  • Design and generate mouse strains that model genetic variation in the non-coding genome
  • Phenotype mouse strains with null mutations, human-disease coding variants, and variants in the non-coding genome to provide a comprehensive catalogue of baseline information on mammalian gene function
  • Explore genetic context to realise the wider potential for mouse functional studies
  • Develop data integration, analysis, and visualisation approaches to translate mouse functional genomics studies to the human gene and disease knowledge base and vice versa

You will find the stategy document on the the new, redesigned website of the IMPC which provides a great user experience !


June 11, 2019 CONGRESS

FELASA 2019, now in progress

FELASA, the Federation of European Laboratory Animal Science Associations, represents over 4000 specialists in the field of laboratory animal science from 28 countries and 21 constituent associations.This triennial congress has grown to become the largest European laboratory animal science event attracting almost 2000 participants. This congress is always organized together with one of the FELASA Constituent Associations, which gives us all a great opportunity to familiarize ourselves with the cultural features of different countries in Europe. This time our host will be CLASA, Czech Laboratory Animal Science Association.

The FELASA Congress is a scientific and educational event, offering the current knowledge on the use and welfare of animals in experiments and how to make improvements in these areas: in Prague, a special issue will be the correct reporting of animal research. Animal welfare, ethical aspects, legislation and education are obvious parts of congress topics. We will also have the newest information and recommendations on how to working with aquatics and some other rarely used species.

FELASA Congress is not only science and education. It is also a large exhibition, showing the recent updates in animal care materials and equipment, animal use and health programs, and research equipment. You will have the opportunity to talk with the representatives from the companies exhibiting, and get information on all new equipment, techniques and almost everything needed when working with laboratory animals.

And finally – professional and social contacts are something invaluable in a face-to-face environment. This is an integral part of the FELASA Congress: meeting colleagues from all over Europe – and beyond – renewing old and making fruitful new acquaintances by means of informal conversations.

The FELASA Congress is the perfect occasion to combine continuing education with informal exchanges of ideas.

A. AYADI, from PHENOMIN-ICS is attending the meeting


June 3, 2019 CALL

Call for proposals - specialized phenotyping

INFRAFRONTIER2020 project - Trans-national Access call for proposals (June 2019)

The INFRAFRONTIER mouse clinics offer the examination of mouse mutants using a broad and standardised phenotypic check-up covering key research areas such as behaviour, clinical chemistry, immunology, energy metabolism, and lung function amongst others. If phenotypes are uncovered by the primary assays, mouse mutants can be subjected to more detailed analyses in hypothesis driven and disease focussed phenotyping pipelines.

In this specialised phenotyping call we provide access to a comprehensive panel of phenotyping tests, relying on standardized and customized protocols in key therapeutic areas. There are 2 proposals:

The second one is proposed by PHENOMIN-CIPHE. Please find below the application form :

Download


May 21, 2019 PATHBIO SCHOOL

Last day to register !

PATHBIO, Precision Pathobiology for Disease Models, is happy to announce the course will be offered from July 15-26, 2019 in Barcelona. The first course on Mouse Embryology, Anatomy, Histology, and anatomical basis of Imaging will take place in the Veterinary School at the Universitat Autònoma de Barcelona (www.uab.cat). The aim is to provide graduate, master, PhD and postdoc students with basic and expert knowledge to phenotype morphologically mouse models of human diseases.

PHENOMIN-ICS is involved in this nice course programme.

There is no fee for this course. Participants have to organize travel and accommodation themselves and cover the corresponding expenses. Interested participants should apply with CV and letter of motivation to Jesús Ruberte (jesus.ruberte@uab.es). Deadline for applications is May 31st, 2019. Accepted participants will be informed middle of June.

Download


May 21, 2019 WEBINAR ANNOUNCE

More parameters, more informative phenotypes: Systematic phenotyping approaches - Sign up for the webinar at May 22nd

Sign up now for the latest Wiley Webinar: Dr. Hervé Luche, PHENOMIN-CIPHE presents new techniques for more parameters, more informative phenotypes: Systematic phenotyping approaches;

with its cutting-edge expertise in mouse genetics and immunology, PHENOMIN-CIPHE aims to develop and analyze, in a massively parallel and standardized mode, mouse KO/KI models, to understand the function of the mouse immune system under normal and infectious conditions. CIPHE has the unique ability to phenotype all the cellular components of the immune system, under normal conditions or confronted with pathogens by, integrating current cutting-edge research and technical knowledge in cytometry.


May 17, 2019 OPEN REGISTRATION

The registration is now open for IMGC 2019 in Strasbourg France, September 25-18, 2019!

The 33rd edition of the annual conference of the International Mammalian Genome Society is held in Strasbourg, France !

We welcome you to the PHENOMIN-ICS and IGBMC ! We are planning an exciting meeting on mammalian genetics and genomics. The perpetual evolution of mammalian genomics is the main focus of IMGS' annual conferences. The meeting will begin with five Workshops followed by a Student Satellite Symposium that offers the opportunity for scientists to compete for awards and presentation slots in the main meeting. Indeed, most of the talks are selected from submitted abstracts and there are poster presentations as well ! The conference will once again include the popular mentoring lunch where those looking for career advice can interact with established scientists.

