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The latest letter from the French academy of science has been published in May 2020 and deals with animal models in research. True to its mission, and with the help of renowned researchers, it didactically conveys known scientific information to answer how scientists have long sought to simplify the study of complex organisms, how to assess the relevance of these models and what ethical framework accompanies the use of laboratory animals when necessary.
From cell cultures, organoids, to rodents, or aquatic vertebrates, or even non-human primates, this letter offers a real overview of the models currently in use and raises the question of their future to meet the challenges of scientific research.
New PHENOMIN’s Call is open !
We are glad to announce the 14th PHENOMIN call for proposals for innovative mouse and rat model generation and/or phenotyping.
**Submission deadline is 31st August 2020**
Since 2011, PHENOMIN has generated 265 models for the International Mouse Phenotyping Consortium (knock-out mice to decipher the coding genome) and more than 900 models for the French and International scientific community.
After this summer, in total up to 25 news models will be selected !
The short and simple submission process and conditions of eligibility can be accessed here.
We are looking forward your submission during this summer ! And do not hesitate to disseminate to whom could be interested by.
PHENOMIN’s teams (Cécile Frémond, Bernard Malissen and Yann Hérault)
Thanks to the professionalism of our teams and their commitment, PHENOMIN was able to maintain a large panel of mouse lines for your research.The reopening of our activities is now done and you can access again all our services and resources, from the rodent line generation to their phenotyping.
We are looking forward to hear about your projects and requests,
Always by your side,
The PHENOMIN teams!
The laboratory mouse is an important preclinical model for studying coronavirus biology and treatment approaches.
The MGI knowledgebase of mouse models of human disease, has collected expertly curated information on mouse models and publications related to coronavirus research. This special collection will be updated regularly.
You will find several tables which summarize information about strains and genes relevant to the study of coronavirus in mouse. This information was obtained from the Mouse Genome Informatics (MGI) knowledgebase hosted at The Jackson Laboratory and from the International Mouse Strain Resource (IMSR).
Thanks to the expertise of our 3 centers, which have been part of the European Infra Border/EMMA infrastructure since 1996, PHENOMIN can help you to save your precious mouse and rat models if they are not already preserved in a reference center. All the expertise acquired over nearly 25 years will be used to define the best solution to preserve your model of interest. If necessary, we can call upon the resources of other French centers belonging to CELPHEDIA Infrastructure. If you are interested, please send your requests to email@example.com.
INFRAFRONTIER and COVID-19 Research
The coronavirus (COVID-19) pandemic is not only a serious threat to global public health, it also deeply affects the social and economic life worldwide. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving and distribution of model mammalian genomes, is fully committed to support researchers around the globe to develop a vaccine against SARS-CoV-2 and to find treatments for COVID-19.
Emergency Archiving During COVID-19 Crisis
Due to the current coronavirus (COVID-19) situation, there is a need to archive various valuable mouse models. Traffic restrictions and other severe measures to slow the spread of the pandemic are in force, but some EMMA nodes are still active and may archive valuable strains.
Please directly contact your closest EMMA node from the list below for archiving possibilities. In contrast to the standard EMMA archiving service, which includes evaluation by an external scientific committee and is free of charge for depositors, the emergency service may come with service charges. Details will be provided by the EMMA nodes.
As the situation in the different countries is changing constantly, we can not give any guarantees. Whether mice can be imported also strongly depends on whether carrier companies are still servicing the respective route from the depositor institute to the EMMA node.
Further details on https://www.infrafrontier.eu/knowledgebase/therapeutic-area/covid-19-resources-and-measures
Dear colleagues, Dear users,
facing the Covid-19 pandemic evolution, we have put in place a business continuity plan (BCP), following a diagnosis that was conducted on March 16th with unit directors and regional delegates.
Briefly, we must reduce our working load, adapt our working methods, and stop of all non-essential research activities. Many of our scientific collaborators work remotely to take care of themselves and their loved ones. We must acknowledge our volunteers who continue to take care of the precious mouse and rat models that we are hosting.
In this exceptional situation, the quality of service is not sufficient for the successful completion of our ongoing projects. This force majeure case obliges us to interrupt all ongoing projects and offer you to postpone them as best as possible. Established KO/KI mouse lines will be kept and delivered when we can start again the operation. We remind you that any model made in our centre has been cryopreserved and would be made available again if needed. We are aware of the consequences on your activities and we call on everyone to show solidarity and compassion to overcome this health crisis.
Our team, project managers and scientific leaders are available to exchange by email if necessary. For further inquiries, please send an email to firstname.lastname@example.org.
We would like to let you know that the entire PHENOMIN team is mobilized and we will continue to inform you if the situation changes.
We hope you remain safe, and it is important above all to take good care of yourself and your loved ones by strictly adhering to the instructions issued by the health authorities.
Cécile Frémond, Bernard Malissen and Yann Hérault
Every year, thousands of events are organised around the world during the month of February to mark the occasion of Rare Disease Day. Patient organisations, healthcare professionals, researchers, policymakers and other members of the rare disease community organise Rare Disease Day events.
This year, in Strasbourg, the Rare Disease Foundation is hosting a regional scientific conference "Research in Rare Diseases" on 28 February 2020 at the Faculty of Dentistry of Strasbourg. The aim is to promote meetings and experience sharing between the research actors of the East part of the France, for some whom the scientific project has succesfully been selected as laureats by the Rare Disease Foundation.
