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Latest News

June 20, 2019 MOUSE GENE ANNOTATION

IMPC's strategy 2021-2030

The International Mouse Phenotyping Consortium’s (IMPC) 10-year strategy presents a bold ambition for the future functional annotation of the genome and deciphering genetic variation in the context of gene function and disease. 2020 will mark the 10th anniversary of the consortium, and then IMPC presents a strategy that encompasses completion of Phase 2, and execution of Phases 3 and 4. PHENOMIN, which has come with other partners to produce this strategy, is really proud of its involvement to this huge project since its inception as a leader from mouse genetics centres across the world.

The 6 key goals of IMPC for 2021–2030 is to deliver broad-based genomic insights into the function of human genetic variation in both coding and non-coding sequences that underpins future developments in precision medicine, rare disease, clinical genetics, and healthy living. This strategy document includes a statement on the underpinning rationale for how mouse genetics and mouse models inform gene function, human disease, and clinical genetics and a clear description fo each key goals.

  • Complete the generation of a null mouse mutant resource for the coding genome
  • Design and produce a genome-wide mouse strain resource of human disease-associated coding variants
  • Design and generate mouse strains that model genetic variation in the non-coding genome
  • Phenotype mouse strains with null mutations, human-disease coding variants, and variants in the non-coding genome to provide a comprehensive catalogue of baseline information on mammalian gene function
  • Explore genetic context to realise the wider potential for mouse functional studies
  • Develop data integration, analysis, and visualisation approaches to translate mouse functional genomics studies to the human gene and disease knowledge base and vice versa

You will find the stategy document on the the new, redesigned website of the IMPC which provides a great user experience !


June 11, 2019 CONGRESS

FELASA 2019, now in progress

FELASA, the Federation of European Laboratory Animal Science Associations, represents over 4000 specialists in the field of laboratory animal science from 28 countries and 21 constituent associations.This triennial congress has grown to become the largest European laboratory animal science event attracting almost 2000 participants. This congress is always organized together with one of the FELASA Constituent Associations, which gives us all a great opportunity to familiarize ourselves with the cultural features of different countries in Europe. This time our host will be CLASA, Czech Laboratory Animal Science Association.

The FELASA Congress is a scientific and educational event, offering the current knowledge on the use and welfare of animals in experiments and how to make improvements in these areas: in Prague, a special issue will be the correct reporting of animal research. Animal welfare, ethical aspects, legislation and education are obvious parts of congress topics. We will also have the newest information and recommendations on how to working with aquatics and some other rarely used species.

FELASA Congress is not only science and education. It is also a large exhibition, showing the recent updates in animal care materials and equipment, animal use and health programs, and research equipment. You will have the opportunity to talk with the representatives from the companies exhibiting, and get information on all new equipment, techniques and almost everything needed when working with laboratory animals.

And finally – professional and social contacts are something invaluable in a face-to-face environment. This is an integral part of the FELASA Congress: meeting colleagues from all over Europe – and beyond – renewing old and making fruitful new acquaintances by means of informal conversations.

The FELASA Congress is the perfect occasion to combine continuing education with informal exchanges of ideas.

A. AYADI, from PHENOMIN-ICS is attending the meeting


June 3, 2019 CALL

Call for proposals - specialized phenotyping

INFRAFRONTIER2020 project - Trans-national Access call for proposals (June 2019)

The INFRAFRONTIER mouse clinics offer the examination of mouse mutants using a broad and standardised phenotypic check-up covering key research areas such as behaviour, clinical chemistry, immunology, energy metabolism, and lung function amongst others. If phenotypes are uncovered by the primary assays, mouse mutants can be subjected to more detailed analyses in hypothesis driven and disease focussed phenotyping pipelines.

In this specialised phenotyping call we provide access to a comprehensive panel of phenotyping tests, relying on standardized and customized protocols in key therapeutic areas. There are 2 proposals:

The second one is proposed by PHENOMIN-CIPHE. Please find below the application form :

Download


May 21, 2019 PATHBIO SCHOOL

Last day to register !

