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Latest News

Oct. 28, 2021 OPPORTUNITIES

2 last day to free registration !

Animal models in Neuroscience Translational Research

This new free edition on December 10, 2021 aims at gathering experts in neurodegenerative diseases with a focus on animal models in Neuroscience Translational Research. Besides, you will be able to interact with all key actors in the field: researchers, clinicians, TTO, biotech, and pharmaceutical companies. This event will also highlight young researcher skills.

Online registration is free and mandatory before November 30th.

This year, in-person sessions in Paris will be combined with online sessions meaning you can also join “Translational Neuroscience Day” from your office as well.

The event is supported by EATRIS (The European Infrastructure for Translational Medicine), and especially NeurATRIS ( Innovations for transnational neurosciences) And CELPHEDIA (The French infrastructure in Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms)


Oct. 12, 2021 MEET AND JOIN US !

Join PHENOMIN-ICS to the Neurex NeuroForum

The Neurex NeuroForum 2021 and the Opportunities to interact with industry companies

This 100 % online event gives the opportunity for each ab/team - on one place, on one day - to present its research and meet numerous companies based around the world in order to discover new materials, equipment, research processes etc. and to develop collaborations.

Join B. Petit Demoulière, from PHENOMIN-ICS, into our virtual Booth # F33 (Academic laboratories & Platforms series) - and live special interaction experience to understand more how we support Neurosciences research !

The forum will be held fully online on Virbela, a platform recreating a congress hall where each participant is present in the form of an avatar. Companies and Neurex labs have the possibility to display pictures and slides on booths dedicated to their organisation. The platform offers an ideal communication support and real-life type of interactions between participants: free moving around, discussion in private mode...

Program

  • 09.00 – 11.00 am (Paris) NeuroForum - Exhibition hall
  • 11.00 – 12.45 am (Paris) Conference « Patent & Intelectual property »
  • 12.45 – 02.00 pm  (Paris) NeuroForum - Exhibition hall

We hope to meet you there !


Aug. 19, 2021 INVITATION

Conference and abstract submission invitations

The ‘Mouse Genetics and Genomic Medicine’ is a virtual conference organised by the International Mouse Phenotyping Consortium – IMPC (https://www.mousephenotype.org) to celebrate the occasion of the 10th anniversary of the establishment of the IMPC.

PHENOMIN is part and invite you to join us !

  • The conference is hosted virtually on 23-24 September 2021
  • Registration is FREE for all participants.Registration online; Registrants will be receiving the CONFERENCE WEBCAST LINK 3 days before the beginning of the Virtual Conference along with the unique passcode to log on to the Digital conference webcast platform.
  • ABSTRACT SUBMISSION INVITATION :The Organizing Committee invites the submission of abstracts for poster presentation at the International Conference ”Mouse Genetics and Genomic Medicine” on 23 and 24 September 2021. Corresponding authors must fill out the contact form and follow the guidelines. Abstracts not following these Guidelines will not be considered as valid.Submission deadline of Abstracts is Friday, 10 September 2021.
  • Scientific program :Distinguished scientists from all over the world will participate as guest speakers according to the Scientific Program


For more information, please visit the IMPC Virtual Conference Website


July 15, 2021 INVITATION

Save the date for the CCP Conference 2021 !

"Dear Colleagues,

It is my great pleasure to invite you to the third CCP Phenogenomics Conference. This year, the conference will be a virtual meeting due to the continuing uncertainty about travel.

The scientific committee has selected two main thematic focuses.

  • The first day will be dedicated to immunology, infectious diseases, and human diseases models. Among other interesting topics, this day will of course cover Covid-19 related research and the translation of basic research results into application.
  • The second day is specifically dedicated to preclinical development and advances in neuroscience.

Even though, taking place only in a virtual environment, we believe that the Conference will provide an excellent opportunity to support networking and interactions among the CCP users and experts.

We are looking forward to meeting you virtually in September 2021.

Yours sincerely,

Radislav Sedlacek
Director of the Czech Centre for Phenogenomics
Institute of Molecular Genetics of the Czech Academy of Sciences"


June 10, 2021 LATEST NEWS

PHENOMIN Newsletter June 2021

We invite you to browse through our latest newsletter, whose main topics are

  • LATEST NEWS from PHENOMIN 2021
  • DESIGN AND DATA ANALYSIS: OUR VISION
  • OUR last RESEARCH SPOTLIGHT
  • OUR RESOURCES and NETWORKS, great support for your research !
  • UPCOMING EVENTS & TRAININGS....including the Special one for the 10th anniversary of PHENOMIN !