PHENOMIN, as a partner of the Rare Disease Foundation highly supports the biomedical research in rare disease. Basically, the successful applicants obtain a facilitated access to experimented platforms to support them in rare disease research. Our infrastructure and its 12 technical platforms has launched 3 calls for projects to support laureats in the generation and phenotyping of animal models. Therefore, we are please to welcome you to join us during this event. PHENOMIN-ICS will present recent data from mouse models that have been generated to understand rare diseases. It will be a pleasure to share with you.
A large broad of leading experts are working to catalogue all the genes in the mammalian genome to improve our understanding of disease and enable the discovery of the next generation of therapies. By the recent white paper publication, The Deep genome Project, these experts are now working together to outline how mouse genetics holds a vital role in disease research and precision medicine.
Professor Steve Brown, Chair of the IMPC Steering Committee, and Professor Kent Lloyd, University of California at Davis, both senior authors on the paper, said: “This call for a deep genome project echoes many of the strategic aims of the International Mouse Phenotyping Consortium (IMPC). The IMPC is already shining a powerful light on the function of the dark genome and its role in disease. We urgently build on this programme and undertake an even deeper and more extensive analysis of the mouse genome.”
Read how the project could transform and accelerate the biomedical sciences
Mouse embryology: practical training course
This 3-days course combines lectures and practical sessions to acquire primary expertise in mouse development. It focuses on mouse
Registration before January 28, 2020
PATHBIO MOUSE IMAGING MASTER CLASS consists of one of the three intensive courses from PATHBIO consortium. The PATHBIO project brings together an ERASMUS+ Knowledge Alliance consortium from across the globe to cooperate on pooling resources and expertise in order to build the framework for a European post graduate degree in Precision pathobiology for disease models.The Mouse Imaging Master Class is open from the 21st to the 29th of September
The course is free to participants : Registration is open
The PATHBIO team wishes you all well and safe at this very difficult time.
More information at https://imaging-pathbio.sciencesconf.org
Next to cardiovascular diseases in the EU, cancer is the leading cause of death and one of the major contributors to premature deaths. In 2016, one quarter (26.0%, 13 million people) of the total number of deaths in Europe were caused by cancer.
The EC has taken a strong stand in the fight against cancer with the inception of its Europe Beating Cancer Plan and the Cancer Mission area for Horizon Europe framework beginning in 2021.
Mouse models are used in cancer research to explore the causality between cancer genes and carcinogenesis, and as models to develop and test novel therapies. Mouse models have become ideal models for precise individualized cancer therapy thanks to the advancements in CRISPR/Cas9-mediated genome editing, patient xenograft implantation and microbiota studies.
The INFRAFRONTIER Conference 2020 ‘Targeting Cancer with Animal Models’ aims to showcase such innovative animal models used in cancer research and also introduce the Cancer Mission Board to the cancer research community.
The main objectives of this conference will be to:
This training aims to provide a general framework to get scientists started using CRISPR-Cas9 for in vivo gene editing in rodents.
Acces to program and registration
CNRS formation entreprises
The Weizmann Institute of Science is proud to announce the 16th Transgenic Technology Meeting TT2020 in Israel
A diverse program will reflect recent innovations in gene editing technology and the applications of CRISPR for generating animal models. Includes lecture sessions and panel discussions covering developmental, technical, clinical and ethical aspects of animal genome engineering, as well as a workshop on Neuro-Behavioral Phenotyping.
We are proud to welcome an array of world class scientists who will be speaking at the meeting.
Due to uncertainties regarding travel and meeting attendance as a result of the coronavirus situation, opening of registration for TT2020 has been postponed. We will keep you informed via the TT2020 site.
More information at http://www.weizmann.ac.il/conferences/TT2020/venue
Acces to detailed program and registration
CNRS formation entreprises
Le colloque a pour but principal de faciliter les échanges, de promouvoir les contacts et d’aider à la dissémination des connaissances et des compétences sur la génétique de la souris. Il s’adresse à l’ensemble des personnels s’intéressant aux modèles murins : chercheurs, post-doctorants, étudiants, personnels associés aux plateformes de transgenèse ou d’imagerie et les personnels zootechniques.
Le prochain colloque du Club des Belles Souris aura lieu le Mardi 24 Novembre à Bordeaux.
Le nombre de participants au colloque sera limité à 140 personnes.
More information at http://stemcells.free.fr/?page_id=1175
Attend the French congress in animal science
Les Sciences de l’Animal de Laboratoire tous les ans les scientifiques du domaine autour de thèmes scientifiques, règlementaires, éthiques et techniques. Le 46e Colloque annuel de l'association française se déroulera du 01 au 03 décembre 2020 dans la ville de Marseille et dont le titre sera “Expérimenter c’est aussi anticiper”. En effet, cette année L'AFSTAL traitera le thème de l’anticipation en vue de la réalisation d’un projet dans son ensemble : éthique, expérimental et scientifique et dediera la première session du colloque à la place de l’animal dans les progrès de la recherche pour répondre à une attente sociétale.
PHENOMIN sera présent à cet incontournable rendez vous français en Sciences de l’Animal de Laboratoire. venez nous rejoindre et nous rencontrer !
More information at https://www.colloque-afstal.com/2020/
CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models, however, its impact on the genome still requires careful consideration. For further insight we are pleased to present the following Charles River-hosted and Labroots-hosted webinars presented by G. Pavlovic and M-C Birling from PHENOMIN-ICS
PHENOMIN-ICS works with you from concept to model creation using homologus recombination, latest CRISPR/Cas9 and RNAi technology, and either other trangenic technics to deliver the most relevant model for your application. The effective research with rodent models depends on finding the best appropriated model for your project. How can we help you? Request a quote or email us.
More information at http://www.phenomin.fr/en-us/contact/