PATHBIO, Precision Pathobiology for Disease Models, is happy to announce the course will be offered from July 15-26, 2019 in Barcelona. The first course on Mouse Embryology, Anatomy, Histology, and anatomical basis of Imaging will take place in the Veterinary School at the Universitat Autònoma de Barcelona (www.uab.cat). The aim is to provide graduate, master, PhD and postdoc students with basic and expert knowledge to phenotype morphologically mouse models of human diseases.

PHENOMIN-ICS is involved in this nice course programme.

There is no fee for this course. Participants have to organize travel and accommodation themselves and cover the corresponding expenses. Interested participants should apply with CV and letter of motivation to Jesús Ruberte (jesus.ruberte@uab.es). Deadline for applications is May 31st, 2019. Accepted participants will be informed middle of June.

Download


May 21, 2019 WEBINAR ANNOUNCE

More parameters, more informative phenotypes: Systematic phenotyping approaches - Sign up for the webinar at May 22nd

Sign up now for the latest Wiley Webinar: Dr. Hervé Luche, PHENOMIN-CIPHE presents new techniques for more parameters, more informative phenotypes: Systematic phenotyping approaches;

with its cutting-edge expertise in mouse genetics and immunology, PHENOMIN-CIPHE aims to develop and analyze, in a massively parallel and standardized mode, mouse KO/KI models, to understand the function of the mouse immune system under normal and infectious conditions. CIPHE has the unique ability to phenotype all the cellular components of the immune system, under normal conditions or confronted with pathogens by, integrating current cutting-edge research and technical knowledge in cytometry.


May 17, 2019 OPEN REGISTRATION

The registration is now open for IMGC 2019 in Strasbourg France, September 25-18, 2019!

The 33rd edition of the annual conference of the International Mammalian Genome Society is held in Strasbourg, France !

We welcome you to the PHENOMIN-ICS and IGBMC ! We are planning an exciting meeting on mammalian genetics and genomics. The perpetual evolution of mammalian genomics is the main focus of IMGS' annual conferences. The meeting will begin with five Workshops followed by a Student Satellite Symposium that offers the opportunity for scientists to compete for awards and presentation slots in the main meeting. Indeed, most of the talks are selected from submitted abstracts and there are poster presentations as well ! The conference will once again include the popular mentoring lunch where those looking for career advice can interact with established scientists.

The window to register is limited -- abstract, registration and IMGS scholarship application deadline is June 16 !

Limited places available, so register early to save your spot !

For more details, please see https://imgc2019.sciencesconf.org/ 

Then, do not hesitate, and register as soons as possible ! We look forward to welcoming you to Strasbourg and the 33rd International Mammalian Genome Conference!<o:p></o:p>


April 11, 2019 ANNOUNCE

PATHBIO - 1st summer school

PATHBIO, Precision Pathobiology for Disease Models, is happy to announce the course will be offered from July 15-26, 2019 in Barcelona. The first course on Mouse Embryology, Anatomy, Histology, and anatomical basis of Imaging will take place in the Veterinary School at the Universitat Autònoma de Barcelona (www.uab.cat). The aim is to provide graduate, master, PhD and postdoc students with basic and expert knowledge to phenotype morphologically mouse models of human diseases.

PHENOMIN-ICS is involved in this nice course programme.

There is no fee for this course. Participants have to organize travel and accommodation themselves and cover the corresponding expenses. Interested participants should apply with CV and letter of motivation to Jesús Ruberte (jesus.ruberte@uab.es). Deadline for applications is May 31st, 2019. Accepted participants will be informed middle of June.

Download


March 28, 2019 INVITATION

ImaGBMC: Imaging Mouse Models

We invite you to be part of the Imaging Mouse Model Workshop !

