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Latest News

Jan. 18, 2021 RESEARCH SPOTLIGHT

Investigation of the role of Macrophages in the integrity and function of the colon epithelium in homeostasis

Maintenance of the intestinal barrier is critical given that it controls the absorption of nutrients, electrolytes, and water from the gut lumen into the blood circulation and further prevents the absorption of toxicluminal substances. Macrophages contribute not only to eliminating pathogens but also to the good functioning of most tissues of the human body (management of dead cells, healing, and maintenance of cardiac functions, arterial and neuronal). PHENOMIN-CIPHE has developed an innovative model of knock-in mice which has been used to induce Macrophages depletion (CD64DTR model). The research teams from the Institut Curie (Paris, France) used it to study role of Macrophages in the integrity and function of the colon epithelium in homeostasis. Authors show that sub-epithelial Macrophages perform a rapid quality check of the fluids absorbed through distal colon epithelial cells, protecting them from being poisoned by luminal fungal metabolites.

Chikina A S et al, 2020 –Cell


Dec. 23, 2020 OPEN CALL

15th Call for proposal - INFRAFRONTIER

COVID-19 research with mouse disease models

We are excited to inform you about INFRAFRONTIER´s new free-of-charge TA Call: COVID-19 Therapeutics Pipeline. Our goal is to provide extensive user support to the selected projects for assessing novel potential vaccine and treatment candidates for COVID-19. The TA service is covered by the INFRAFRONTIER2020 project (Horizon 2020). 

INFRAFRONTIER partners (PHENOMIN-CIPHE and CCP) will execute this call by providing viral particles, COVID-19 mouse models, cohort production, and BSL3 pipeline analysis. Further functional analysis and advanced readouts like organ histopathological analysis, multiplex assay profiling of cytokines and chemokines in lung and mouse serum, etc. can be provided on a collaborative basis outside the TA call scope. 

  • Application form: Please fill in the application form and send it to proposals@infrafrontier.eu
  • Application deadline: 31 January 2021
  • Application costs: This TA Call is free-of-charge for the selected applicants.
  • Please contact info@infrafrontier.eu if you have any questions.

For more information about this project and about how to apply please visit our website

For further questions please write to us: proposals@infrafrontier.eu

 


Dec. 17, 2020 ANNOUNCE

Online introduction to Mouse embryology (conducted in French)

PHENOMIN-ICS supports you in acquiring a general knowledge of the major stages of the mouse embryonic development; additionaly O.Wendling and H. Jacobs will train you to be able to design a first-line phenotyping experiment on mouse embryos, to determine a window of lethality in utero and finally to improve your knowledge of imaging techniques adapted to mouse embryos

The training  is scheduled online, next March 30 - 31st, and will be conducted in French.

More information


Oct. 26, 2020 RESOURCES

A customizable poster for your animal welfare body

The AWB is a regulatory structure under the European Directive 2010/63/EU and the French decree 2013-118 (Art. R. 214-103 of the Rural Code), mandatory for each breeder, supplier or user of animals for scientific purposes.
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CELPHEDIA network offers a customizable poster whose aim is to promote the missions of the AWB in France, to bring together local AWBs and their users. The poster can be downloaded in powerpoint format for customizing on request to celphedia@igbmc.fr. It is intended to be displayed in each animal facility to help all staff, especially newcomers, to understand what is the AWB. An update with your own AWB information is recommended for display in locations frequented by all concerned. The poster is available in French and in English, both versions being integrated into the file.

Download


Oct. 7, 2020 ONLINE WEBINAR

Mouse Study Reproducibility: the Impact of Genetic Background and Genotyping

In collaboration with our partner Charles River, Sylvie Jacquot (PHENOMIN-ICS) will present the impact of Genotyping in the mouse study reproducibility throught online webinar scheduled next week, on Thursday, October 15, 2020, 10:00 AM - 11:00 AM EDT (4:00 PM - 5:00 PM CEST)

Many researchers would agree that the extreme complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies.

