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Maintenance of the intestinal barrier is critical given that it controls the absorption of nutrients, electrolytes, and water from the gut lumen into the blood circulation and further prevents the absorption of toxicluminal substances. Macrophages contribute not only to eliminating pathogens but also to the good functioning of most tissues of the human body (management of dead cells, healing, and maintenance of cardiac functions, arterial and neuronal). PHENOMIN-CIPHE has developed an innovative model of knock-in mice which has been used to induce Macrophages depletion (CD64DTR model). The research teams from the Institut Curie (Paris, France) used it to study role of Macrophages in the integrity and function of the colon epithelium in homeostasis. Authors show that sub-epithelial Macrophages perform a rapid quality check of the fluids absorbed through distal colon epithelial cells, protecting them from being poisoned by luminal fungal metabolites.
COVID-19 research with mouse disease models
We are excited to inform you about INFRAFRONTIER´s new free-of-charge TA Call: COVID-19 Therapeutics Pipeline. Our goal is to provide extensive user support to the selected projects for assessing novel potential vaccine and treatment candidates for COVID-19. The TA service is covered by the INFRAFRONTIER2020 project (Horizon 2020).
INFRAFRONTIER partners (PHENOMIN-CIPHE and CCP) will execute this call by providing viral particles, COVID-19 mouse models, cohort production, and BSL3 pipeline analysis. Further functional analysis and advanced readouts like organ histopathological analysis, multiplex assay profiling of cytokines and chemokines in lung and mouse serum, etc. can be provided on a collaborative basis outside the TA call scope.
For more information about this project and about how to apply please visit our website
For further questions please write to us: proposals@infrafrontier.eu
PHENOMIN-ICS supports you in acquiring a general knowledge of the major stages of the mouse embryonic development; additionaly O.Wendling and H. Jacobs will train you to be able to design a first-line phenotyping experiment on mouse embryos, to determine a window of lethality in utero and finally to improve your knowledge of imaging techniques adapted to mouse embryos
The training is scheduled online, next March 30 - 31st, and will be conducted in French.
The AWB is a regulatory structure under the European Directive 2010/63/EU and the French decree 2013-118 (Art. R. 214-103 of the Rural Code), mandatory for each breeder, supplier or user of animals for scientific purposes.
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CELPHEDIA network offers a customizable poster whose aim is to promote the missions of the AWB in France, to bring together local AWBs and their users. The poster can be downloaded in powerpoint format for customizing on request to celphedia@igbmc.fr. It is intended to be displayed in each animal facility to help all staff, especially newcomers, to understand what is the AWB. An update with your own AWB information is recommended for display in locations frequented by all concerned. The poster is available in French and in English, both versions being integrated into the file.
In collaboration with our partner Charles River, Sylvie Jacquot (PHENOMIN-ICS) will present the impact of Genotyping in the mouse study reproducibility throught online webinar scheduled next week, on Thursday, October 15, 2020, 10:00 AM - 11:00 AM EDT (4:00 PM - 5:00 PM CEST)
Many researchers would agree that the extreme complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies.
Join us as we cover the following topics in this presentation:
Mark your calendar for our upcoming annual INFRAFRONTIER 2020 Conference, which will focus on Targeting Cancer with Animal Models.
Please note: Due to the COVID-19 pandemic, the conference has been rescheduled to 07 - 08 October and moved online completely.
Registration Deadline: 2. October!
Registration: https://www.infrafrontier.eu/meeting-tool/xhtml/infraFrontierEvents.jsf
The 14th PHENOMIN call related to creation and phenotyping of mouse rodent line is open. The dead line submission is extended to September 30th.
The latest letter from the French academy of science has been published in May 2020 and deals with animal models in research. True to its mission, and with the help of renowned researchers, it didactically conveys known scientific information to answer how scientists have long sought to simplify the study of complex organisms, how to assess the relevance of these models and what ethical framework accompanies the use of laboratory animals when necessary.