Wednesday, April 24th 2019, PHENOMIN-iCS and IGBMC organizes a workkshop dedicated to mouse model imaging (Auditorium, IGBMC).The workshop is hosted by Mouse models of human diseases Departement, Nicolas CHARLET BERGUERAND, Gérard GRADWOHL, Yann HERAULT, Philippe KASTNER, Daniel METZGER, Arnaud POTERSZMAN, Bernardo REINA SAN MARTIN

Starting 02:00pm - FREE but mandatory registration

Join us !


March 18, 2019 MOUSE PATHOLOGY

Project PATHBIO is launched in Barcelona

@LluisMontoliu has just tweeted: "Today the Project is launched in Barcelona, led by Jesús Ruberte aiming to teach the future mouse pathologists in Europe. Tomorrow the satellite meeting will be open to the public and I will talk about transparency in laboratory animals research".

PHENOMIN-ICS takes part of the project

 


March 14, 2019 CONFERENCE

INFRAFRONTIER - IMPC conference 2019

Experts in functional mouse genomics will meet with top international medical researchers at the INFRAFRONTIER/IMPC conference 2019 on `Genetic Variation, Big Data and Ageing´.

Registration is now open on , oral and poster presentations may also be offered.

PHENOMIN takes part !



Upcoming events

TRAINING COURSE

WEBINAR Series: Transgenic Mouse and Rat Model Creation

July 1 - January 1, 2019, on line

CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted webinars presented by G. Pavlovic, head of the genetic engineering department of PHENOMIN-ICS

For more information, and to watch the webinar replays on demand, please visit the Charles River Website.

PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.

More information at https://www.criver.com/resources/webinar-series-transgenic-mouse-and-rat-model-creation


CONGRESS

23ème Congrès de l’Association Française de Cytométrie (AFC)

September 17 - 20, 2019, Rennes, France

It is with great pleasure and ambition for the programme that we would like to invite you to the 23rd Congress of the French Association of Cytometry (AFC) from September 18th to 20th 2019, which will take place at the Couvent des Jacobins in the heart of Rennes, a few minutes from the train station.

September 17th will be devoted to practical workshops.

In the spirit of previous editions, the scientific programme will cover the fields of cytometry and imaging applied to hematology, immunology, oncology, microbiology, plant and animal biology and agronomy. The presentation of posters will be encouraged to allow everyone to exchange ideas, and finally a presentation time will be dedicated to industrial partners. To facilitate access for as many people as possible, fees will be targeted to technicians, scholarships and poster prizes will be awarded and the English conferences will be simultaneous translated.

We hope to see many of you in Rennes to celebrate the end of summer 2019.

The Steering Committee

Abstract Submission deadline : 19 mai 2019

PHENOMIN-CIPHE will take part !

More information at https://www.alphavisa.com/afc/2019/


TRAINING COURSE

Cell culture contamination

September 17, 2019, Strasbourg, France

Objectives:

  • Become aware of the importance of traceability and quality control in cell culture
  • Understanding the issue of cell culture contamination
  • Become aware of the diversity of mycoplasma detection methods and be able to choose the techniques adapted to each case
  • Know how to prevent contamination and what attitudes to adopt in the event of proven contamination

The course is conducted in French- Acces to program and registration 

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/stage-19387-Les-contaminations-dans-les-cultures-cellulaires.html?mc=culture-cellulaire


CONGRESS

33rd International Mammalian Genome Conference

September 25 - 29, 2019, Strasbourg, France

The main purpose of the International Mammalian Genome Society is to promote and stimulate research in mammalian genetics from sequencing to functional genomics, mutagenesis and mutant analysis, and to represent the concerns of its members in their professional activities. The company's activities have grown with the growing awareness of the important and unique role of rodent species in biomedical research and current genetics.

The perpetual evolution of mammalian genomics is the main focus of IMGS' annual conferences. The 2 organizers of the 33rd edition are Yann HERAULT (deputy director of the IGBMC, director of PHENOMIN-ICS, Strasbourg and Elected member of the IMGS Secretariat) and Xavier MONTAGUTELLI (head of the Mouse Laboratory, Institut Pasteur, Paris)

The window to register is limited !

