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Latest News

Aug. 19, 2021 INVITATION

Conference and abstract submission invitations

The ‘Mouse Genetics and Genomic Medicine’ is a virtual conference organised by the International Mouse Phenotyping Consortium – IMPC (https://www.mousephenotype.org) to celebrate the occasion of the 10th anniversary of the establishment of the IMPC.

PHENOMIN is part and  invite you to joiun us !

  • The conference is hosted virtually on 23-24 September 2021
  • Registration is FREE for all participants.Registration online; Registrants will be receiving the CONFERENCE WEBCAST LINK 3 days before the beginning of the Virtual Conference along with the unique passcode to log on to the Digital conference webcast platform.
  • ABSTRACT SUBMISSION INVITATION :The Organizing Committee invites the submission of abstracts for poster presentation at the International Conference ”Mouse Genetics and Genomic Medicine” on 23 and 24 September 2021. Corresponding authors must fill out the contact form and follow the guidelines. Abstracts not following these Guidelines will not be considered as valid.Submission deadline of Abstracts is Friday, 10 September 2021.
  • Scientific program :Distinguished scientists from all over the world will participate as guest speakers according to the Scientific Program


For more information, please visit the IMPC Virtual Conference Website


July 15, 2021 INVITATION

Save the date for the CCP Conference 2021 !

"Dear Colleagues,

It is my great pleasure to invite you to the third CCP Phenogenomics Conference. This year, the conference will be a virtual meeting due to the continuing uncertainty about travel.

The scientific committee has selected two main thematic focuses.

  • The first day will be dedicated to immunology, infectious diseases, and human diseases models. Among other interesting topics, this day will of course cover Covid-19 related research and the translation of basic research results into application.
  • The second day is specifically dedicated to preclinical development and advances in neuroscience.

Even though, taking place only in a virtual environment, we believe that the Conference will provide an excellent opportunity to support networking and interactions among the CCP users and experts.

We are looking forward to meeting you virtually in September 2021.

Yours sincerely,

Radislav Sedlacek
Director of the Czech Centre for Phenogenomics
Institute of Molecular Genetics of the Czech Academy of Sciences"


June 10, 2021 LATEST NEWS

PHENOMIN Newsletter June 2021

We invite you to browse through our latest newsletter, whose main topics are

  • LATEST NEWS from PHENOMIN 2021
  • DESIGN AND DATA ANALYSIS: OUR VISION
  • OUR last RESEARCH SPOTLIGHT
  • OUR RESOURCES and NETWORKS, great support for your research !
  • UPCOMING EVENTS & TRAININGS....including the Special one for the 10th anniversary of PHENOMIN !

Have a look !

 


June 1, 2021 NEWS

Understanding the onset of congenital anomalies: useful annotated 3D representations of mouse embryos

Congenital anomalies (CA) affect 1 in 33 infants worldwide and result in approximately 3.1 million birth defect-related disabilities every year. CA are generally diagnosed only after birth or, more rarely, at late stages of pregnancy. Yet, most of them are determined early during the very first weeks after fertilization. To better understand the pathogenesis of CA at early embryonic stages, researchers from IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) and PHENOMIN-ICS (PHENOMIN-Institut Clinique de la Souris) proposed to compare three-dimensional (3D) reconstructions of mouse embryos carrying known mutations with their normal littermates at the start of appearance of the different organs. They are first aiming to compare mouse embryos at embryonic day 11.5 (E11.5) which are very similar to human embryos at the 6th week of gestation.

3D imaging is a useful tool to characterize morphological phenotypes, but also to describe the normal anatomy of embryos for educational purposes. Therefore, as a start, the researchers provide to the scientific community the first annotated 3D representation of E11.5 mouse embryo using HREM (high resolution episcopic microscopy). This technology generates images that are comparable to histology in terms of resolution: it allows visualizing the surfaces and volumes of internal organs and cavities, in the nervous system, heart and vasculature, primitive gut, and urogenital system. Each image content is detailed and annotated, inspired by the texts of Karl Theiler[1] (1972) and Matthew Kaufman[2] (1992).

This innovative educational material was developed as part of our participation in the PATHBIO consortium, which aims at designing and developing a series of innovative materials destined for teaching the anatomy, histology, embryology, imaging and pathology of the mouse. We are pleased that it is now freely available online.

