External users will have access to the PHENOMIN services based on the scientific evaluation of their project by an external evaluation committee that will evaluate and prioritize the projects according to the following criteria: the PHENOMIN resources mobilized by the project, the potential to distribute the model under consideration and the possibility to make the resulting data publicly available, the innovative nature of the project, and the scientific interest. National users will request services from PHENOMIN based on an internet common platform. Each project will be evaluated using the criteria described above and in case of a positive selection the cost for the project will be given to the user for placing an official order.
6th Call: CreERT2
We are glad to announce the new PHENOMIN call dedicated to generation and characterization of CreERT2 cell specific promoter driven deleter mouse lines.
Since 2011, PHENOMIN has generated more than 150 models with conditional potential. In the frame of the International Mouse Phenotyping Consortium (IMPC) more than 5,000 genes are already committed to the IMPC pipeline. Most of these models can be driven in conditional alleles.
We aim to maximize the utility of this resource by offering the scientific community with the possibility to nominate the making of new Cre or CreERT2 lines.
5th Call: IMPC
Since 2011, PHENOMIN has generated more than 150 models. In the frame of the International Mouse Phenotyping Consortium (IMPC) more than 5,000 genes are already committed to the IMPC pipeline.
In the frame of this 5th call, we have added constitutive knock-out models to be generated using CRISPR (clustered regularly interspaced short palindromic repeats) genome editing technology.
4th Call: Fondation Maladies Rares
The "Fondation Maladies Rares" and the National Infrastructure PHENOMIN which includes the Institut Clinique de la Souris (ICS, Illkirch), the Centre for Immunophenomics (CIPHE, Marseille) and the Transgenesis and Archiving of Animal Models (TAAM, Orléans, Villejuif) are pleased to launch their 2nd joint call for the creation and exploration of mouse models for rare diseases.
3rd Call: IMPC
Today, through its partnership with the International Mouse Phenotyping Consortium (IMPC) PHENOMIN has generated nearly 150 models and more than 5.000 genes are already committed to the pipeline of the IMPC.
2nd Call: Fondation Maladies Rares
The "Fondation Maladies Rares" and the National Infrastructure PHENOMIN (ICS, TAAM, CIPHE) are pleased to announce the launch the call for joint research projects: "Murine models and rare diseases".
1st Call: IMPC
Through its partnership in the IMPC, PHENOMIN will, over the next 5 years, produce over 235 transgenic mouse lines bearing a single gene knock-out and analyse them using broad-based, high-throughput phenotyping. These knockout mice, together with the wealth of associated data, will serve as a valuable, freely available, resource for French researchers investigating gene function and human pathophysiology.