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INFRAFRONTIER Research Infrastructure / INFRAFRONTIER2020 Project - Trans-national Access call - January 2019

Precision rat model development

This Trans-national Access call of the INFRAFRONTIER2020 project supports a total of 3 precision rat model development projects. A complementary call provides support for 12 customised mouse model development projects.

• Free-of-charge rat model development service implemented as a Trans-national Access activity supporting a total of 3 projects in this call.
• The access unit offered covers the production of a single F1 genome-edited rat line (at least one individual of a F1 genome edited rat line will be provided).
• The model development service using genome editing involves project design, preparation of sgRNAs and Cas9 mRNA/protein, and injection into zygotes to generate F0 founder mutant animals (Sprague Dawley genetic background).Selected F0 animals (very often mosaic) will be bred to germ line to produce F1 genome edited animals. Possible allele types that can be generated are indels, exon deletions (< 10kb) and point mutation insertions.

In collaboration with PHENOMIN-ICS

Proposal submission to proposals@infrafrontier.eu by 15 February 2019. (Proposal evaluation from 15 February 2019 to 15 March 2019)

More information and call application on the website

In a Trans-national Access Call, Infrafrontier offers a service to derive germ-free mice for European researchers who study the role of the microbiome in metabolism, physiology, and immune function.

The `axenic´ service is free of charge. Access to the axenic service will be granted on the basis of scientific excellence and supports pilot projects for the derivation of-germ-free mice. Further breeding and characterisation of axenic mice or the development of gnotobiotic models can be offered on a fee-for-service or on a collaborative basis.

in collaboration with PHENOMIN-TAAM.

Deadline for submission of proposals: 31 January 2019

All details on website. 

 

The 31^st January 2019, PHENOMIN attends the French day meeting dedicated to the effectiveness of in vivo substance administrations in animal models! This symposium is organized by the French AFSTAL association;

PHENOMIN-TAAM will present our imaging capabilities in the small animal models !

A. Lepape, will orally present "Plan de circulation - La diffusion des substances dans l'organisme" and A. Diet invites you to visit the PHENOMIN's booth to discuss your projects and needs.

Join us !

Would you like to learn more about mouse functional genomics to improve your research?

• Discuss your work in progress and receive advice on experimental design issues
• Benefit from state-of-the-art expertise and innovative methods
• Gain crucial skills required to choose, create and analyse the suitable mouse model for your research
• Learn how to use the available resources from the international projects
• Gain personnal connections with experts and peers throughout Euro

PHENOMIN's school provides the unique opportunity for you to discuss their research in detail with experts as well as peers.

• Connection between doctoral education and international research projects
• Theory and workshops
• Networking and socialising

Do you expected concrete changes in the management of your experimental projects, in your animal facility, in the analysis and interpretation of the model data you use ?

This event is for you: https://advanced-school.phenomin.eu/

Have a look to the schedule program of the PHENOMIN school conisting of workshops on case study in order to support you in your model choice, phenotyping, taking into account the animal welfare. The program also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.

We will be delighted to welcome you !

Guillaume Pavlovic, PHENOMIN-ICS, will present a Webinar in collaboration with our partner Charles River 

The topic: While the power CRISPR/Cas9* has to achieve targeted mutations in nearly any species is clear, what conclusions can we truly draw about its use in genome editing? Attend our webinar, where we’ll answer this question and more with topics including:

• Is genome editing safe and efficient for human therapy?
• Will CRISPR help us rid the world of mosquitos, or find the cure for AIDS?
• How to best expand research applications using deadCas9 protein?

*CRISPR/Cas9 used under license to granted and pending US and international patents from ERS Genomics Limited.

Have a scheduling conflict? Sign up even if you can't make it; we'll share the recording after.

Registration 
 

 

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Upcoming events

G. Pavlovic, head of the genetic engineering department of PHENOMIN-ICS, had presented a serie of webinars:

• CRISPR/Cas9: The Good, The Bad and The Ugly- Replay is available on line.
• Modelling Human Disease in Rodents with CRISPR/Cas9 Genome Editing -Replay is available on line.
• The Cre-Toolbox: Revealing Gene Functions with Cre-lox Recombination -Replay is available on line.
• CRISPR/Cas9 Genome Editing: Model Creation, Gene Therapy, and Beyond -  Replay is available on line by this specific link.

PHENOMIN works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.

More information at https://www.criver.com/resources/webinar-series-transgenic-mouse-and-rat-model-creation

POSTPONED TRAINING !

Objectives

• Acquire primary expertise in mouse development
• Be able to design primary phenotyping experiment on mouse embryos
• Learn about all the primary phenotyping analysis on mouse embryos
• Be able to dissect post-implanted embryos
• Be able to determine the window of lethality in utero
• Be able to evaluate embryos viability at neonatal stage
• Increase awareness of relevant technics to image embryos

Acces to detailed program and registration

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)

 

More information at https://cnrsformation.cnrs.fr/stage-19219-Mouse-embryology-practical-training-course.html?axe=109

Click here to download the attachment.

Objectives

• To prepare and design your experiments using ddPCR
• To understand the advantages and limitations of ddPCR
• To use ddPCR technology to detect CNVs (copy number variation)

Audience

• Researchers and experienced technicians
• Limited number of attendees: 6

The course is conducted in french- Collaboration between PHENOMIN-ICS and Bio-Rad Europe

PHENOMIN's contact:  bedu@igbmc.fr

Click here to download the attachment.

Would you like to learn how to choose, create and analyse your best mouse model?

Do you have a sufficient background in mouse functional genomics to lead as best your research?

PHENOMIN, in collaboration with Infrafrontier, supports researchers who use mouse models by giving us the opportunity to take part to the biennial Edition of the Advanced School in Mouse Phenogenomics.

• Come to the heart of Europe to be involved - together with other students and researchers from all over the world - in opened discussion, in constructive analysis of your own research and in building conceptual scientific advances.
• The school covers the different fields of mouse phenogenomics, ranging through 5 topics from state-of-the-art mouse genetics, mutagenesis, mouse colony management, phenotyping human diseases and data management (statistical approaches).
• This unique international event will provide the attendees with a wealth of information on good practices in the use of mouse model (experimental design, ethics, regulations, analysis, data and resources ...) to support attendees in their research.

More information at https://advanced-school.phenomin.eu/

Objectives:

• Become aware of the importance of traceability and quality control in cell culture
• Understanding the issue of cell culture contamination
• Become aware of the diversity of mycoplasma detection methods and be able to choose the techniques adapted to each case
• Know how to prevent contamination and what attitudes to adopt in the event of proven contamination

The course is conducted in French- Acces to program and registration 

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/stage-19212-Les-contaminations-dans-les-cultures-cellulaires.html?mc=contamination