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Epilepsy (seizure disorders) is the 4th most common neurological disorder and affects people of all ages. Seizures are caused by abnormal bursts of neurons firing off electrical impulses and symptoms depend on individuals (from odd feeling to loss of consciousness and convulsions).
Monitoring electrophysiological activity in the brain through multiple electrical leads is very pertinent to seizure disorders.
This test is frequently used for screening of the potential antiepileptic drugs and is based on the excitotoxic properties of pentylene-tetrazol (PTZ). This substance acts as a non-competitive GABA-A receptor antagonist that reduces neuronal inhibition.
Example of results obtained with mutant mice. At the dose of 40 mg/kg IP, PTZ induced myoclonia in all animals and clonic seizures in 80% of mice from the control group. Mutant mice showed decreased susceptibility to PTZ; only 50% of mutant mice shows myoclonic seizures and 25% clonic seizures [W2 = 7.4, p < 0.01 vs WT].
10 mice per group are recommended for reliable data analysis