And congratulations to the teams!

 

[1] Karl Theiler, The House Mouse © Springer 1972

[2] Matthew H. Kaufman, The Atlas of Mouse Development © Academic Press 1992

 


April 15, 2021 RESEARCH SPOTLIGHT

A resource of targeted mutant mouse lines for 5,061 genes (Nat Genet. 2021)

This April, an article in Nature Genetics highlights the major contribution of PHENOMIN-ICS in the International Mouse Phenotyping Consortium (IMPC) for the implementation of a comprehensive quality control strategy for alleles in targeted embryonic stem cell clones produced by high throughput. More than 5000 resulting mouse lines were generated with these ES cell clone through a collaborative effort of the different IMPC centers. All of them have the great advantage of having been established in the same C57BL/6N genetic background. Almost 3,700 have a versatile allele that has the advantage of being able to be transformed either into a conditional knockout or into a knockout bearing a LacZ reporter gene. The conditional allele remains a tool of choice for all scientists wishing to perform more detailed analyzes. The total number of genes with a potential conditional allele has been nearly doubled thanks to the effort of the IMPC.

The ultimate goal of IMPC is to generate and phenotype in a standardized manner the KOs of all protein-coding genes to provide key information for the biology and understanding of the development of human diseases. We were able to show that 72% of the KO lines show at least one phenotype, thus revealing a significant pleiotropy. This proportion includes the 39 % showing partial or total lethality. Thanks to this tremendous effort, almost half of the genome is now targeted. Since 2015, the production of KOs from ES cells has been replaced by simple KOs obtained by CRISPR / Cas9 technology. However, in the new era of genome editing, this ES cell-derived collection remains of unique value, as it offers particularly sophisticated and quality-controlled alleles representing a cornerstone of the collective development of a resource of null allele for the complete genome of mammals.

Marie- Christine Birling et al., 2021 - Nat Genet.

 

 

 


March 9, 2021 FREE LEARNING EVENTS

Health and safety of your model colonies: webinar event !

Do you want to take advantage of our expertise to manage the health and safety of your favorite models and to improve data reproducibility ?  Take the “fast track” towards protecting the health and safety of your model colonies with the Charles River's upcoming “Quick Insights in Animal Health” event in which PHENOMIN-ICS will share crucial information through the various presentations of track  3 and 6. The free learning series features short, on-demand presentations (each no more than 15 minutes) across six different tracks.

See you online, March 29th !

 


Feb. 25, 2021 NEWS

A Commitment to Transparency and Openness for Animal Research in France

The French interprofessional research think tank Gircor has just published a Transparency Charter on the use of animals for scientific and regulatory purposes signed by several entities of the scientific community in France, including PHENOMIN.

PHENOMIN is committed to ensuring better transparency by informing on current research and by giving the opportunity to understand the place of the animal models in scientific and biomedical research's progresses, and finally by explaining the conditions under which animal research is practiced.

The French initiative will strengthen the overall vision shared with many European countries and many scientists to support transparency for animal research.

Download


Feb. 9, 2021 JOB OPPORTUNITY

The PHENOMIN- ICS centre is recruiting- Come and join us !

IT Development Manager M/F - CDI

Reference: IGBMC / IT-16

IGBMC, one of Europe's leading biomedical research centers counting 700 employees of 45 nationalities and 47 research teams focusing on the study of human pathologies such as cancer and genetic diseases. The Mouse Clinical Institute (Institut Clinique de la Souris - iCS), the IGBMC's largest technology platform, is ISO 9001 and NFX 50-900 certified. It is the leading center of the national infrastructures PHENOMIN and CELPHEDIA and a key player in the European and global effort to annotate the mouse genome via the INFRAFRONTIER and IMPC consortia.

The IGBMC campus is located on the Illkirch Innovation Park in the suburbs of Strasbourg, France, an exceptional academic and industrial scientific environment that strongly favors collaborations and technology transfer.

For its activities the iCS relies on its IT Development Manager (M/F).