From cell cultures, organoids, to rodents, or aquatic vertebrates, or even non-human primates, this letter offers a real overview of the models currently in use and raises the question of their future to meet the challenges of scientific research.
Have a look the complete letter !
New PHENOMIN’s Call is open !
We are glad to announce the 14th PHENOMIN call for proposals for innovative mouse and rat model generation and/or phenotyping.
**Extended submission deadline : 30th September 2020**
PHENOMIN is able to support scientists to create and phenotype new models to study:
Since 2011, PHENOMIN has generated 265 models for the International Mouse Phenotyping Consortium (knock-out mice to decipher the coding genome) and more than 900 models for the French and International scientific community.
After this summer, in total up to 25 news models will be selected !
The short and simple submission process and conditions of eligibility can be accessed here.
We are looking forward your submission during this summer ! And do not hesitate to disseminate to whom could be interested by.
Sincerely,
PHENOMIN’s teams (Cécile Frémond, Bernard Malissen and Yann Hérault)
Dear users,
Thanks to the professionalism of our teams and their commitment, PHENOMIN was able to maintain a large panel of mouse lines for your research.The reopening of our activities is now done and you can access again all our services and resources, from the rodent line generation to their phenotyping.
We are looking forward to hear about your projects and requests,
Always by your side,
The PHENOMIN teams!
Objectives:
The course is conducted in French- Acces to program and registration
The training will be held online, for 2 consecutive mornings on March 15th and March 16th, if sanitary conditions require it.
CNRS formation entreprises
PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)
More information at https://cnrsformation.cnrs.fr/contaminations-dans-cultures-cellulaires?mc=culture
Introduction to mouse embryology: theorical and practical aspects
Objectives:
Program:
Lectures - theoretical aspects (3 hrs)
Workshops - practical aspects (3 h)
Organisation:
PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)
This theoretical training may be supplemented by face-to-face training including practical work in Nov. 2021
More information at https://cnrsformation.cnrs.fr/introduction-embryologie-souris?mc=Embryologie
The complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies. For further insight we are pleased to present the following Charles River-hosted webinar presented by S. Jacquot from PHENOMIN-ICS
PHENOMIN-ICS covers the following topics in this presentation
Genotyping step is crucial in the model creation process as it allows to select animals carrying the good combination of alleles for phenotyping analyses. The different technics are based on the search for a variation in the DNA sequence (in length, composition, quantification...) located at a well-defined place in the genome. PHENOMIN-ICS offers customized genotyping services for knock-out, knock-in, transgenic or any other genetically modified murine model. Different sample types can be processed, including tail biopsies, ear punches, embryonic yolk sac, as well as non-invasive biopsies. We provide a detailed genotyping protocol to all our users on request.
How can we help you? Request a quote or email us.
More information at http://www.phenomin.fr/en-us/contact/
CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted and Labroots-hosted webinars presented by G. Pavlovic and M-C Birling from PHENOMIN-ICS
PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.
More information at http://www.phenomin.fr/en-us/contact/
Objectives:
The course is conducted in French- Acces to program and registration
The training will be held online, for 2 consecutive mornings on June 7th and June 8th, if sanitary conditions require it.
CNRS formation entreprises
PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)
More information at https://cnrsformation.cnrs.fr/contaminations-dans-cultures-cellulaires?mc=Contamination
This training aims to provide a general framework to get scientists started using CRISPR-Cas9 for in vivo gene editing in rodents.
Objectives
Acces to program and registration
The training will be held online, for 3 consecutive mornings, on the same dates, if sanitary conditions require it.
CNRS formation entreprises
PHENOMIN's contact: bedu@igbmc.fr and birlingm@igbmc.fr (scientific director of the course)
More information at https://cnrsformation.cnrs.fr/in-vivo-crispr-cas9-genome-editing?mc=CRISPR
Objectives
Organisation:
Acces to detailed program and registration
CNRS formation entreprises
PHENOMIN's contact: bedu@igbmc.fr and olivia@igbmc.fr (scientific director of the course)
More information at https://cnrsformation.cnrs.fr/embryologie-souris?axe=141