Abstract, registration, IMGS and University of Starsbourg scholarship's application deadline is June 23 ! 

Registration discounted for IMGS members. 

For details please see https://imgc2019.sciencesconf.org/

Program:

5 Workshops on Ensembl, GeneWeaver, IMPC, Next Gen Sequencing, and Easi-CRISPR will be on Wednesday, September 25th from 9 - noon. 

The IMGC always includes many opportunities for trainees to present their work and to talk with more senior scientists.  The Trainee Symposium where students and post docs present their work mainly to an audience of their peers will be Wednesday, September 25th from noon to 6 PM.  Three or four of these presentations will be chosen to be presented in the main meeting. 

The main meeting runs from Thursday through Saturday finishing with an awards banquet on Saturday evening. The conference will once again include the popular mentoring lunch where those looking for career advice can interact with established scientists on Thursday, September 26th.

Invited speakers:

  • Rudi Balling will present the Verne Chapman Lecture !
  • Melissa Wilson and Binnaz Yalcin will present Mary Lyon Awardee lectures !
  • Other invited speakers include Marisa Bartolomei, Christine Disteche and Alexandre Reymond !

For questions, please contact:

PHENOMIN-ICS and IGBMC:  emailimgc2019@igbmc.fr

IMGSociety :millerdr@med.unc.edu

 

More information at https://imgc2019.sciencesconf.org/


TRAINING COURSE

In vivo CRISPR-Cas9 genome editing

October 9 - 10, 2019, Strasbourg, France

This training aims to provide a general framework to get scientists started using CRISPR-Cas9 for in vivo gene editing in rodents.

Objectives

  • Learn more about gene editing and how it works
  • Hear about current advances on many technical aspects
  • Optimize the RNA guide design to the genotyping analysis (bioinformatics workshop)
  • Highlight crucial issue in your own scientific project.

Acces to program and registration 

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and birlingm@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/stage-19175-In-vivo-CRISPR-Cas9-genome-editing.html?axe=108


TRAINING COURSE

Mouse embryology: practical training course

October 15 - 17, 2019, Strasbourg, France

Objectives

  • Acquire primary expertise in mouse development
  • Be able to design primary phenotyping experiment on mouse embryos
  • Learn about all the primary phenotyping analysis on mouse embryos
  • Be able to dissect post-implanted embryos
  • Be able to determine the window of lethality in utero
  • Be able to evaluate embryos viability at neonatal stage
  • Increase awareness of relevant technics to image embryos

Acces to detailed program and registration

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)

 

More information at https://cnrsformation.cnrs.fr/stage-19359-Mouse-embryology-practical-training-course.html?mc=embryology

Click here to download the attachment.


TRAINING COURSE

Management of confined environments with biosafety level 3

October 16 - 17, 2019, Meudon, France

Objectives :

  • To know and master the techniques of operating a level 3 containment area (L3/A3)
  • To acquire basic knowledge for managing controls and qualifications on the related installations and critical equipment
  • To know how to avoid contamination
  • To acquire related good practices

The course is conducted in French- Information on program and registration process

CNRS Formation

PHENOMIN's contact: bedu@igbmc.fr and philippe.hoest@inserm.fr (scientific director of the course)

More information at http://www.dgdr.cnrs.fr/SST/CNPS/formations/Doc/ANF%20Pilotage_L3A3_programme2019.pdf


TRAINING COURSE

PATHBIO Imaging mouse master class

November 4 - 8, 2019, Strasbourg, France

PATHBIO Imaging mouse master class consists of one of the three intensive courses from PATHBIO consortium. The PathBio project brings together an ERASMUS+ Knowledge Alliance consortium from across the globe to cooperate on pooling resources and expertise in order to build the framework for a European post graduate degree in Precision pathobiology for disease models.

The Imaging mouse master class will take place from the 4th to the 8th of November, in Strasbourg (from Monday morning to Friday afternoon).