Join us as we cover the following topics in this presentation:

  • Key factors impacting genetic background and characterization
  • Common inconsistencies/errors in genotyping and employing the latest tools/technology
  • Best practices for establishing rapid and reliable testing protocols

Registration


Sept. 10, 2020 INVITATION

Targeting Cancer with Animal Models - Move online !

 Mark your calendar for our upcoming annual INFRAFRONTIER 2020 Conference, which will focus on Targeting Cancer with Animal Models.

Please note: Due to the COVID-19 pandemic, the conference has been rescheduled to 07 - 08 October and moved online completely. 

Registration Deadline: 2. October! 

Registration: https://www.infrafrontier.eu/meeting-tool/xhtml/infraFrontierEvents.jsf

Event Page:  https://www.infrafrontier.eu/infrafrontier-research-infrastructure/public-relations/infrafrontier-conference-2020


Aug. 25, 2020 OPEN CALL

14th PHENOMIN call : extended submission deadline !

The 14th PHENOMIN call related to creation and phenotyping of mouse rodent line is open. The dead line submission is extended to September 30th.

 


July 16, 2020 ANIMAL MODELS

Animal models in biomedicine

The latest letter from the French academy of science has been published in May 2020 and deals with animal models in research. True to its mission, and with the help of renowned researchers, it didactically conveys known scientific information to answer how scientists have long sought to simplify the study of complex organisms, how to assess the relevance of these models and what ethical framework accompanies the use of laboratory animals when necessary.

From cell cultures, organoids, to rodents, or aquatic vertebrates, or even non-human primates, this letter offers a real overview of the models currently in use and raises the question of their future to meet the challenges of scientific research.

Have a look the complete letter !


July 6, 2020 PHENOMIN CALL

Launch of the 14th PHENOMIN call for proposals !

New PHENOMIN’s Call is open !

We are glad to announce the 14th PHENOMIN call for proposals for innovative mouse and rat model generation and/or phenotyping.

**Extended submission deadline : 30th September 2020**

PHENOMIN is able to support scientists to create and phenotype new models to study:

  • human pathologies or rare diseases
  • cancer research and oncology
  • new genomic variants in the non-coding and coding genome
  • immunity and infection
  • ageing
  • microbiota
  • embryonic development

Since 2011, PHENOMIN has generated 265 models for the International Mouse Phenotyping Consortium (knock-out mice to decipher the coding genome) and more than 900 models for the French and International scientific community.

After this summer, in total up to 25 news models will be selected !

The short and simple submission process and conditions of eligibility can be accessed here.

We are looking forward your submission during this summer ! And do not hesitate to disseminate to whom could be interested by.

Sincerely,

PHENOMIN’s teams (Cécile Frémond, Bernard Malissen and Yann Hérault)


June 23, 2020 ANNOUNCE

Always by your side !

Dear users,

Thanks to the professionalism of our teams and their commitment, PHENOMIN was able to maintain a large panel of mouse lines for your research.The reopening of our activities is now done and you can access again all our services and resources, from the rodent line generation to their phenotyping.

We are looking forward to hear about your projects and requests,

Always by your side,

The PHENOMIN teams!



Upcoming events

TRAINING COURSE

Cell culture contamination (conducted in French)

March 16, 2021, Strasbourg, France

Objectives:

  • Become aware of the importance of traceability and quality control in cell culture
  • Understanding the issue of cell culture contamination
  • Become aware of the diversity of mycoplasma detection methods and be able to choose the techniques adapted to each case
  • Know how to prevent contamination and what attitudes to adopt in the event of proven contamination

The course is conducted in French- Acces to program and registration 

The training will be held online, for 2 consecutive mornings on March 15th and March 16th, if sanitary conditions require it.

