Current call

PHENOMIN 7th call for proposal

July 2017 : Publication of results

The "Fondation Maladies Rares" in partnership with the National Infrastructure PHENOMIN, is supporting 12 research projects focusing on the development and the study of mouse models in the field of rare diseases.

The Joint Call "Mouse models and rare diseases" aims to give a significant impetus to the creation and the study of mouse models for rare diseases in order to elucidate underlying pathophysiological mechanisms and to develop new therapeutic approaches. This joint call is dedicated to the creation and the characterization of mouse models for rare diseases - constitutive Knock-Out (KO) / conditional Knock-Out (cKO), Knock-In (KI) and transgenic mice.

Icon List of projects 2017 (87.4 KB)  

Congratulations !

More than 50 mouse rare disease models are now available for your research.

*******************************************************************************************

The French Foundation for rare diseases (Fondation maladies rares) and the French National Infrastructure PHENOMIN are pleased to launch their 3rd joint call for the creation and exploration of mouse models for rare diseases.
The call for projects 'Mouse models and rare diseases' aims to give a significant boost to the development of mouse models, in order to:

  • gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified;
  • test and validate therapeutic proofs of concept, at the pre-clinical in vivo level.

Indeed, producing these models meets a key objective in the development of a therapeutic strategy. After their initial in vitro testing, therapeutic proofs of concept must be tested in a living model that recapitulates as closely as possible both the phenotype and biological defects associated to the human disease. Such a model should provide appropriate data regarding the safety and the efficiency of the drug, thus evaluating its benefit/risk ratio, prior to conducting early phases of a therapeutic trial. PHENOMIN and the French Foundation for rare diseases combine their efforts in order to achieve these objectives through the joint call for proposals for the generation and characterization of mouse models, dedicated to rare diseases. This action is part of the objectives of PHENOMIN to develop mouse model resources that will be made available to the scientific community.
 
Upload the call for proposal Icon 2016-MousemodelsRareDiseases-final.pdf (732.9 KB)

Submission deadline for proposals: February 9, 2017, 5:00 pm
 
On line submission: HERE.