Have a look !

 


June 1, 2021 NEWS

Understanding the onset of congenital anomalies: useful annotated 3D representations of mouse embryos

Congenital anomalies (CA) affect 1 in 33 infants worldwide and result in approximately 3.1 million birth defect-related disabilities every year. CA are generally diagnosed only after birth or, more rarely, at late stages of pregnancy. Yet, most of them are determined early during the very first weeks after fertilization. To better understand the pathogenesis of CA at early embryonic stages, researchers from IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) and PHENOMIN-ICS (PHENOMIN-Institut Clinique de la Souris) proposed to compare three-dimensional (3D) reconstructions of mouse embryos carrying known mutations with their normal littermates at the start of appearance of the different organs. They are first aiming to compare mouse embryos at embryonic day 11.5 (E11.5) which are very similar to human embryos at the 6th week of gestation.

3D imaging is a useful tool to characterize morphological phenotypes, but also to describe the normal anatomy of embryos for educational purposes. Therefore, as a start, the researchers provide to the scientific community the first annotated 3D representation of E11.5 mouse embryo using HREM (high resolution episcopic microscopy). This technology generates images that are comparable to histology in terms of resolution: it allows visualizing the surfaces and volumes of internal organs and cavities, in the nervous system, heart and vasculature, primitive gut, and urogenital system. Each image content is detailed and annotated, inspired by the texts of Karl Theiler[1] (1972) and Matthew Kaufman[2] (1992).

This innovative educational material was developed as part of our participation in the PATHBIO consortium, which aims at designing and developing a series of innovative materials destined for teaching the anatomy, histology, embryology, imaging and pathology of the mouse. We are pleased that it is now freely available online.

And congratulations to the teams!

 

[1] Karl Theiler, The House Mouse © Springer 1972

[2] Matthew H. Kaufman, The Atlas of Mouse Development © Academic Press 1992

 


April 15, 2021 RESEARCH SPOTLIGHT

A resource of targeted mutant mouse lines for 5,061 genes (Nat Genet. 2021)

This April, an article in Nature Genetics highlights the major contribution of PHENOMIN-ICS in the International Mouse Phenotyping Consortium (IMPC) for the implementation of a comprehensive quality control strategy for alleles in targeted embryonic stem cell clones produced by high throughput. More than 5000 resulting mouse lines were generated with these ES cell clone through a collaborative effort of the different IMPC centers. All of them have the great advantage of having been established in the same C57BL/6N genetic background. Almost 3,700 have a versatile allele that has the advantage of being able to be transformed either into a conditional knockout or into a knockout bearing a LacZ reporter gene. The conditional allele remains a tool of choice for all scientists wishing to perform more detailed analyzes. The total number of genes with a potential conditional allele has been nearly doubled thanks to the effort of the IMPC.

The ultimate goal of IMPC is to generate and phenotype in a standardized manner the KOs of all protein-coding genes to provide key information for the biology and understanding of the development of human diseases. We were able to show that 72% of the KO lines show at least one phenotype, thus revealing a significant pleiotropy. This proportion includes the 39 % showing partial or total lethality. Thanks to this tremendous effort, almost half of the genome is now targeted. Since 2015, the production of KOs from ES cells has been replaced by simple KOs obtained by CRISPR / Cas9 technology. However, in the new era of genome editing, this ES cell-derived collection remains of unique value, as it offers particularly sophisticated and quality-controlled alleles representing a cornerstone of the collective development of a resource of null allele for the complete genome of mammals.

Marie- Christine Birling et al., 2021 - Nat Genet.

 

 

 


March 9, 2021 FREE LEARNING EVENTS

Health and safety of your model colonies: webinar event !

Do you want to take advantage of our expertise to manage the health and safety of your favorite models and to improve data reproducibility ?  Take the “fast track” towards protecting the health and safety of your model colonies with the Charles River's upcoming “Quick Insights in Animal Health” event in which PHENOMIN-ICS will share crucial information through the various presentations of track  3 and 6. The free learning series features short, on-demand presentations (each no more than 15 minutes) across six different tracks.