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/contaminations-dans-cultures-cellulaires?mc=culture


TRAINING COURSE

Online introduction to Mouse embryology (conducted in French)

March 30 - 31, 2021, online

Introduction to mouse embryology: theorical and practical aspects

Objectives:

  • Acquire a general knowledge of the major stages of the mouse embryonic development
  • Be able to design a first-line phenotyping experiment on mouse embryos
  • Be able to determine a window of lethality in utero
  • Improving knowledge of imaging techniques adapted to mouse embryos

Program: 

Lectures - theoretical aspects (3 hrs)

  • Introduction to the embryonic development of mice: segmentation, gastrulation, the embryonic and foetal periods
  • Development of embryonic lineages

Workshops - practical aspects (3 h)

  • Determining the window of lethality of mutant mice in utero
  • Practical aspects of the collection and fixation of mouse embryos and placentas
  • Imaging techniques (HREM, MicroCT, OPT) of embryos

Organisation:

  • Online session - 2 consecutive mornings between March 30th to March 31st (whatever the sanitary conditions)
  • The session is conducted in French
  • Registration: online

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)

This theoretical training may be supplemented by face-to-face training including practical work in Nov. 2021

More information at https://cnrsformation.cnrs.fr/introduction-embryologie-souris?mc=Embryologie


TRAINING COURSE

WEBINAR Series: Mouse Study Reproducibility

April 4 - October 4, 2021, Online

The complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies. For further insight we are pleased to present the following Charles River-hosted webinar presented by S. Jacquot  from PHENOMIN-ICS

PHENOMIN-ICS covers the following topics in this presentation

  1. Key factors impacting genetic background and characterization
  2. Common inconsistencies/errors in genotyping and employing the latest tools/technology
  3. Best practices for establishing rapid and reliable testing protocols

Genotyping step is crucial in the model creation process as it allows to select animals carrying the good combination of alleles for phenotyping analyses. The different technics are based on the search for a variation in the DNA sequence (in length, composition, quantification...) located at a well-defined place in the genome. PHENOMIN-ICS offers customized genotyping services for knock-out, knock-in, transgenic or any other genetically modified murine model. Different sample types can be processed, including tail biopsies, ear punches, embryonic yolk sac, as well as non-invasive biopsies. We provide a detailed genotyping protocol to all our users on request. 

 How can we help you? Request a quote or email us.

More information at http://www.phenomin.fr/en-us/contact/


TRAINING COURSE

WEBINAR Series: Transgenic Mouse and Rat Model Creation

April 5 - January 5, 2021, Online

CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted and Labroots-hosted webinars presented by G. Pavlovic and M-C Birling from PHENOMIN-ICS

PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.

More information at http://www.phenomin.fr/en-us/contact/


TRAINING COURSE

Cell culture contamination (conducted in French)

June 8, 2021, Strasbourg, France

Objectives:

  • Become aware of the importance of traceability and quality control in cell culture
  • Understanding the issue of cell culture contamination
  • Become aware of the diversity of mycoplasma detection methods and be able to choose the techniques adapted to each case
  • Know how to prevent contamination and what attitudes to adopt in the event of proven contamination

The course is conducted in French- Acces to program and registration 

The training will be held online, for 2 consecutive mornings on June 7th and June 8th, if sanitary conditions require it.

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/contaminations-dans-cultures-cellulaires?mc=Contamination


TRAINING COURSE

In vivo CRISPR-Cas9 genome editing

October 7 - 8, 2021, Strasbourg, France

More information at https://cnrsformation.cnrs.fr/in-vivo-crispr-cas9-genome-editing?mc=CRISPR


TRAINING COURSE

Mouse embryology: practical training course (conducted in French)

November 16 - 18, 2021, Strasbourg, France

Objectives

  • Acquire primary expertise in mouse development
  • Be able to design primary phenotyping experiment on mouse embryos
  • Learn about all the primary phenotyping analysis on mouse embryos
  • Be able to dissect post-implanted embryos
  • Be able to determine the window of lethality in utero
  • Be able to evaluate embryos viability at neonatal stage
  • Increase awareness of relevant technics to image embryos

Organisation:

Acces to detailed program and registration

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/embryologie-souris?axe=141