A permanent position to be filled as soon as possible

See the offer

Download


Jan. 18, 2021 RESEARCH SPOTLIGHT

Investigation of the role of Macrophages in the integrity and function of the colon epithelium in homeostasis

Maintenance of the intestinal barrier is critical given that it controls the absorption of nutrients, electrolytes, and water from the gut lumen into the blood circulation and further prevents the absorption of toxicluminal substances. Macrophages contribute not only to eliminating pathogens but also to the good functioning of most tissues of the human body (management of dead cells, healing, and maintenance of cardiac functions, arterial and neuronal). PHENOMIN-CIPHE has developed an innovative model of knock-in mice which has been used to induce Macrophages depletion (CD64DTR model). The research teams from the Institut Curie (Paris, France) used it to study role of Macrophages in the integrity and function of the colon epithelium in homeostasis. Authors show that sub-epithelial Macrophages perform a rapid quality check of the fluids absorbed through distal colon epithelial cells, protecting them from being poisoned by luminal fungal metabolites.

Chikina A S et al, 2020 –Cell


Dec. 23, 2020 OPEN CALL

15th Call for proposal - INFRAFRONTIER

COVID-19 research with mouse disease models

We are excited to inform you about INFRAFRONTIER´s new free-of-charge TA Call: COVID-19 Therapeutics Pipeline. Our goal is to provide extensive user support to the selected projects for assessing novel potential vaccine and treatment candidates for COVID-19. The TA service is covered by the INFRAFRONTIER2020 project (Horizon 2020). 

INFRAFRONTIER partners (PHENOMIN-CIPHE and CCP) will execute this call by providing viral particles, COVID-19 mouse models, cohort production, and BSL3 pipeline analysis. Further functional analysis and advanced readouts like organ histopathological analysis, multiplex assay profiling of cytokines and chemokines in lung and mouse serum, etc. can be provided on a collaborative basis outside the TA call scope. 

  • Application form: Please fill in the application form and send it to proposals@infrafrontier.eu
  • Application deadline: 31 January 2021
  • Application costs: This TA Call is free-of-charge for the selected applicants.
  • Please contact info@infrafrontier.eu if you have any questions.

For more information about this project and about how to apply please visit our website

For further questions please write to us: proposals@infrafrontier.eu

 



Upcoming events

SPECIAL EVENT

Mouse Genetics and Genomic Medicine Conference

September 21 - 23, 2021, Online

The ‘Mouse Genetics and Genomic Medicine’ is a virtual conference organised by the International Mouse Phenotyping Consortium – IMPC (https://www.mousephenotype.org) to celebrate the occasion of the 10th anniversary of the establishment of the IMPC.

  • The conference is hosted virtually on 23-24 September 2021
  • Registration is FREE for all participants.Registration online; Registrants will be receiving the CONFERENCE WEBCAST LINK 3 days before the beginning of the Virtual Conference along with the unique passcode to log on to the Digital conference webcast platform.
  • ABSTRACT SUBMISSION INVITATION :The Organizing Committee invites the submission of abstracts for poster presentation at the International Conference ”Mouse Genetics and Genomic Medicine” on 23 and 24 September 2021. Corresponding authors must fill out the contact form and follow the guidelines. Abstracts not following these Guidelines will not be considered as valid.Submission deadline of Abstracts is Friday, 10 September 2021.
  • Scientific program :Distinguished scientists from all over the world will participate as guest speakers according to the Scientific Program

More information at https://impc2021.com/index


MEETING

Virtual MACS® Genomics Day 2021

September 23, 2021, Online

Join us in the virtual event that will bring together the genomics community to exchange knowledge on performing genomic analyses, with a special focus on single-cell genomics. Our agenda is full of exciting scientific talks covering recent findings in various disciplines of biology and presentations on latest technology innovations by our collaboration partners 10x Genomics and Illumina.

Take the opportunity to interact with your peers during our networking session, get connected with speakers, and participate in live demos. Moreover, the MACS Genomics Day is a platform to get your questions about sample preparation and single-cell sequencing answered! Our technical experts will be there and assist you to excel your genomic analysis. 
 

PHENOMIN-CIPHE will be part; H. Luche will present "Immuno-profiling of murine preclinical tumor models in the multi-omic era. A way to improve translational prediction for immune-based therapeutics"


The event will be hosted at the online platform Remo. Please find technical information below on this page. 
Register for free to save your spot! 