See you online, March 29th !

 


Feb. 25, 2021 NEWS

A Commitment to Transparency and Openness for Animal Research in France

The French interprofessional research think tank Gircor has just published a Transparency Charter on the use of animals for scientific and regulatory purposes signed by several entities of the scientific community in France, including PHENOMIN.

PHENOMIN is committed to ensuring better transparency by informing on current research and by giving the opportunity to understand the place of the animal models in scientific and biomedical research's progresses, and finally by explaining the conditions under which animal research is practiced.

The French initiative will strengthen the overall vision shared with many European countries and many scientists to support transparency for animal research.

Download


Feb. 9, 2021 JOB OPPORTUNITY

The PHENOMIN- ICS centre is recruiting- Come and join us !

IT Development Manager M/F - CDI

Reference: IGBMC / IT-16

IGBMC, one of Europe's leading biomedical research centers counting 700 employees of 45 nationalities and 47 research teams focusing on the study of human pathologies such as cancer and genetic diseases. The Mouse Clinical Institute (Institut Clinique de la Souris - iCS), the IGBMC's largest technology platform, is ISO 9001 and NFX 50-900 certified. It is the leading center of the national infrastructures PHENOMIN and CELPHEDIA and a key player in the European and global effort to annotate the mouse genome via the INFRAFRONTIER and IMPC consortia.

The IGBMC campus is located on the Illkirch Innovation Park in the suburbs of Strasbourg, France, an exceptional academic and industrial scientific environment that strongly favors collaborations and technology transfer.

For its activities the iCS relies on its IT Development Manager (M/F).

A permanent position to be filled as soon as possible

See the offer

Download



Upcoming events

CONGRESS

Flow Cytometry Congress 2021

December 6 - 7, 2021, London, UK

3rd Flow Cytometry Congress

Discover the latest advances in Strategies & Technologies progressing Flow Cytometry and Case Studies in Cellular Analysis.

This year the meeting will focus on new approaches in hydrodynamic and acoustic-assisted focusing, as well as exploring RNA and cytokine analysis techniques. Case studies describe the advances being made in the application of Flow Cytometry in oncology, haematological diseases, and immuno and neuro-inflammation as well as cell sorting.

H. Luche from PHENOMIN-CIPHE will share data aboout flow cytometry and applications.

The meeting is co-located with the 8th qPCR & Digital PCR Congress and the 3rd Liquid Biopsies Congress.

Your delegate pass allows you to track hop across all three meetings.

More information at https://www.global-engage.com/event/flow-cytometry-congress/#speakers-slideshow


CONGRESS

qPCR & Digital PCR Congress 2021

December 6 - 7, 2021, London, UK

8th qPCR & Digital PCR Congress- EXPLORING ADVANCES IN TECHNOLOGY AND RESEARCH WITH QPCR, DPCR

The 2021 meeting will focus on the challengs in using powerful qPCR tool. inded it enables the detection of rare point mutations and mutations induced by gene editing in a background of wild-type sequences. However, in a clinical setting, users have to pay a crucial attention to the accuracy, reproducibility, assay optimisation, multiplexing, standardisation and translating methods into applications. Over the meeting, case studies and interactive sessions will explore qPCR & DPCR across diverse areas such as oncology, infectious diseases, vaccines, clinical applications, microbiology, and other novel applications. The meeting is collocated with the 3rd Flow Cytometry Congress and the 3rd Liquid Biopsies Congress. Attendees can track hop across all three events.

PHENOMIN will be part !

G. Pavlovic, from PHENOMIN-ICS will share some of our data using ddPCR in mice by presenting "Evaluation of the reliability of the digital droplet PCR and RT-ddPCR on a large number of samples and targets" -  Tuesday Dec. 7th

H Luche, from PHENOMIN-CIPHE will present "Immuno-Profiling of Murine preclinical Tumor Models in the Cytomic area: A way to improve Translational Prediction for Immune-Based Therapeutics" -  Monday Dec.6th as part of the 3rd Flow Cytometry Congress

Please have a look to the global agenda

More information at http://www.global-engage.com/event/qpcr-and-digital-pcr/


SPECIAL EVENT

4th edition of the "Translational Neuroscience Day" 2021

December 10, 2021, Paris, France

Organized by NeurATRIS and CELPHEDIA

This new free edition aims at gathering experts in neurodegenerative diseases with a focus on animal models in Neuroscience Translational Research. Besides, you will be able to interact with all key actors in the field: researchers, clinicians, TTO, biotech, and pharmaceutical companies. This event will also highlight young researcher skills. PHENOMIN will be present to this event.