The window to register is limited -- abstract, registration and IMGS scholarship application deadline is June 16 !

Limited places available, so register early to save your spot !

For more details, please see https://imgc2019.sciencesconf.org/ 

Then, do not hesitate, and register as soons as possible ! We look forward to welcoming you to Strasbourg and the 33rd International Mammalian Genome Conference!<o:p></o:p>


April 11, 2019 ANNOUNCE

PATHBIO - 1st summer school

PATHBIO, Precision Pathobiology for Disease Models, is happy to announce the course will be offered from July 15-26, 2019 in Barcelona. The first course on Mouse Embryology, Anatomy, Histology, and anatomical basis of Imaging will take place in the Veterinary School at the Universitat Autònoma de Barcelona (www.uab.cat). The aim is to provide graduate, master, PhD and postdoc students with basic and expert knowledge to phenotype morphologically mouse models of human diseases.

PHENOMIN-ICS is involved in this nice course programme.

There is no fee for this course. Participants have to organize travel and accommodation themselves and cover the corresponding expenses. Interested participants should apply with CV and letter of motivation to Jesús Ruberte (jesus.ruberte@uab.es). Deadline for applications is May 31st, 2019. Accepted participants will be informed middle of June.

Download



Upcoming events

TRAINING COURSE

Mouse embryology: practical training course

March 10 - 12, 2020, Strasbourg, France

Objectives

  • Acquire primary expertise in mouse development
  • Be able to design primary phenotyping experiment on mouse embryos
  • Learn about all the primary phenotyping analysis on mouse embryos
  • Be able to dissect post-implanted embryos
  • Be able to determine the window of lethality in utero
  • Be able to evaluate embryos viability at neonatal stage
  • Increase awareness of relevant technics to image embryos

Organisation:

  • From 6 to 8 attendees
  • Dead line registration : 2020 Jan 28th (6 weeks before starting animal breeding)
  • Acces to detailed program and registration
  • CNRS formation entreprises
  • PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)

 

More information at https://cnrsformation.cnrs.fr/stage-20234-Mouse-embryology-practical-training-course.html?mc=embryologie


TRAINING COURSE

Flow cytometry webinar

March 10 - October 1, 2020, on line

Flow cytometry is an analytical method to deeper understand the immune system, and precisely by ensuring the detection of complex panel of proteins at the surface of immunological cells for precise phenotyping. For further insight we are pleased to present this ThermoFischer-hosted webinar presented by H.Luche from PHENOMIN-CIPHE

More parameters, more informative phenotypes: Systematic phenotyping approaches - Replay is available on line.

We offer high-throughput solutions for immunity profiling and characterization of your model. This includes the advanced multiparametric flow and mass cytometry approaches onvolving a series of over 200 parameters to phenotype all the cellular components of the immune system. These parameters are combined in one single illustration (immune signature) to provide a more robust way to investigate a phenotype. For any scientific, technological or strategy guidance, please do not hesitate to contact PHENOMIN experts.

More information at http://www.phenomin.fr/en-us/contact/


TRAINING COURSE

2nd PATHBIO IMAGIN(E)G MOUSE MASTER CLASS in 3Rs

September 21 - 25, 2020, Strasbourg, France

PATHBIO IMAGIN(E)G MOUSE MASTER CLASS in 3Rs consists of one of the three intensive courses from PATHBIO consortium. The PATHBIO project brings together an ERASMUS+ Knowledge Alliance consortium from across the globe to cooperate on pooling resources and expertise in order to build the framework for a European post graduate degree in Precision pathobiology for disease models.

Objectives

  • Learn more about basic and expert knowledge to image mouse models of human diseases
  • Hear about current advances on many technical aspects from structural to functional imaging
  • Highlight crucial issue in your own scientific project.

Have a look to the 2019 Programme !

In 2020, the Imagin(e)g mouse master class  will take place in Strasbourg again, from the 21th to the 25th of September (from Monday morning to Friday afternoon).

The course is free to participants. SAVE THE DATE  !

Further information about course content may be found on http://www.pathbio.org/index.php or contact info@pathbio.org.

 

PATHBIO is an EU-funded ERASMUS Knowledge Alliance for “Precision Pathobiology for Disease Models”. The program is supported by INFRAFRONTIER and IMPC.

More information at http://pathbio.org/


TRAINING COURSE

In vivo CRISPR-Cas9 genome editing

October 8 - 9, 2020, Strasbourg, France

More information at https://cnrsformation.cnrs.fr/stage-20213-In-vivo-CRISPR-Cas9-genome-editing.html?mc=CRISPR


TRAINING COURSE

WEBINAR Series: Transgenic Mouse and Rat Model Creation

November 1 - January 1, 2020, on line

CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted and Labroots-hosted webinars presented by G. Pavlovic and M-C Birling from PHENOMIN-ICS

PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.

More information at http://www.phenomin.fr/en-us/contact/