I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Common blood disorders include anemia, bleeding disorders such as hemophilia, blood clots, and blood cancers such as leukemia, lymphoma, and myeloma.
Tail-vein clotting test in warm saline indirectly examines the volume of blood loss before spontaneous staunching. Proposed first-line analysis for potential clotting disorders with second-line analysis by ex vivo coagulation testing.
The measurement of various blood metabolites, ions, and enzymes provides a primary screen for function of major metabolic organs such as kidney, liver, gastrointestinal tract, as well as for lipid and glucose homeostasis.
A panel of parameters is proposed, including:
Selected plasma chemistry data from female mice (N=20 per line) of common laboratory strains at different ages (Champy et al. Mammalian Genome 2008). Error bars reflect ± SEM.
These tests are performed with an AU-480 automated laboratory work station (Beckman Coulter France SAS, Villepinte, France).
Champy MF, Selloum M, Zeitler V, Caradec C, Jung B, Rousseau S, Pouilly L, Sorg T, Auwerx J. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome. 2008 May;19(5):318-31. Epub 2008 Apr 5.
Determination of prothrombine time, activated partial thromboplastin time and fibrinogen activity.
ST4 semi automated coagulometer (Diagnostiqua Stago, Gennevilliers, France).
It is recommended to collect blood by intra-cardiac puncture.
First-line hematological/immunological analysis of blood or tissue infiltrates for different leukocyte lineages. May be targeted to examine particular immune lineage subclasses.
Please see our Immunology dedicated page for more detailed tests.
FACS analysis are performed on a LSR II (BD diagnostics, Le pont de Claix, France).
See our Gene expression analysis dedicated page to explore our different related tests.