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This new free edition on December 10, 2021 aims at gathering experts in neurodegenerative diseases with a focus on animal models in Neuroscience Translational Research. Besides, you will be able to interact with all key actors in the field: researchers, clinicians, TTO, biotech, and pharmaceutical companies. This event will also highlight young researcher skills.
Online registration is free and mandatory before November 30th.
This year, in-person sessions in Paris will be combined with online sessions meaning you can also join “Translational Neuroscience Day” from your office as well.
The event is supported by EATRIS (The European Infrastructure for Translational Medicine), and especially NeurATRIS ( Innovations for transnational neurosciences) And CELPHEDIA (The French infrastructure in Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms)
This 100 % online event gives the opportunity for each ab/team - on one place, on one day - to present its research and meet numerous companies based around the world in order to discover new materials, equipment, research processes etc. and to develop collaborations.
Join B. Petit Demoulière, from PHENOMIN-ICS, into our virtual Booth # F33 (Academic laboratories & Platforms series) - and live special interaction experience to understand more how we support Neurosciences research !
The forum will be held fully online on Virbela, a platform recreating a congress hall where each participant is present in the form of an avatar. Companies and Neurex labs have the possibility to display pictures and slides on booths dedicated to their organisation. The platform offers an ideal communication support and real-life type of interactions between participants: free moving around, discussion in private mode...
We hope to meet you there !
The ‘Mouse Genetics and Genomic Medicine’ is a virtual conference organised by the International Mouse Phenotyping Consortium – IMPC (https://www.mousephenotype.org) to celebrate the occasion of the 10th anniversary of the establishment of the IMPC.
PHENOMIN is part and invite you to join us !
For more information, please visit the IMPC Virtual Conference Website
It is my great pleasure to invite you to the third CCP Phenogenomics Conference. This year, the conference will be a virtual meeting due to the continuing uncertainty about travel.
The scientific committee has selected two main thematic focuses.
Even though, taking place only in a virtual environment, we believe that the Conference will provide an excellent opportunity to support networking and interactions among the CCP users and experts.
We are looking forward to meeting you virtually in September 2021.
Director of the Czech Centre for Phenogenomics
Institute of Molecular Genetics of the Czech Academy of Sciences"
We invite you to browse through our latest newsletter, whose main topics are
Congenital anomalies (CA) affect 1 in 33 infants worldwide and result in approximately 3.1 million birth defect-related disabilities every year. CA are generally diagnosed only after birth or, more rarely, at late stages of pregnancy. Yet, most of them are determined early during the very first weeks after fertilization. To better understand the pathogenesis of CA at early embryonic stages, researchers from IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) and PHENOMIN-ICS (PHENOMIN-Institut Clinique de la Souris) proposed to compare three-dimensional (3D) reconstructions of mouse embryos carrying known mutations with their normal littermates at the start of appearance of the different organs. They are first aiming to compare mouse embryos at embryonic day 11.5 (E11.5) which are very similar to human embryos at the 6th week of gestation.
3D imaging is a useful tool to characterize morphological phenotypes, but also to describe the normal anatomy of embryos for educational purposes. Therefore, as a start, the researchers provide to the scientific community the first annotated 3D representation of E11.5 mouse embryo using HREM (high resolution episcopic microscopy). This technology generates images that are comparable to histology in terms of resolution: it allows visualizing the surfaces and volumes of internal organs and cavities, in the nervous system, heart and vasculature, primitive gut, and urogenital system. Each image content is detailed and annotated, inspired by the texts of Karl Theiler (1972) and Matthew Kaufman (1992).
This innovative educational material was developed as part of our participation in the PATHBIO consortium, which aims at designing and developing a series of innovative materials destined for teaching the anatomy, histology, embryology, imaging and pathology of the mouse. We are pleased that it is now freely available online.
And congratulations to the teams!
 Karl Theiler, The House Mouse © Springer 1972
 Matthew H. Kaufman, The Atlas of Mouse Development © Academic Press 1992
This April, an article in Nature Genetics highlights the major contribution of PHENOMIN-ICS in the International Mouse Phenotyping Consortium (IMPC) for the implementation of a comprehensive quality control strategy for alleles in targeted embryonic stem cell clones produced by high throughput. More than 5000 resulting mouse lines were generated with these ES cell clone through a collaborative effort of the different IMPC centers. All of them have the great advantage of having been established in the same C57BL/6N genetic background. Almost 3,700 have a versatile allele that has the advantage of being able to be transformed either into a conditional knockout or into a knockout bearing a LacZ reporter gene. The conditional allele remains a tool of choice for all scientists wishing to perform more detailed analyzes. The total number of genes with a potential conditional allele has been nearly doubled thanks to the effort of the IMPC.
The ultimate goal of IMPC is to generate and phenotype in a standardized manner the KOs of all protein-coding genes to provide key information for the biology and understanding of the development of human diseases. We were able to show that 72% of the KO lines show at least one phenotype, thus revealing a significant pleiotropy. This proportion includes the 39 % showing partial or total lethality. Thanks to this tremendous effort, almost half of the genome is now targeted. Since 2015, the production of KOs from ES cells has been replaced by simple KOs obtained by CRISPR / Cas9 technology. However, in the new era of genome editing, this ES cell-derived collection remains of unique value, as it offers particularly sophisticated and quality-controlled alleles representing a cornerstone of the collective development of a resource of null allele for the complete genome of mammals.
