Centre for ImmunoPHEnomics (CIPHE)

The Centre for ImmunoPHEnomics (CIPHE, Inserm US12 and CNRS/Aix-Marseille Université UMS3367) is a new state-of-the-art facility dedicated to create innovative customized mouse models delivered under a specified and opportunistic pathogen free status (SOPF) and to analyze in a comprehensive and standardized manner the immune system of the mouse under normal and infectious conditions.
CIPHE, with its cutting-edge expertise in mouse genetics and immunology also pursues the development of knock-in and knock-out mouse models permitting to understand the nature of the "molecular machines" that determine the function of the cells that constitute the immune system. CIPHE comprises a knock-in/knock-out booster, a microinjection and cryopreservation unit, an immunophenotyping unit, a BSL3 facility capable of in vivo non-invasive imaging of infectious processes, and a SPF animal house. Using multiparametric flow and mass cytometry as well as advanced microscopy approaches, CIPHE has the unique ability to decipher at the systemic level the complexity of the immune system based on the evaluation of up to 300 quantitative parameters.

Mouse Clinical Institute (ICS)

The ICS is a large-scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.
It has also established several resources of genetic tools such as CRE-ERT2 lines, nuclear receptor conditional mutants and a list of GEM lines generated through different european consortia.

Transgenesis, Archiving and Animal Models (TAAM)

The TAAM is a CNRS laboratory providing the scientific community with fundamental biomedical and pharmaceutical research. It offers a collection of services related to the provision of murine models found in 3 departments each specialized in a specific field of competence:

  • The SEAT (SErvice for Transgenic Animal) can generate customized transgenic murine models by conventional transgenesis or targeted transgenesis with the production of modified ES cells. This laboratory also offers the possibility of developing transgenic strains from on-site generated founders.
  • The CDTA (Department for Cryopreservation, Distribution, Typing & Archiving) is a center for breeding and distributing transgenic and mutant mice in different states of health sanitary status conditions (SPF, SOPF, axenic, gnotoxenic). Breeding capacity of the CDTA is organized in 7 facilities with different types of housing: open cages in protected area to develop strains, ventilated racks in protected area to maintain and preserve strains, isolators to protect susceptible, axenic or gnotoxenic strains, open or ventilated cages in experimentation zone.
  • The CIPA (the Centre for Imaging Animal) provides researchers with innovative 2D and 3D imaging, allowing non-invasive exploration techniques to be developed in murine models. Because of its close co-operation with high-tech industries, the CIPA is able of implementing the most recent technologies. It can propose 2D imaging as X-ray Radiology, Scintigraphy or Optical imaging but also 3D imaging as CT Scanner, 3D scintigraphy, Optical Imaging or Positron Emission Tomography.