You could attend in-person as well as online. So, take the opportunity to participate to 3 events in one:

  •  Hear KOLs from Academia and Industry in plenary and round table sessions and young researchers introducing their work in posters and “my thesis in 180 sec”.
  •  Initiate R&D collaborative projects during digital B2B meetings
  •  Increase your network with the virtual poster session

Online registration is free and mandatory before November 30th

More information at http://neuratris.com/index.php/fr/calendrier-header/event/163-translational-neuroscience-day-2021


TRAINING COURSE

WEBINAR Series: Transgenic Mouse and Rat Model Creation

December 12 - January 5, 2021, Online

CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted and Labroots-hosted webinars presented by G. Pavlovic and M-C Birling from PHENOMIN-ICS

PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.

More information at http://www.phenomin.fr/en-us/contact/


TRAINING COURSE

WEBINAR Series: Mouse Study Reproducibility

December 12, 2021, Online

The complexity of biological systems we study are a key factor impacting research reproducibility. For studies employing transgenic rodent lines, a lack of understanding of genetic backgrounds, as well as genetic drift, genetic contamination, and genotyping inconsistencies, all contribute to the issue of reproducibility in mouse studies. For further insight we are pleased to present the following Charles River-hosted webinar presented by S. Jacquot  from PHENOMIN-ICS and J. Cozzi from Charles River

PHENOMIN-ICS covers the following topics in this presentation

  1. Key factors impacting genetic background and characterization
  2. Common inconsistencies/errors in genotyping and employing the latest tools/technology
  3. Best practices for establishing rapid and reliable testing protocols

This webinar highlights how genotyping is a crucial step in the successful generation of your models. PHENOMIN-ICS offers customized genotyping services for knock-out, knock-in, transgenic or any other genetically modified murine model. Different sample types can be processed, including tail biopsies, ear punches, embryonic yolk sac, as well as non-invasive biopsies.

How can we help you? Request a quote or email us.

More information at http://www.phenomin.fr/en-us/contact/


TRAINING COURSE

To prevent contamination in cell culture (conducted in French)

March 8, 2022, Strasbourg, France

Objectives:

  • Become aware of the importance of traceability and quality control in cell culture
  • Understanding the issue of cell culture contamination
  • Become aware of the diversity of mycoplasma detection methods and be able to choose the techniques adapted to each case
  • Know how to prevent contamination and what attitudes to adopt in the event of proven contamination

Organisation:

  • The course is conducted in French
  • Acces to program and registration 
  • The training will be held online, for 2 consecutive mornings on March 7th and March 8th, if sanitary conditions require it.

CNRS formation entreprises

PHENOMIN's contact: bedu@igbmc.fr and wattenho@igbmc.fr (scientific director of the course)

More information at https://cnrsformation.cnrs.fr/contaminations-dans-cultures-cellulaires?mc=Contamination


TRAINING COURSE

Genotyping: a strategic design rather than a modus operandi (conducted in French)

April 4 - 5, 2022, Strasbourg, France

Conducted in French !

Genotyping is often considered as a straightforward and easy step; in reality providing robust, accurate, and fast results is frequently more challenging that it seems.

Objectives: 

  • To be able to define a genotyping strategy and understand its interest in the analysis of your model (rodent, zebrafish)
  • Be able to design a genotyping strategy taking into account genetic modification
  • Know how to choose an analysis method according to the allele to be identified
  • Be able to optimise the design of the strategy in terms of primer selection criteria, amplicon size and structure and the development of experimental conditions
  • Be aware of the impact of genotyping error

More information at https://cnrsformation.cnrs.fr/genotypage-design


TRAINING COURSE

In vivo CRISPR-Cas9 genome editing

October 6 - 7, 2022, Strasbourg, France

More information at https://cnrsformation.cnrs.fr/in-vivo-crispr-cas9-genome-editing?mc=CRISPR