More information at https://www.miltenyibiotec.com/FR-en/about-us/conferences-and-events/macs-r-genomics-day.html


TRAINING COURSE

3rd Imaging PATHBIO master class

September 27 - October 5, 2021, Online

Objectives:

  • The master class aims to provide graduate, master, PhD and postdoc students with basic and expert knowledge to phenotype morphologically mouse models of human diseases.
  • It's a unique chance to understand the basic principles of several key methods from structural to functional imaging and to get an overview of the best practices including the 3’R rules to design scientific experiments.

Informations:

More information at https://imaging-pathbio.sciencesconf.org/


TRAINING COURSE

In vivo CRISPR-Cas9 genome editing

October 7 - 8, 2021, Strasbourg, France

More information at https://cnrsformation.cnrs.fr/in-vivo-crispr-cas9-genome-editing?mc=CRISPR


TRAINING COURSE

Introduction to mouse embryology: theorical and practical aspects (conducted in French)

November 16 - 17, 2021, Online

Objectives:

  • Acquire a general knowledge of the major stages of the mouse embryonic development
  • Be able to design a first-line phenotyping experiment on mouse embryos
  • Be able to determine a window of lethality in utero
  • Improving knowledge of imaging techniques adapted to mouse embryos

Program: 

Lectures - theoretical aspects (3 hrs)

  • Introduction to the embryonic development of mice: segmentation, gastrulation, the embryonic and foetal periods
  • Development of embryonic lineages

Workshops - practical aspects (3 hrs)

  • Determining the window of lethality of mutant mice in utero
  • Practical aspects of the collection and fixation of mouse embryos and placentas
  • Imaging techniques (HREM, MicroCT, OPT) of embryos

Organisation:

  • Online session - 2 consecutive mornings between Nov. 16th to Nov 17th (whatever the sanitary conditions)
  • The session is conducted in French
  • Registration: online

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/introduction-embryologie-souris?mc=Embryologie%20De


SYMPOSIUM

Club des Belles Souris-colloque 2021

November 18, 2021, Marseille, France

Ces journées ont pour but principal de faciliter les échanges, de promouvoir les contacts et d’aider à la dissémination des connaissances et des compétences sur la génétique de la souris. Elles s’adressent à l’ensemble des personnels s’intéressant aux modèles murins : chercheurs, post-doctorants, étudiants, personnels associés aux plateformes de transgenèse ou d’imagerie et les personnels zootechniques. Pour faciliter ces échanges, les réunions du club des Belles Souris sont informelles et conviviales, en Français et en Anglais, ouvertes à tous et gratuites.

Les orateurs sont d’une part des chercheurs confirmés de renommée internationale et d’autre part de jeunes chercheurs prometteurs. La variété des thématiques abordées dans les présentations favorise les interactions entre scientifiques de domaines de recherche distincts et le développement de nouveaux projets originaux souvent à l’interface entre disciplines différentes.

Colloque 2021

Le prochain Club des Belles Souris aura lieu le 18 novembre 2021 à Marseille. Si la situation sanitaire le permet, le colloque se tiendra selon un format mixte, en personne sur place dans la salle de conférence du GLM CNRS et en ligne. Le nombre de participants sur place est limité et sera ajusté en fonction de la situation de l’épidémie de Covid-19 en novembre. La liste des participants en présentiel sera établie en respectant l’ordre chronologique d’inscription au colloque.

L’inscription est gratuite mais obligatoire en cliquant ici.

Programme prévisionnel

More information at http://stemcells.free.fr/?page_id=1175


TRAINING COURSE

Genotyping: a strategic design rather than a modus operandi (conducted in French)

November 22 - 23, 2021, Strasbourg, France

Genotyping is often considered as a straightforward and easy step; in reality providing robust, accurate, and fast results is frequently more challenging that it seems.

Objectives: 

  • To be able to define a genotyping strategy and understand its interest in the analysis of your model (rodent, zebrafish)
  • Be able to design a genotyping strategy taking into account genetic modification
  • Know how to choose an analysis method according to the allele to be identified
  • Be able to optimise the design of the strategy in terms of primer selection criteria, amplicon size and structure and the development of experimental conditions
  • Be aware of the impact of genotyping error

More information at https://cnrsformation.cnrs.fr/genotypage-design


MEETING

AFSTAL 2021

November 30 - December 2, 2021, Marseille, France

Attend the French congress in animal science

Les Sciences de l’Animal de Laboratoire tous les ans les scientifiques du domaine autour de thèmes scientifiques, règlementaires, éthiques et techniques. Le 46e Colloque annuel de l'association française se déroulera du 30 Novembre au 02 décembre 2021 dans la ville de Marseille et dont le titre sera “Expérimenter c’est aussi anticiper”. En effet, cette année L'AFSTAL traitera le thème de l’anticipation en vue de la réalisation d’un projet dans son ensemble : éthique, expérimental et scientifique et dediera la première session du colloque à la place de l’animal dans les progrès de la recherche pour répondre à une attente sociétale.