Therorical sessions

  • Animal handling, ethics and regulation
  • Image Analysis (quantitative analysis, visualisation, 3D analysis,..)
  • X-rays and µCT imaging and MRI
  • Echography Heart / other tissue, Opto-acoustic imaging
  • Nuclear Imaging Spect-CT/PET and Bioluminescence
  • Specialized / new imaging, Optical imaging, Embryo (HREM /OPT)

Practical courses:

  • Two half-day sessions will be devoted to hands-on experience and demonstration for trainees

The detailed program is right now in progress and will be defined as soon as possible- HAVE a look to the previous PATHBIO summer school on Anatomy & Pathology

The registration is not yet open: SAVE THE DATE   !

More information at http://pathbio.org/


TRAINING COURSE

Small animal imaging: evolution, potential, limits

November 18 - 22, 2019, Orléans, France

Objectives:

  • Understand potential and limits of different imaging modalities for small animal: biophotonic imaging (bioluminescence, fluorescence 2D and 3D), X rays (X scanner), echography coupled to photoacoustic imaging
  • Be able to select the most suitable approach to address a biological question (phenotyping, functional exploration, biopharmaceutical research...)

The course is conducted in French- Acces to detailed program and registration procedure

CNRS formation entreprises

PHENOMIN's contact: stephanie.lerondel@cnrs-orleans.fr 

More information at https://cnrsformation.cnrs.fr/stage-19193-Imagerie-du-petit-animal--evolution%2C-potentiel%2C-limites.html?mc=imagerie


TRAINING COURSE

Cryopreservation as crucial tool for preserving your murine lines

November 27 - 29, 2019, Orléans, France

Objectives

  • Understanding cryopreservation as an essential tool in a project to create and safeguard a lineage
  • Know how to select the most relevant technique to cryopreserve a line of interest
  • Master embryo and semen freezing techniques
  • Learn how to reduce the number of animals used in animal experiment

The course is conducted in French- Acces to program and registration

CNRS formation entreprises

PHENOMIN's contact: lopes@cnrs-orleans.fr

More information at https://cnrsformation.cnrs.fr/stage-19192-La-cryoconservation--un-outil-pour-la-sauvegarde-des-lignees-murines.html?mc=cryoconservation


News

June 20, 2019
IMPC's strategy 2021-2030
June 11, 2019
FELASA 2019, now in progress
June 3, 2019
Call for proposals - specialized phenotyping
May 21, 2019
Last day to register !
May 21, 2019
More parameters, more informative phenotypes: Systematic phenotyping approaches - Sign up for the webinar at May 22nd
May 17, 2019
The registration is now open for IMGC 2019 in Strasbourg France, September 25-18, 2019!
April 11, 2019
PATHBIO - 1st summer school
March 28, 2019
ImaGBMC: Imaging Mouse Models
March 18, 2019
Project PATHBIO is launched in Barcelona
March 14, 2019
INFRAFRONTIER - IMPC conference 2019

Events

July 1 - January 1, 2019, on line
WEBINAR Series: Transgenic Mouse and Rat Model Creation
September 17 - 20, 2019, Rennes, France
23ème Congrès de l’Association Française de Cytométrie (AFC)
September 17, 2019, Strasbourg, France
Cell culture contamination
September 25 - 29, 2019, Strasbourg, France
33rd International Mammalian Genome Conference
October 9 - 10, 2019, Strasbourg, France
In vivo CRISPR-Cas9 genome editing
October 15 - 17, 2019, Strasbourg, France
Mouse embryology: practical training course
October 16 - 17, 2019, Meudon, France
Management of confined environments with biosafety level 3
November 4 - 8, 2019, Strasbourg, France
PATHBIO Imaging mouse master class
November 18 - 22, 2019, Orléans, France
Small animal imaging: evolution, potential, limits
November 27 - 29, 2019, Orléans, France
Cryopreservation as crucial tool for preserving your murine lines