Do you want to take advantage of our expertise to manage the health and safety of your favorite models and to improve data reproducibility ? Take the “fast track” towards protecting the health and safety of your model colonies with the Charles River's upcoming “Quick Insights in Animal Health” event in which PHENOMIN-ICS will share crucial information through the various presentations of track 3 and 6. The free learning series features short, on-demand presentations (each no more than 15 minutes) across six different tracks.
See you online, March 29th !
The French interprofessional research think tank Gircor has just published a Transparency Charter on the use of animals for scientific and regulatory purposes signed by several entities of the scientific community in France, including PHENOMIN.
PHENOMIN is committed to ensuring better transparency by informing on current research and by giving the opportunity to understand the place of the animal models in scientific and biomedical research's progresses, and finally by explaining the conditions under which animal research is practiced.
The French initiative will strengthen the overall vision shared with many European countries and many scientists to support transparency for animal research.
IGBMC, one of Europe's leading biomedical research centers counting 700 employees of 45 nationalities and 47 research teams focusing on the study of human pathologies such as cancer and genetic diseases. The Mouse Clinical Institute (Institut Clinique de la Souris - iCS), the IGBMC's largest technology platform, is ISO 9001 and NFX 50-900 certified. It is the leading center of the national infrastructures PHENOMIN and CELPHEDIA and a key player in the European and global effort to annotate the mouse genome via the INFRAFRONTIER and IMPC consortia.
The IGBMC campus is located on the Illkirch Innovation Park in the suburbs of Strasbourg, France, an exceptional academic and industrial scientific environment that strongly favors collaborations and technology transfer.
For its activities the iCS relies on its IT Development Manager (M/F).
A permanent position to be filled as soon as possible
Discover the latest advances in Strategies & Technologies progressing Flow Cytometry and Case Studies in Cellular Analysis.
This year the meeting will focus on new approaches in hydrodynamic and acoustic-assisted focusing, as well as exploring RNA and cytokine analysis techniques. Case studies describe the advances being made in the application of Flow Cytometry in oncology, haematological diseases, and immuno and neuro-inflammation as well as cell sorting.
H. Luche from PHENOMIN-CIPHE will share data aboout flow cytometry and applications.
Your delegate pass allows you to track hop across all three meetings.
More information at https://www.global-engage.com/event/flow-cytometry-congress/#speakers-slideshow
8th qPCR & Digital PCR Congress- EXPLORING ADVANCES IN TECHNOLOGY AND RESEARCH WITH QPCR, DPCR
The 2021 meeting will focus on the challengs in using powerful qPCR tool. inded it enables the detection of rare point mutations and mutations induced by gene editing in a background of wild-type sequences. However, in a clinical setting, users have to pay a crucial attention to the accuracy, reproducibility, assay optimisation, multiplexing, standardisation and translating methods into applications. Over the meeting, case studies and interactive sessions will explore qPCR & DPCR across diverse areas such as oncology, infectious diseases, vaccines, clinical applications, microbiology, and other novel applications. The meeting is collocated with the 3rd Flow Cytometry Congress and the 3rd Liquid Biopsies Congress. Attendees can track hop across all three events.
G. Pavlovic, from PHENOMIN-ICS will share some of our data using ddPCR in mice by presenting "Evaluation of the reliability of the digital droplet PCR and RT-ddPCR on a large number of samples and targets" - Tuesday Dec. 7th
H Luche, from PHENOMIN-CIPHE will present "Immuno-Profiling of Murine preclinical Tumor Models in the Cytomic area: A way to improve Translational Prediction for Immune-Based Therapeutics" - Monday Dec.6th as part of the 3rd Flow Cytometry Congress
More information at http://www.global-engage.com/event/qpcr-and-digital-pcr/
This new free edition aims at gathering experts in neurodegenerative diseases with a focus on animal models in Neuroscience Translational Research. Besides, you will be able to interact with all key actors in the field: researchers, clinicians, TTO, biotech, and pharmaceutical companies. This event will also highlight young researcher skills. PHENOMIN will be present to this event.
You could attend in-person as well as online. So, take the opportunity to participate to 3 events in one:
CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted and Labroots-hosted webinars presented by G. Pavlovic and M-C Birling from PHENOMIN-ICS
PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.
More information at http://www.phenomin.fr/en-us/contact/
The complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies. For further insight we are pleased to present the following Charles River-hosted webinar presented by S. Jacquot from PHENOMIN-ICS and J. Cozzi from Charles River
PHENOMIN-ICS covers the following topics in this presentation
This webinar highlights how genotyping is a crucial step in the successful generation of your models. PHENOMIN-ICS offers customized genotyping services for knock-out, knock-in, transgenic or any other genetically modified murine model. Different sample types can be processed, including tail biopsies, ear punches, embryonic yolk sac, as well as non-invasive biopsies.
More information at http://www.phenomin.fr/en-us/contact/
CNRS formation entreprises
Conducted in French !
Genotyping is often considered as a straightforward and easy step; in reality providing robust, accurate, and fast results is frequently more challenging that it seems.
CNRS formation entreprises
More information at https://cnrsformation.cnrs.fr/genotypage-design
This training aims to provide a general framework to get scientists started using CRISPR-Cas9 for in vivo gene editing in rodents.
CNRS formation entreprises
More information at https://cnrsformation.cnrs.fr/in-vivo-crispr-cas9-genome-editing?mc=CRISPR