On behalf of the International Mouse Phenotyping Consortium (IMPC) we are pleased to announce the annual IMPC-Infrafrontier Strasbourg meeting, in Strasbourg, France, from April 20-22th 2016.
The International Mouse Phenotyping Consortium is currently composed of 18 research institutions and 6 national funders. It aims to develop a plan to harness the major world-wide mouse research programmes and infrastructures in a strategic and coordinated effort to undertake a broad-based, systematic genome-wide phenotyping project of knockout mice in order to provide the wider research community with a long-lasting resource of mammalian gene function encyclopaedia (see www.mousephenotype.org).The IMPC is generating over 20.000 knockout lines which are available to researchers through established repositories (EMMA - INFRAFRONTIER), and phenotypes are uploaded to a central database where they can be accessed and searched through by the biological and biomedical science communities. Clinicians can use IMPC data to find relevant mouse models to human disease by orthologous gene and by shared phenotypic features.
The Meeting is hosted by the French National Infrastructure in Mouse Phenogenomics PHENOMIN-ICS, a technological platform of the” institut de génétique et de biologie moléculaire et cellulaire” (IGBMC). The IGBMC was created in 1994 by Pierre Chambon and is now one of the main European research centers in biomedical research. In France, it is one of the largest research unit, involving INSERM, CNRS and the University of Strasbourg with 53 research teams. The Institute aims to develop interdisciplinary research at the interface of biology, biochemistry, physics and medicine. IGBMC has a long history in mouse research notably by creating the platform Institut Clinique de la Souris in 2002, becoming now PHENOMIN, a unique French Centre for Phenogenomics.
All the session will includes Keynote lectures.
We expect over 100 IMPC members and funders and 100 researchers of regional, national, European and international prominence (limited number of participants). We hope you'll participate in this outstanding meeting and join us in one of the main European biomedical research center in Strasbourg!
Strasbourg, capital of Europe, with its monumental cathedral featuring carvings as delicate as any piece of lacework, is definitely well worth a visit, to discover its history, its cuisine and its unique atmosphere.Thanks to the richness and sheer density of its heritage sites, the entire town center has been listed as UNESCO World Heritage.
We look forward to your on line registration.
Join us in Strasbourg!
Please download the detailed scientific programme as pdf file.
This programme also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.
1, rue Laurent Fries- Parc d’innovation
67400 ILLKIRCH- France
Entrance by the IGBMC main Building
Tel: +33 (0)188.8.131.52.00
Feel free to contact us for any Information or assistance you may need:
Shuttle buses run between Baden or Basel airports and Strasbourg every 2 or 4 hours (alsace-navette.com).
From the Strasbourg railway station, take the tramway line A in the direction "Illkirch-Lixenbuhl", exit at "Campus d'Illkirch".
The INFRAFRONTIER Research Infrastructure provides access to mouse models, data and scientific platforms and services to study the functional role of the genome in human health and disease, using the mouse as a model. It addresses the full range from common disease such diabetes or age-related cancers to rare diseases.
The INFRAFRONTIER Research Infrastructure can be accessed bottom-up by individual scientists and research groups in academia and industry. It also provides top-down capacities for large scale global initiatives such as the International Mouse Phenotyping Consortium (IMPC).
Archiving and distribution of scientifically valuable mouse strains is provided by the European Mouse Mutant Archive (EMMA), one of the world leading mouse repositories. EMMA is a widely recognized and used resource in the research community, due to its high quality standards and standardized operation procedures.
The INFRAFRONTIER Mouse Clinics provide access to whole organism, systemic analysis of genotype–phenotype interactions using cutting–edge analytical and diagnostic methodology, based on common quality standards and operation procedures.
The International Mouse Phenotyping Consortium is currently composed of 18 research institutions and 5 national funders and is expected to increase membership as the programme moves forward.
The Consortium's goal is to develop a plan to harness the major world-wide mouse research programmes and infrastructures in a strategic and coordinated effort to undertake a broad-based, systematic genome-wide phenotyping project of knockout mice in order to provide the wider research community with a long-lasting resource of mammalian gene function information.
The scientific community has taken advantage of its fundamental similarity to humans at the genetic level (>95% at the gene level), similar physiology and anatomy, its relative low cost compared to other mammals, and nearly 100 years of genetic study.
There is an extensive toolkit for the manipulation of the mouse genome and the generation of new disease models. After completing the mouse genome sequence, an international consortium was developed, the International Knock-out Mouse Consortium (IKMC) to systematically generate mutant ES cells for every gene in the mouse genome (20,000 plus genes).
The IMPC builds on the efforts of IKMC to produce knockout mice and carry out high-throughput phenotyping of each line in order to determine the function of every gene in the mouse genome. These mice are preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.
The approaches that are being developed build on the efforts of a number of pilot programme around the world such as the EUMODIC programme and the MGP programme. From 2011/12 onwards the IMPC will continue the task to generate knockout mice and phenotype the remainder of the 20,000 plus genes in a worldwide coordinated programme.
Building the First Comprehensive Catalogue of a Mamalian Genome
The knockout mouse is a powerfull tool for precision medicine. The biological changes associated with gene activation provides important clues to mammalian gene function. By creating and broadly phenotyping a knock out mouse strain for every gene. The IMPC is building the first truly comprehensive, functional catalogue of a mammalian genome. This large scale endeavour requires unprecedent cooperation among leading international mouse research centers. As the first IMPC phenotype data becomes available, IMPC partners are transforming our understanding of the mammalian genome.
The IMPC is generating over 20.000 mutant mouse strains from IKMC resources and making them publicly available through established repositories. Each strain carries a flexible allele design where genes can be inactivated only in tissues of interest. With all strains on a uniform genetic background, alleles can be ‘mixed and matched’ to study complex genetic interactions. Working together, IMPC partners allow researchers to focus on innovative work rather than use their own resources generating mutant mouse strains.
For clinical researchers who are looking for connections between gene and disease, IMPC is a gene phenotyping discovery resource that provides an unprecedent volume of high quality data. Clinicians can use IMPC data to find relevant mouse models to human disease by orthologous gene and by shared phenotypic features.
Big Phenotype Data
IMPC centers are collecting phenotype data on over 250 parameters in an unbiased manner. Data is freely available for all genes from the well-studied and to the poorly characterized. Biomedical researchers can explore IMPC findings by an intuitive online portal while bioinformaticians will find highly standardized data that is interchangable with other data types.