PHENOMIN sera présent à cet incontournable rendez vous français en Sciences de l’Animal de Laboratoire. venez nous rejoindre et nous rencontrer !

 

More information at https://www.colloque-afstal.com/2020/


CONGRESS

Flow Cytometry Congress 2021

December 6 - 7, 2021, London, UK

3rd Flow Cytometry Congress

Discover the latest advances in Strategies & Technologies progressing Flow Cytometry and Case Studies in Cellular Analysis.

This year the meeting will focus on new approaches in hydrodynamic and acoustic-assisted focusing, as well as exploring RNA and cytokine analysis techniques. Case studies describe the advances being made in the application of Flow Cytometry in oncology, haematological diseases, and immuno and neuro-inflammation as well as cell sorting.

H. Luche from PHENOMIN-CIPHE will share data aboout flow cytometry and applications.

The meeting is co-located with the 8th qPCR & Digital PCR Congress and the 3rd Liquid Biopsies Congress.

Your delegate pass allows you to track hop across all three meetings.

More information at https://www.global-engage.com/event/flow-cytometry-congress/#speakers-slideshow


SPECIAL EVENT

4th edition of the "Translational Neuroscience Day" 2021

December 10, 2021, Paris, France

Organized by NeurATRIS and CELPHEDIA

This new free edition aims at gathering experts in neurodegenerative diseases with a focus on animal models in Neuroscience Translational Research. Besides, you will be able to interact with all key actors in the field: researchers, clinicians, TTO, biotech, and pharmaceutical companies. This event will also highlight young researcher skills. PHENOMIN will be present to this event.

You could attend in-person as well as online. So, take the opportunity to participate to 3 events in one:

  •  Hear KOLs from Academia and Industry in plenary and round table sessions and young researchers introducing their work in posters and “my thesis in 180 sec”.
  •  Initiate R&D collaborative projects during digital B2B meetings
  •  Increase your network with the virtual poster session

More details on program and registration are coming soon.

SAVE THE DATE !

More information at http://neuratris.com/index.php/fr/calendrier-header/event/163-translational-neuroscience-day-2021


News

Aug. 19, 2021
Conference and abstract submission invitations
July 15, 2021
Save the date for the CCP Conference 2021 !
June 10, 2021
PHENOMIN Newsletter June 2021
June 1, 2021
Understanding the onset of congenital anomalies: useful annotated 3D representations of mouse embryos
April 15, 2021
A resource of targeted mutant mouse lines for 5,061 genes (Nat Genet. 2021)
March 9, 2021
Health and safety of your model colonies: webinar event !
Feb. 25, 2021
A Commitment to Transparency and Openness for Animal Research in France
Feb. 9, 2021
The PHENOMIN- ICS centre is recruiting- Come and join us !
Jan. 18, 2021
Investigation of the role of Macrophages in the integrity and function of the colon epithelium in homeostasis
Dec. 23, 2020
15th Call for proposal - INFRAFRONTIER

Events

September 21 - 23, 2021, Online
Mouse Genetics and Genomic Medicine Conference
September 23, 2021, Online
Virtual MACS® Genomics Day 2021
September 27 - October 5, 2021, Online
3rd Imaging PATHBIO master class
October 7 - 8, 2021, Strasbourg, France
In vivo CRISPR-Cas9 genome editing
November 16 - 17, 2021, Online
Introduction to mouse embryology: theorical and practical aspects (conducted in French)
November 18, 2021, Marseille, France
Club des Belles Souris-colloque 2021
November 22 - 23, 2021, Strasbourg, France
Genotyping: a strategic design rather than a modus operandi (conducted in French)
November 30 - December 2, 2021, Marseille, France
AFSTAL 2021
December 6 - 7, 2021, London, UK
Flow Cytometry Congress 2021
December 10, 2021, Paris, France
4th edition of the "Translational Neuroscience Day" 2021